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Query: MAP2K6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MAP2K6 0 -2.385 1.270 -0.780

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MAP2K6 Ubiquitylation K232 0.220 _INPELNQK(gl)GYSVK_
MAP2K6 Phosphorylation T28 -1.813 -0.792 _EAFEQPQTSST(ph)PPRDLDSK_

Background Information for MAP2K6:


Pubmed-MAP2K6 »
Uniprot-MAP2K6 »
Biogrid-MAP2K6 »
ProteomicsDB-MAP2K6 »

Tumorportal-MAP2K6 »
COSMIC-MAP2K6 »
GenomeRNAi-MAP2K6 »
Genecards-MAP2K6


Protein-protein Interactions for MAP2K6
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in MAP2K6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring MAP2K6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MAP2K6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members Pathway Pathway_975 REACTOME_IL1_SIGNALING 0 0.42
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_983 ST_P38_MAPK_PATHWAY 0 0.34
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_566 BIOCARTA_HCMV_PATHWAY 0 0.18
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_1125 PID_ANTHRAX_PATHWAY 0 0.15
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0004702 receptor signaling protein serine/threonine kinase activity Database 0.1
Category members GO Category GO:0042692 muscle cell differentiation Database 0.1
Category members GO Category GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway Database 0.09
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1056 REACTOME_NOD1_2_SIGNALING_PATHWAY 0 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members GO Category GO:0051149 positive regulation of muscle cell differentiation Database 0.04
Category members GO Category GO:0002931 response to ischemia Database 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1006 PID_MAPK_TRK_PATHWAY 0 0
Category members Pathway Pathway_1038 REACTOME_MYOGENESIS 0 0
Category members Pathway Pathway_1039 PID_P38_ALPHA_BETA_PATHWAY 0 0
Category members Pathway Pathway_1044 BIOCARTA_NTHI_PATHWAY 0 0
Category members Pathway Pathway_1046 BIOCARTA_STRESS_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1054 BIOCARTA_IL1R_PATHWAY 0 0
Category members Pathway Pathway_1098 PID_P38_MKK3_6PATHWAY 0 0
Category members Pathway Pathway_1120 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION 0 0
Category members Pathway Pathway_1129 PID_P38_GAMMA_DELTA_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_423 PID_IL12_2PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_524 BIOCARTA_FMLP_PATHWAY 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_574 BIOCARTA_HDAC_PATHWAY 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members Pathway Pathway_655 PID_CXCR3_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Pathway Pathway_901 BIOCARTA_IL12_PATHWAY 0 0
Category members Pathway Pathway_937 BIOCARTA_TOLL_PATHWAY 0 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0004708 MAP kinase kinase activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006975 DNA damage induced protein phosphorylation Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0051403 stress-activated MAPK cascade Database 0
Category members GO Category GO:0060048 cardiac muscle contraction Database 0


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