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Query: PIK3R1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PIK3R1 0 -0.294 1.910 -1.220 -0.441 0.147

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for PIK3R1:


Pubmed-PIK3R1 »
Uniprot-PIK3R1 »
Biogrid-PIK3R1 »
ProteomicsDB-PIK3R1 »

Tumorportal-PIK3R1 »
COSMIC-PIK3R1 »
GenomeRNAi-PIK3R1 »
Genecards-PIK3R1


Protein-protein Interactions for PIK3R1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PIK3R1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DEFA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FLRT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAVCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL20RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NLGN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIK3R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIK3R3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF19B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGFBR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PIK3R1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members SH3_2 IPR011511 0.08
Category members SH2 IPR000980 0.05
Category members RhoGAP_dom IPR000198 0
Category members SH3_domain IPR001452 0
Category members PI3kinase_P85 IPR001720 0
Category members Guanylate-bd_C IPR003191 0


Protein complexes (CORUM database) featuring PIK3R1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2551 PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated Database 0.05
Category members Corum 2577 Sam68-p85 P13K-IRS-1-IR signaling complex Database 0.04
Category members Corum 2529 LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated Database 0.01
Category members Corum 2470 p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex Database 0
Category members Corum 2480 CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) Database 0
Category members Corum 2574 CD19-Vav-PI 3-kinase (p85 subunit) complex Database 0
Category members Corum 2922 LAT-PLC-gamma-1-p85-GRB2-SOS signaling complex, C305 activated Database 0
Category members Corum 2944 Notch1-p56lck-PI3K complex Database 0
Category members Corum 3133 Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) Database 0


Categories featuring PIK3R1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members Pathway Pathway_636 PID_PI3K_PLC_TRK_PATHWAY 0 1.85
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_611 PID_ECADHERIN_KERATINOCYTE_PATHWAY 0 1.34
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members Pathway Pathway_549 REACTOME_GAB1_SIGNALOSOME 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members Pathway Pathway_559 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS 0 1.1
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_608 SIG_CD40PATHWAYMAP 0 0.89
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_583 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR 0 0.68
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_651 BIOCARTA_RAS_PATHWAY 0 0.61
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members Pathway Pathway_628 BIOCARTA_GSK3_PATHWAY 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members GO Category GO:0034644 cellular response to UV Database 0.49
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_542 BIOCARTA_AKT_PATHWAY 0 0.45
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_592 REACTOME_SIGNALING_BY_FGFR1_MUTANTS 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members Pathway Pathway_590 REACTOME_PI_3K_CASCADE 0 0.37
Category members Pathway Pathway_528 REACTOME_SIGNALING_BY_FGFR_MUTANTS 0 0.37
Category members Pathway Pathway_607 REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members Pathway Pathway_604 REACTOME_PI3K_AKT_ACTIVATION 0 0.32
Category members Pathway Pathway_614 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0046854 phosphatidylinositol phosphorylation Database 0.31
Category members Pathway Pathway_548 BIOCARTA_RAC1_PATHWAY 0 0.3
Category members Pathway Pathway_562 PID_NCADHERIN_PATHWAY 0 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_510 SIG_CHEMOTAXIS 0 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members Pathway Pathway_536 BIOCARTA_ECM_PATHWAY 0 0.25
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_581 PID_NECTIN_PATHWAY 0 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members Pathway Pathway_428 PID_THROMBIN_PAR1_PATHWAY 0 0.18
Category members Pathway Pathway_566 BIOCARTA_HCMV_PATHWAY 0 0.18
Category members Pathway Pathway_615 BIOCARTA_CDC42RAC_PATHWAY 0 0.18
Category members Pathway Pathway_534 BIOCARTA_GLEEVEC_PATHWAY 0 0.18
Category members Pathway Pathway_596 PID_TRAIL_PATHWAY 0 0.17
Category members Pathway Pathway_427 PID_IL23_PATHWAY 0 0.17
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_629 PID_EPHB_FWD_PATHWAY 0 0.14
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members Pathway Pathway_532 PID_ERBB2_ERBB3_PATHWAY 0 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members Pathway Pathway_622 REACTOME_CD28_CO_STIMULATION 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_450 BIOCARTA_LONGEVITY_PATHWAY 0 0.13
Category members Pathway Pathway_347 BIOCARTA_ARF_PATHWAY 0 0.12
Category members Pathway Pathway_525 BIOCARTA_CXCR4_PATHWAY 0 0.11
Category members Pathway Pathway_537 PID_IFNG_PATHWAY 0 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members Pathway Pathway_578 BIOCARTA_EGF_PATHWAY 0 0.09
Category members Pathway Pathway_584 BIOCARTA_TPO_PATHWAY 0 0.08
Category members Pathway Pathway_503 REACTOME_IL_RECEPTOR_SHC_SIGNALING 0 0.08
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_513 ST_ADRENERGIC 0 0.08
Category members Pathway Pathway_647 BIOCARTA_NKCELLS_PATHWAY 0 0.06
Category members GO Category GO:0006661 phosphatidylinositol biosynthetic process Database 0.06
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_511 PID_EPHA2_FWD_PATHWAY 0 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members GO Category GO:0043559 insulin binding Database 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0048009 insulin-like growth factor receptor signaling pathway Database 0.04
Category members Pathway Pathway_103 REACTOME_PI_METABOLISM 0 0.04
Category members Pathway Pathway_486 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 0 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members Pathway Pathway_654 PID_IL5_PATHWAY 0 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members Pathway Pathway_630 BIOCARTA_PDGF_PATHWAY 0 0.03
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members GO Category GO:0043560 insulin receptor substrate binding Database 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_617 BIOCARTA_TFF_PATHWAY 0 0.02
Category members Pathway Pathway_642 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE 0 0.02
Category members Pathway Pathway_639 BIOCARTA_HER2_PATHWAY 0 0.01
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_102 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE 0 0
Category members Pathway Pathway_1177 REACTOME_IL_7_SIGNALING 0 0
Category members Pathway Pathway_176 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_212 BIOCARTA_IGF1R_PATHWAY 0 0
Category members Pathway Pathway_216 BIOCARTA_EDG1_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_249 BIOCARTA_CREB_PATHWAY 0 0
Category members Pathway Pathway_250 BIOCARTA_BAD_PATHWAY 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_419 PID_IL4_2PATHWAY 0 0
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_436 KEGG_VEGF_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_439 BIOCARTA_GCR_PATHWAY 0 0
Category members Pathway Pathway_445 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_502 PID_PI3KCI_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_506 REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 0 0
Category members Pathway Pathway_512 REACTOME_IL_2_SIGNALING 0 0
Category members Pathway Pathway_515 ST_B_CELL_ANTIGEN_RECEPTOR 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_531 PID_PDGFRA_PATHWAY 0 0
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members Pathway Pathway_539 PID_LYMPH_ANGIOGENESIS_PATHWAY 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Pathway Pathway_544 BIOCARTA_BCELLSURVIVAL_PATHWAY 0 0
Category members Pathway Pathway_547 PID_EPHRINB_REV_PATHWAY 0 0
Category members Pathway Pathway_550 PID_IL3_PATHWAY 0 0
Category members Pathway Pathway_551 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING 0 0
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_553 BIOCARTA_PTEN_PATHWAY 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_556 BIOCARTA_TRKA_PATHWAY 0 0
Category members Pathway Pathway_564 PID_AVB3_OPN_PATHWAY 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members Pathway Pathway_569 PID_GMCSF_PATHWAY 0 0
Category members Pathway Pathway_570 BIOCARTA_ERK5_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_574 BIOCARTA_HDAC_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_576 REACTOME_REGULATION_OF_SIGNALING_BY_CBL 0 0
Category members Pathway Pathway_577 BIOCARTA_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_582 BIOCARTA_IL7_PATHWAY 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0
Category members Pathway Pathway_586 REACTOME_TIE2_SIGNALING 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_591 BIOCARTA_IL2RB_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_594 PID_HEDGEHOG_2PATHWAY 0 0
Category members Pathway Pathway_597 BIOCARTA_FCER1_PATHWAY 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_609 PID_ERBB4_PATHWAY 0 0
Category members Pathway Pathway_610 PID_NFKAPPAB_ATYPICAL_PATHWAY 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_613 BIOCARTA_ACH_PATHWAY 0 0
Category members Pathway Pathway_616 BIOCARTA_GH_PATHWAY 0 0
Category members Pathway Pathway_618 REACTOME_DOWNSTREAM_TCR_SIGNALING 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members Pathway Pathway_624 PID_AR_NONGENOMIC_PATHWAY 0 0
Category members Pathway Pathway_627 BIOCARTA_NGF_PATHWAY 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_632 BIOCARTA_IGF1_PATHWAY 0 0
Category members Pathway Pathway_633 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 0 0
Category members Pathway Pathway_635 BIOCARTA_CTLA4_PATHWAY 0 0
Category members Pathway Pathway_637 BIOCARTA_CTCF_PATHWAY 0 0
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members Pathway Pathway_640 PID_NETRIN_PATHWAY 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_643 PID_RET_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members Pathway Pathway_655 PID_CXCR3_PATHWAY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_659 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS 0 0
Category members Pathway Pathway_703 PID_EPO_PATHWAY 0 0
Category members Pathway Pathway_97 KEGG_TYPE_II_DIABETES_MELLITUS 0 0
Category members Disease phenotype Autosomal_agammaglobulinemia Autosomal agammaglobulinemia Database 0
Category members GO Category GO:0001953 negative regulation of cell-matrix adhesion Database 0
Category members GO Category GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity Database 0
Category members GO Category GO:0005158 insulin receptor binding Database 0
Category members GO Category GO:0005159 insulin-like growth factor receptor binding Database 0
Category members GO Category GO:0005168 neurotrophin TRKA receptor binding Database 0
Category members GO Category GO:0005545 1-phosphatidylinositol binding Database 0
Category members GO Category GO:0005942 phosphatidylinositol 3-kinase complex Database 0
Category members GO Category GO:0005943 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0014065 phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0031295 T cell costimulation Database 0
Category members GO Category GO:0032760 positive regulation of tumor necrosis factor production Database 0
Category members GO Category GO:0035014 phosphatidylinositol 3-kinase regulator activity Database 0
Category members GO Category GO:0043125 ErbB-3 class receptor binding Database 0
Category members GO Category GO:0043548 phosphatidylinositol 3-kinase binding Database 0
Category members GO Category GO:0043551 regulation of phosphatidylinositol 3-kinase activity Database 0
Category members GO Category GO:0045671 negative regulation of osteoclast differentiation Database 0
Category members GO Category GO:0046326 positive regulation of glucose import Database 0
Category members GO Category GO:0060396 growth hormone receptor signaling pathway Database 0


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