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Query: PTPN11

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PTPN11 0 2.710 -0.210 -0.400 0.644 1.053 0.451

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PTPN11 Ubiquitylation K124 0.562 _EAEK(gl)LLTEK_

Background Information for PTPN11:


Pubmed-PTPN11 »
Uniprot-PTPN11 »
Biogrid-PTPN11 »
ProteomicsDB-PTPN11 »

Tumorportal-PTPN11 »
COSMIC-PTPN11 »
GenomeRNAi-PTPN11 »
Genecards-PTPN11


Protein-protein Interactions for PTPN11
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCGR2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPX7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPZL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NOSIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OVCA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIGLEC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCEAL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THEMIS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM220 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PTPN11
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH2 IPR000980 0.05
Category members Tyr_Pase_rcpt/non-rcpt IPR000242 0
Category members Tyr/Dual-sp_Pase IPR000387 0
Category members Tyr_Pase_cat IPR003595 0
Category members Tyr_Pase_non-rcpt_typ-6/11 IPR012152 0
Category members Prot-tyrosine_phosphatase-like IPR029021 0


Protein complexes (CORUM database) featuring PTPN11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3186 GRB2-SHP-2 complex, PDGF stimulated Database 0.09
Category members Corum 2551 PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated Database 0.05
Category members Corum 3183 PDGFRA-SHP-2 complex, PDGF stimulated Database 0
Category members Corum 5564 LMO4-gp130 complex Database 0


Categories featuring PTPN11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0000077 DNA damage checkpoint Database 2.04
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0040014 regulation of multicellular organism growth Database 0.35
Category members Pathway Pathway_562 PID_NCADHERIN_PATHWAY 0 0.29
Category members Disease phenotype LEOPARD_SYNDROME LEOPARD SYNDROME Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members Disease phenotype NOONAN_SYNDROME NOONAN SYNDROME Database 0.19
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_532 PID_ERBB2_ERBB3_PATHWAY 0 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_537 PID_IFNG_PATHWAY 0 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members GO Category GO:0046825 regulation of protein export from nucleus Database 0.11
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members Disease phenotype Juvenile_myelomonocytic_leukemia Juvenile myelomonocytic leukemia Database 0.08
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members GO Category GO:0060334 regulation of interferon-gamma-mediated signaling pathway Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members Pathway Pathway_654 PID_IL5_PATHWAY 0 0.04
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members GO Category GO:0043560 insulin receptor substrate binding Database 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members GO Category GO:0048609 multicellular organismal reproductive process Database 0.03
Category members Pathway Pathway_1079 BIOCARTA_IL6_PATHWAY 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_445 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members Pathway Pathway_550 PID_IL3_PATHWAY 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members Pathway Pathway_569 PID_GMCSF_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_577 BIOCARTA_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0
Category members Pathway Pathway_632 BIOCARTA_IGF1_PATHWAY 0 0
Category members Pathway Pathway_635 BIOCARTA_CTLA4_PATHWAY 0 0
Category members Pathway Pathway_643 PID_RET_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_703 PID_EPO_PATHWAY 0 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0004725 protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0004726 non-membrane spanning protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0005070 SH3/SH2 adaptor activity Database 0
Category members GO Category GO:0005158 insulin receptor binding Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0006641 triglyceride metabolic process Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0009755 hormone-mediated signaling pathway Database 0
Category members GO Category GO:0009967 positive regulation of signal transduction Database 0
Category members GO Category GO:0016311 dephosphorylation Database 0
Category members GO Category GO:0016791 phosphatase activity Database 0
Category members GO Category GO:0030971 receptor tyrosine kinase binding Database 0
Category members GO Category GO:0031295 T cell costimulation Database 0
Category members GO Category GO:0031748 D1 dopamine receptor binding Database 0
Category members GO Category GO:0033628 regulation of cell adhesion mediated by integrin Database 0
Category members GO Category GO:0035265 organ growth Database 0
Category members GO Category GO:0035335 peptidyl-tyrosine dephosphorylation Database 0
Category members GO Category GO:0036302 atrioventricular canal development Database 0
Category members GO Category GO:0038127 ERBB signaling pathway Database 0
Category members GO Category GO:0042445 hormone metabolic process Database 0
Category members GO Category GO:0043274 phospholipase binding Database 0
Category members GO Category GO:0046676 negative regulation of insulin secretion Database 0
Category members GO Category GO:0046887 positive regulation of hormone secretion Database 0
Category members GO Category GO:0046888 negative regulation of hormone secretion Database 0
Category members GO Category GO:0048013 ephrin receptor signaling pathway Database 0
Category members GO Category GO:0048806 genitalia development Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0051428 peptide hormone receptor binding Database 0
Category members GO Category GO:0060325 face morphogenesis Database 0
Category members GO Category GO:0060333 interferon-gamma-mediated signaling pathway Database 0
Category members GO Category GO:0060337 type I interferon signaling pathway Database 0
Category members GO Category GO:0060338 regulation of type I interferon-mediated signaling pathway Database 0


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