Results for the Category
insulin receptor substrate binding
(GO:0043560)
| RNAi screen result | RNAPII IP (MG132) | CSB IP | CSB IP (MG132) | Chrom. | Chrom. (MG132) | Ubi /Phospo | Ubi /Phospho (MG132) |
| W | |||||||
| Gene name | MGoogle Score | RNAi high | RNAi low | RNAPII-IP (MG132) | CSB-IP | CSB-IP (MG132) | Chrom. | Chrom. (MG132) |
|---|---|---|---|---|---|---|---|---|
| INSR | 2 | -0.850 | 0.830 | 1.143 | 0.785 | |||
| IGF1R | 1 | -0.490 | 0.750 | 1.476 | 0.714 | |||
| PIK3CB | 0 | -1.390 | 2.350 | |||||
| PIK3CB | 0 | -0.710 | 1.450 | |||||
| PRKCZ | 0 | -0.290 | 0.310 | |||||
| PIK3CA | 0 | |||||||
| PIK3R1 | 0 | 1.910 | -1.220 | -0.441 | 0.147 | |||
| PRKCD | 0 | 0.250 | 0.070 | 0.578 | 0.427 | |||
| GRB2 | 0 | -0.240 | 0.300 | -1.021 | 0.057 | 0.906 | ||
| WDR6 | 0 | 0.590 | -0.760 | -0.847 | -0.197 | -0.347 | ||
| PTPN11 | 0 | -0.210 | -0.400 | 0.644 | 1.053 | 0.451 |
| Gene name | PTM type | PTM site | UV | UV (MG132) | Sequence |
|---|---|---|---|---|---|
| GRB2 | Ubiquitylation | K10 | 0.146 | _YDFK(gl)ATADDELSFK_ | |
| GRB2 | Ubiquitylation | K20 | -0.078 | _ATADDELSFK(gl)R_ | |
| GRB2 | Ubiquitylation | K69 | -0.362 | 0.641 | _AK(gl)AEEMLSK_ |
| GRB2 | Ubiquitylation | K76 | 0.754 | _AEEMLSK(gl)QR_ | |
| GRB2 | Ubiquitylation | K109 | 0.381 | -0.002 | _FGNDVQHFK(gl)VLR_ |
| IGF1R | Ubiquitylation | K47 | 1.146 | _NDYQQLK(gl)R_ | |
| IGF1R | Ubiquitylation | K1033 | 5.779 | _VAIK(gl)TVNEAASMR_ | |
| IGF1R | Ubiquitylation | K1168 | 0.191 | _K(gl)GGKGLLPVR_ | |
| IGF1R | Ubiquitylation | K1171 | 0.232 | _GGK(gl)GLLPVR_ | |
| INSR | Ubiquitylation | K1022 | -0.603 | _EK(gl)ITLLR_ | |
| INSR | Ubiquitylation | K1047 | 0.305 | 0.711 | _DIIK(gl)GEAETR_ |
| INSR | Ubiquitylation | K1057 | 0.482 | 0.484 | _VAVK(gl)TVNESASLR_ |
| INSR | Ubiquitylation | K1352 | 1.606 | 2.754 | _DGGSSLGFK(gl)R_ |
| PIK3CA | Ubiquitylation | K864 | 0.390 | 0.588 | _NSHTIM(ox)QIQCK(gl)GGLK_ |
| PIK3CA | Ubiquitylation | K868 | 0.204 | 0.651 | _NSHTIM(ox)QIQCKGGLK(gl)_ |
| PIK3CA | Ubiquitylation | K974 | -0.273 | _GAQECTK(gl)TREFER_ | |
| PIK3CB | Ubiquitylation | K1044 | 0.990 | _SEEEALKQFKQK(gl)_ | |
| PRKCD | Ubiquitylation | K138 | -0.141 | _SEDEAK(gl)FPTMNR_ | |
| PRKCD | Ubiquitylation | K222 | 0.185 | 0.658 | _DTIFQK(gl)ER_ |
| PRKCD | Phosphorylation | S302 | -0.240 | -0.222 | _S(ph)DSASSEPVGIYQGFEK_ |
| PRKCD | Phosphorylation | S304 | 0.378 | 0.289 | _RSDS(ph)ASSEPVGIYQGFEK_ |
| PRKCD | Phosphorylation | S506 | -0.213 | 0.200 | _AS(ph)TFCGTPDYIAPEILQGLK_ |
| PRKCD | Phosphorylation | T507 | -0.149 | 0.240 | _AS(ph)TFCGTPDYIAPEILQGLK_ |
| PRKCD | Ubiquitylation | K641 | -2.000 | _DYSNFDQEFLNEK(gl)AR_ | |
| PRKCD | Phosphorylation | S645 | 0.577 | 0.832 | _ARLS(ph)YSDK_ |
| PRKCD | Phosphorylation | S647 | 0.886 | 0.853 | _ARLSYS(ph)DK_ |
| PRKCZ | Phosphorylation | T560 | -0.884 | -1.578 | _KQALPPFQPQITDDYGLDNFDTQFTSEPVQLT(ph)PDDEDAIKR_ |
| PTPN11 | Ubiquitylation | K124 | 0.562 | _EAEK(gl)LLTEK_ | |
| WDR6 | Ubiquitylation | K343 | 0.683 | _GLGVSALCFK(gl)SR_ | |
| WDR6 | Phosphorylation | S545 | 0.380 | _AGAGAPVVGS(ph)GSSGGGNAFTGLGPVSTLPSLHGK_ | |
| WDR6 | Ubiquitylation | K708 | -0.627 | -0.069 | _EITCVK(gl)R_ |
| WDR6 | Ubiquitylation | K855 | 0.268 | -0.051 | _MVK(gl)VDPETR_ |
| WDR6 | Ubiquitylation | K910 | -0.462 | _ILQLLAETFHHK(gl)R_ |
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