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PID_IL6_7_PATHWAY
(Pathway_652)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
JUN 3 -0.930 0.930 -0.126
MAPK14 2 -0.160 -0.350
HSP90B1 2 0.100 0.120 0.724 1.982 -1.206 0.484 0.477
PIAS1 0 -1.020 1.720 -1.034 -0.678 0.471 -0.051 1.019
MAP2K4 0 -0.300 0.320
TIMP1 0 0.660 -0.830
MAP2K6 0 1.270 -0.780
GAB1 0 1.950 -1.110
STAT1 0 -0.550 0.170
SOS1 0 0.500 -0.620 -0.570
PIK3CA 0
RAC1 0 -0.580 1.580 0.486 -0.364 -0.568
MYC 0 0.170 0.550 -2.443 -0.949 -0.454 -1.290
AKT1 0 -0.050 0.700
AKT1 0 0.860 -0.040
MCL1 0 1.740 -0.780 -0.419
PIK3R1 0 1.910 -1.220 -0.441 0.147
JAK1 0 0.190 -0.100 -1.504 -0.381 -0.438
PRKCD 0 0.250 0.070 0.578 0.427
STAT3 0 0.200 -1.270 0.334
JUNB 0 0.350 -0.410
BCL2L1 0
CEBPB 0 0.400 -0.930
GRB2 0 -0.240 0.300 -1.021 0.057 0.906
PTPN11 0 -0.210 -0.400 0.644 1.053 0.451

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AKT1 Phosphorylation S124 0.252 0.311 _SGS(ph)PSDNSGAEEMEVSLAKPK_
AKT1 Phosphorylation S126 -0.241 _SGSPS(ph)DNSGAEEM(ox)EVSLAK_
AKT1 Ubiquitylation K301 0.988 _EGIK(gl)DGATMK_
BCL2L1 Ubiquitylation K87 0.026 _EVIPMAAVK(gl)QALR_
CEBPB Phosphorylation S231 -0.660 _AYLGYQAVPSGSSGSLSTSSSSS(ph)PPGTPSPADAK_
GAB1 Phosphorylation S266 0.756 0.551 _SYS(ph)HDVLPK_
GAB1 Phosphorylation S367 0.230 0.176 _TAS(ph)DTDSSYCIPTAGMS(ph)PSR_
GAB1 Phosphorylation T369 -0.352 _TASDT(ph)DSSYCIPTAGMS(ph)PSR_
GAB1 Phosphorylation S381 -0.481 0.139 _TASDTDSSYCIPTAGM(ox)S(ph)PSR_
GAB1 Phosphorylation S401 0.266 0.788 _DAS(ph)SQDCYDIPR_
GAB1 Phosphorylation S402 0.328 0.633 _DASS(ph)QDCYDIPR_
GAB1 Phosphorylation S419 0.540 _SSS(ph)LEGFHNHFK_
GRB2 Ubiquitylation K10 0.146 _YDFK(gl)ATADDELSFK_
GRB2 Ubiquitylation K20 -0.078 _ATADDELSFK(gl)R_
GRB2 Ubiquitylation K69 -0.362 0.641 _AK(gl)AEEMLSK_
GRB2 Ubiquitylation K76 0.754 _AEEMLSK(gl)QR_
GRB2 Ubiquitylation K109 0.381 -0.002 _FGNDVQHFK(gl)VLR_
HSP90B1 Ubiquitylation K95 0.097 1.380 _LIINSLYK(gl)NK_
HSP90B1 Ubiquitylation K97 -0.155 1.541 _NK(gl)EIFLR_
HSP90B1 Ubiquitylation K161 0.157 0.544 _EELVK(gl)NLGTIAK_
HSP90B1 Ubiquitylation K168 1.363 _NLGTIAK(gl)SGTSEFLNK_
HSP90B1 Phosphorylation S306 -0.709 0.213 _TETVEEPMEEEEAAKEEKEES(ph)DDEAAVEEEEEEK_
HSP90B1 Ubiquitylation K404 -0.189 1.394 _GLFDEYGSK(gl)K_
HSP90B1 Ubiquitylation K405 -0.189 1.394 _GLFDEYGSK(gl)K_
HSP90B1 Ubiquitylation K455 0.816 0.384 _ETLQQHK(gl)LLK_
HSP90B1 Ubiquitylation K593 -0.763 0.376 _FQNVAK(gl)EGVK_
HSP90B1 Ubiquitylation K663 -0.272 _IMK(gl)AQAYQTGK_
HSP90B1 Ubiquitylation K671 -0.264 0.676 _AQAYQTGK(gl)DISTNYYASQK_
HSP90B1 Ubiquitylation K682 0.380 1.163 _DISTNYYASQK(gl)K_
HSP90B1 Ubiquitylation K683 0.380 1.163 _DISTNYYASQK(gl)K_
JAK1 Ubiquitylation K227 -0.405 _YIPETLNK(gl)SIR_
JAK1 Ubiquitylation K249 0.116 0.771 _DFLK(gl)EFNNK_
JAK1 Ubiquitylation K559 -0.478 _EISNLLVATK(gl)K_
JUN Phosphorylation S58 -0.167 -1.247 _AKNS(ph)DLLTSPDVGLLK_
JUN Phosphorylation T62 2.545 1.674 _NSDLLT(ph)SPDVGLLK_
JUN Phosphorylation S63 2.030 1.458 _NSDLLTS(ph)PDVGLLK_
JUN Ubiquitylation K70 9.213 _NSDLLTSPDVGLLK(gl)_
JUN Phosphorylation S73 1.499 0.845 _LAS(ph)PELER_
JUN Phosphorylation S243 -0.642 -1.399 _LQALKEEPQTVPEMPGETPPLS(ph)PIDMESQER_
JUN Ubiquitylation K309 1.034 0.155 _EQVAQLK(gl)QK_
JUNB Phosphorylation T255 -0.205 _DAT(ph)PPVS(ph)PINMEDQER_
JUNB Phosphorylation S259 -0.205 _DAT(ph)PPVS(ph)PINMEDQER_
MAP2K4 Phosphorylation S80 0.441 _LRTHS(ph)IESSGK_
MAP2K6 Phosphorylation T28 -1.813 -0.792 _EAFEQPQTSST(ph)PPRDLDSK_
MAP2K6 Ubiquitylation K232 0.220 _INPELNQK(gl)GYSVK_
MAPK14 Phosphorylation S2 3.221 3.623 _(ac)S(ph)QERPTFYR_
MAPK14 Phosphorylation T180 0.958 1.087 _HTDDEM(ox)T(ph)GYVATR_
MAPK14 Phosphorylation Y182 1.388 1.374 _HTDDEM(ox)TGY(ph)VATR_
MAPK14 Ubiquitylation K249 0.073 -1.380 _LVGTPGAELLKK(gl)_
MCL1 Ubiquitylation K40 -0.321 _LLATEK(gl)EASAR_
MCL1 Phosphorylation T163 -1.997 -1.027 _RPAVLPLLELVGESGNNTSTDGSLPST(ph)PPPAEEEEDELYR_
MCL1 Ubiquitylation K194 -1.646 -1.025 _EQATGAK(gl)DTK(gl)PMGR_
MCL1 Ubiquitylation K197 -1.782 -1.165 _EQATGAK(gl)DTK(gl)PMGR_
MCL1 Ubiquitylation K308 -0.687 0.011 _DWLVK(gl)QR_
MYC Phosphorylation S20 -1.444 -1.145 _PLNVS(ph)FTNR_
MYC Phosphorylation T72 -1.699 -1.813 _FELLPT(ph)PPLS(ph)PSRR_
MYC Phosphorylation S76 -1.777 -1.435 _FELLPTPPLS(ph)PSR_
MYC Phosphorylation S81 0.459 _S(ph)GLCSPSYVAVTPFSLR_
MYC Phosphorylation S85 0.199 0.073 _SGLCS(ph)PSYVAVTPFSLR_
MYC Ubiquitylation K162 -2.475 -1.259 _LVSEK(gl)LASYQAAR_
MYC Phosphorylation S295 -0.903 _SESGS(ph)PSAGGHSKPPHSPLVLK_
MYC Phosphorylation S307 -1.486 _SES(ph)GSPSAGGHSKPPHS(ph)PLVLK_
MYC Ubiquitylation K340 -2.449 _VK(gl)LDSVR_
MYC Ubiquitylation K403 -3.432 _DQIPELENNEK(gl)APK_
PIAS1 Ubiquitylation K60 -1.191 _AGCSPAVQMKIK(gl)_
PIAS1 Ubiquitylation K341 -1.248 _VSLLCPLGK(gl)MR_
PIAS1 Phosphorylation S490 -0.898 -0.944 _RTCPSLSPTS(ph)PLNNK_
PIAS1 Phosphorylation S505 0.198 -0.250 _GILSLPHQAS(ph)PVSR_
PIK3CA Ubiquitylation K864 0.390 0.588 _NSHTIM(ox)QIQCK(gl)GGLK_
PIK3CA Ubiquitylation K868 0.204 0.651 _NSHTIM(ox)QIQCKGGLK(gl)_
PIK3CA Ubiquitylation K974 -0.273 _GAQECTK(gl)TREFER_
PRKCD Ubiquitylation K138 -0.141 _SEDEAK(gl)FPTMNR_
PRKCD Ubiquitylation K222 0.185 0.658 _DTIFQK(gl)ER_
PRKCD Phosphorylation S302 -0.240 -0.222 _S(ph)DSASSEPVGIYQGFEK_
PRKCD Phosphorylation S304 0.378 0.289 _RSDS(ph)ASSEPVGIYQGFEK_
PRKCD Phosphorylation S506 -0.213 0.200 _AS(ph)TFCGTPDYIAPEILQGLK_
PRKCD Phosphorylation T507 -0.149 0.240 _AS(ph)TFCGTPDYIAPEILQGLK_
PRKCD Ubiquitylation K641 -2.000 _DYSNFDQEFLNEK(gl)AR_
PRKCD Phosphorylation S645 0.577 0.832 _ARLS(ph)YSDK_
PRKCD Phosphorylation S647 0.886 0.853 _ARLSYS(ph)DK_
PTPN11 Ubiquitylation K124 0.562 _EAEK(gl)LLTEK_
RAC1 Ubiquitylation K115 -1.745 -0.215 _AK(gl)WYPEVR_
RAC1 Ubiquitylation K142 0.492 _LDLRDDK(gl)DTIEK_
RAC1 Ubiquitylation K152 0.099 -0.292 _K(gl)LTPITYPQGLAMAK_
RAC1 Ubiquitylation K166 -0.981 -0.655 _LTPITYPQGLAMAK(gl)EIGAVK_
RAC1 Ubiquitylation K172 1.026 0.412 _EIGAVK(gl)YLECSALTQR_
RAC1 Ubiquitylation K185 -0.113 0.578 _GLK(gl)TVFDEAIR_
RAC1 Ubiquitylation K202 -1.379 -1.447 _AVLCPPPVK(gl)KR_
RAC1 Ubiquitylation K203 -1.708 -1.447 _AVLCPPPVKK(gl)_
SOS1 Phosphorylation S1082 0.278 _IPESETESTASAPNS(ph)PR_
SOS1 Phosphorylation S1166 0.097 -0.094 _RPESAPAES(ph)SPSK_
STAT1 Phosphorylation S727 1.377 0.974 _LQTTDNLLPMS(ph)PEEFDEVSR_
STAT3 Ubiquitylation K177 0.957 _VVENLQDDFDFNYK(gl)TLK_
STAT3 Ubiquitylation K180 1.179 _TLK(gl)SQGDMQDLNGNNQSVTR_
STAT3 Ubiquitylation K244 0.262 _TLTDEELADWK(gl)R_
STAT3 Phosphorylation T714 -0.338 _FICVT(ph)PTTCSNTIDLPMS(ph)PR_
STAT3 Phosphorylation S727 -0.079 0.156 _FICVTPTTCSNTIDLPMS(ph)PR_
TIMP1 Ubiquitylation K70 1.253 -0.548 _MYK(gl)GFQALGDAADIR_


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