RNAi screen result	RNAPII IP (MG132)	CSB IP	CSB IP (MG132)	Chrom.	Chrom. (MG132)	Ubi /Phospo	Ubi /Phospho (MG132)
W

Gene name	MGoogle Score	RNAi high	RNAi low	RNAPII-IP (MG132)	CSB-IP	CSB-IP (MG132)	Chrom.	Chrom. (MG132)
MAPK14	2	-0.160	-0.350
MAPK6	1	2.490	-0.970		-3.989
MAPK6	1	2.490	-0.970					0.892
RAF1	1	2.020	-1.230
KRAS	1	-0.510	0.620				1.031	0.887
KRAS	1	-0.510	0.620				0.246	-0.346
MAP2K1	1	-1.590	2.780
NRAS	1	1.810	-0.720				0.246	-0.346
MAPK8IP2	0	1.730	-1.220
MAP2K3	0	0.780	-0.600
MAP2K4	0	-0.300	0.320
FGFR3	0	-1.120	1.390
MEF2A	0	0.820	-0.530
MEF2A	0	0.820	-0.530
MAPK1	0	-0.500	0.330					0.892
MAPK3	0							0.892
MAPK4	0							0.892
FGFR1	0	0.210	0.150
MEF2C	0	-0.980	1.550
MEF2C	0	-0.980	1.550
MAPKAPK5	0	1.100	-0.730
BRAP	0	1.580	-1.050
MAPK3	0
TGFB1	0	-0.550	1.050
CAV1	0	1.150	-0.150
CAV1	0	1.150	-0.150
CAV1	0	1.150	-0.150
MAP2K6	0	1.270	-0.780
RAPGEF2	0	-0.860	1.560
CAMKK2	0	1.040	-0.430
CAMKK2	0	1.040	-0.430
MAP2K2	0	-0.610	0.080
MAP2K2	0	-0.610	0.080
FGF13	0	1.100	-1.060
MEN1	0	1.080	-1.150	0.101			0.684	-0.063
MEN1	0	1.080	-1.150			0.395
MEN1	0	1.080	-1.150
TAOK3	0	-0.440	0.370
TAOK3	0	-0.440	0.370					1.169
MAP3K7	0	-1.120	1.140	-1.048
MYC	0	0.170	0.550	-2.443	-0.949	-0.454		-1.290
EGFR	0	-0.580	0.520				0.513	0.090
RASGRP3	0	0.570	0.240
BRAF	0
YWHAB	0				0.628	-0.543
YWHAB	0			0.507			0.271	0.503
MAP3K2	0	-1.220	1.960
CDK1	0	-0.370	0.080	-0.202	-0.884	-0.107	-0.097	-0.501
HRAS	0	1.470	-0.520
LRRK2	0	0.530	-0.620	-0.240
NF1	0	1.000	-0.500				0.444	-0.190
MAP3K5	0	0.710	-0.770
MAP3K3	0	0.830	-0.050

Gene name	PTM type	PTM site	UV	UV (MG132)	Sequence
BRAF	Phosphorylation	S151	-0.685	-0.629	_SNPKS(ph)PQKPIVR_
BRAF	Phosphorylation	S363	-0.023	-0.241	_S(ph)SSAPNVHINTIEPVNIDDLIR_
BRAF	Phosphorylation	S365	-0.286	0.012	_SSS(ph)APNVHINTIEPVNIDDLIR_
BRAF	Phosphorylation	S399	-0.890	-0.527	_GDGGSTTGLS(ph)ATPPASLPGSLTNVK_
BRAF	Phosphorylation	T401	-0.525		_GDGGSTTGLSAT(ph)PPASLPGSLTNVK_
BRAF	Phosphorylation	S446	0.246	0.349	_RDS(ph)SDDWEIPDGQITVGQR_
BRAF	Phosphorylation	S447	0.579	0.623	_RDSS(ph)DDWEIPDGQITVGQR_
BRAF	Phosphorylation	S729	0.208	0.219	_SAS(ph)EPSLNR_
BRAP	Phosphorylation	S157	0.033	-0.074	_ECINAAPDS(ph)PSK_
BRAP	Phosphorylation	S159	-0.208	-0.105	_ECINAAPDSPS(ph)K_
BRAP	Ubiquitylation	K425	0.929		_TDGK(gl)IVQYECEGDTCQEEK_
BRAP	Ubiquitylation	K466	0.347		_IYWENK(gl)IVR_
CAMKK2	Phosphorylation	S74	0.752	0.924	_KLS(ph)LQER_
CAMKK2	Phosphorylation	S100	0.985	0.940	_KLS(ph)LQER_
CAMKK2	Phosphorylation	S495		0.812	_RS(ph)FGNPFEGSR_
CAMKK2	Phosphorylation	S511		0.155	_SLS(ph)APGNLLTK_
CAV1	Ubiquitylation	K5	0.591	0.963	_(ac)SGGK(gl)YVDSEGHLYTVPIR_
CAV1	Phosphorylation	S6	0.836	0.688	_(ac)ADELS(ph)EKQVYDAHTK_
CAV1	Ubiquitylation	K8	0.244	0.734	_(ac)ADELSEK(gl)QVYDAHTK_
CAV1	Ubiquitylation	K26	0.724	0.894	_EQGNIYK(gl)PNNK_
CAV1	Ubiquitylation	K30	-0.008	0.317	_EQGNIYKPNNK(gl)AMADELSEK_
CAV1	Ubiquitylation	K39	0.690	1.170	_AMADELSEK(gl)QVYDAHTK_
CAV1	Phosphorylation	S76	0.607	0.527	_AMADELS(ph)EK_
CAV1	Ubiquitylation	K176		-0.259	_INLQK(gl)EI_
CDK1	Ubiquitylation	K6	0.011	-0.784	_(ac)M(ox)EDYTK(gl)IEK_
CDK1	Ubiquitylation	K20	-0.327	-0.270	_IGEGTYGVVYK(gl)GR_
CDK1	Ubiquitylation	K33	0.736	0.239	_TTGQVVAMK(gl)K_
CDK1	Ubiquitylation	K34		-0.306	_TTGQVVAMKK(gl)_
CDK1	Ubiquitylation	K58	0.312	-0.262	_EISLLK(gl)ELR_
CDK1	Ubiquitylation	K136		-0.468	_DLK(gl)PQNLLIDDK(gl)GTIK_
CDK1	Ubiquitylation	K145	0.161	-0.954	_DLKPQNLLIDDK(gl)GTIK_
CDK1	Ubiquitylation	K149		-0.038	_GTIK(gl)LADFGLAR_
CDK1	Ubiquitylation	K251	-0.047	-1.236	_WK(gl)PGSLASHVK_
CDK1	Ubiquitylation	K280	0.179	-1.210	_MLIYDPAK(gl)R_
EGFR	Phosphorylation	T693	0.486	-0.139	_ELVEPLT(ph)PSGEAPNQALLR_
EGFR	Phosphorylation	S991		-0.041	_MHLPS(ph)PTDSNFYR_
FGF13	Ubiquitylation	K57	-0.429	0.063	_AK(gl)CHEIFCCPLK_
FGF13	Phosphorylation	S224	0.090	0.488	_VAMYKEPS(ph)LHDLTEFSR_
FGFR1	Ubiquitylation	K510	1.047	-0.221	_VTK(gl)VAVK_
FGFR3	Ubiquitylation	K205		-0.115	_IGGIK(gl)LR_
HRAS	Ubiquitylation	K170	-1.005		_K(gl)LNPPDESGPGCMSCK_
KRAS	Ubiquitylation	K128	1.528	1.433	_TVDTK(gl)QAHELAK_
KRAS	Ubiquitylation	K235	0.591	0.087	_TVDTK(gl)QAQDLAR_
KRAS	Ubiquitylation	K254	-0.450	-0.156	_SYGIPFIETSAK(gl)TR_
MAP2K1	Ubiquitylation	K192	-0.205	-0.241	_DVK(gl)PSNILVNSR_
MAP2K1	Phosphorylation	S385		0.066	_RSDAEEVDFAGWLCSTIGLNQPS(ph)TPTHAAGV_
MAP2K1	Phosphorylation	T386		0.377	_RSDAEEVDFAGWLCSTIGLNQPST(ph)PTHAAGV_
MAP2K2	Phosphorylation	S23	0.873	0.258	_RKPVLPALTINPTIAEGPS(ph)PTSEGASEANLVDLQK_
MAP2K2	Phosphorylation	T25		0.439	_RKPVLPALTINPTIAEGPSPT(ph)SEGASEANLVDLQK_
MAP2K2	Ubiquitylation	K192	-0.205	-0.241	_DVK(gl)PSNILVNSR_
MAP2K2	Phosphorylation	S293		-0.361	_ELEAIFGRPVVDGEEGEPHS(ph)ISPR_
MAP2K2	Phosphorylation	S295	-0.234	0.026	_ELEAIFGRPVVDGEEGEPHSIS(ph)PR_
MAP2K2	Phosphorylation	T394	0.570	0.158	_LNQPGT(ph)PTR_
MAP2K3	Ubiquitylation	K84	0.045	-0.277	_GAYGVVEK(gl)VR_
MAP2K3	Ubiquitylation	K232		-1.394	_TMDAGCK(gl)PYMAPER_
MAP2K3	Ubiquitylation	K247	0.065	-0.737	_INPELNQK(gl)GYNVK_
MAP2K4	Phosphorylation	S80		0.441	_LRTHS(ph)IESSGK_
MAP2K6	Phosphorylation	T28	-1.813	-0.792	_EAFEQPQTSST(ph)PPRDLDSK_
MAP2K6	Ubiquitylation	K232		0.220	_INPELNQK(gl)GYSVK_
MAP3K2	Phosphorylation	S153	0.506	-0.231	_RLS(ph)IIGPTSR_
MAP3K2	Phosphorylation	S163	-0.910	-0.776	_DRS(ph)SPPPGYIPDELHQVAR_
MAP3K2	Phosphorylation	S164	-0.743	-0.966	_DRS(ph)SPPPGYIPDELHQVAR_
MAP3K2	Phosphorylation	S239	-0.284	-0.618	_AQS(ph)YPDNHQEFSDYDNPIFEK_
MAP3K2	Phosphorylation	S331		0.008	_RRGS(ph)DIDNPTLTVM(ox)DISPPSR_
MAP3K3	Phosphorylation	S166		-0.325	_HLS(ph)VSSQNPGR_
MAP3K3	Phosphorylation	S175	0.120	-0.091	_S(ph)SPPPGYVPER_
MAP3K3	Phosphorylation	S176	0.120	-0.091	_S(ph)SPPPGYVPER_
MAP3K3	Phosphorylation	S250	-0.070		_AQS(ph)FPDNR_
MAP3K5	Phosphorylation	S1066		-1.241	_SISLPVPVLVEDTSSSSEYGSVS(ph)PDTELKVDPFSFK_
MAP3K5	Phosphorylation	S1113	-1.408	-0.562	_TLFLGIPDENFEDHSAPPS(ph)PEEK_
MAP3K7	Phosphorylation	S374	0.149	-0.337	_GS(ph)SVESLPPTSEGK_
MAP3K7	Phosphorylation	S375	0.171	-0.087	_GSS(ph)VESLPPTSEGK_
MAP3K7	Phosphorylation	S389	1.072	1.445	_RMS(ph)ADMSEIEAR_
MAP3K7	Phosphorylation	S439	0.246	0.198	_S(ph)IQDLTVTGTEPGQVSSR_
MAP3K7	Ubiquitylation	K474	-0.385	-0.242	_MITTSGPTSEK(gl)PTR_
MAP3K7	Ubiquitylation	K589	-0.104		_SLSTYYQQCK(gl)K_
MAP3K7	Ubiquitylation	K590	-0.551	0.560	_K(gl)QLEVIR_
MAPK1	Phosphorylation	Y187	-0.935	-2.332	_VADPDHDHTGFLTEY(ph)VATR_
MAPK1	Ubiquitylation	K203	-0.021	-0.779	_APEIMLNSK(gl)GYTK_
MAPK14	Phosphorylation	S2	3.221	3.623	_(ac)S(ph)QERPTFYR_
MAPK14	Phosphorylation	T180	0.958	1.087	_HTDDEM(ox)T(ph)GYVATR_
MAPK14	Phosphorylation	Y182	1.388	1.374	_HTDDEM(ox)TGY(ph)VATR_
MAPK14	Ubiquitylation	K249	0.073	-1.380	_LVGTPGAELLKK(gl)_
MAPK3	Phosphorylation	Y187	-0.935	-2.332	_VADPDHDHTGFLTEY(ph)VATR_
MAPK3	Ubiquitylation	K203	-0.021	-0.779	_APEIMLNSK(gl)GYTK_
MAPK3	Phosphorylation	Y204	-0.807	-2.487	_IADPEHDHTGFLTEY(ph)VATR_
MAPK3	Ubiquitylation	K289		-0.608	_NYLQSLPSKTK(gl)_
MAPK4	Phosphorylation	Y187	-0.935	-2.332	_VADPDHDHTGFLTEY(ph)VATR_
MAPK4	Ubiquitylation	K203	-0.021	-0.779	_APEIMLNSK(gl)GYTK_
MAPK6	Phosphorylation	Y187	-0.935	-2.332	_VADPDHDHTGFLTEY(ph)VATR_
MAPK6	Phosphorylation	S189	-0.821	-0.414	_GHLS(ph)EGLVTK_
MAPK6	Ubiquitylation	K203	-0.021	-0.779	_APEIMLNSK(gl)GYTK_
MAPK6	Ubiquitylation	K480	-1.705		_LIIDLSNWK(gl)EQSK_
MAPK6	Ubiquitylation	K517	-1.941	-0.759	_AQIALEEASQQLAGK(gl)ER_
MAPK8IP2	Ubiquitylation	K674	-0.899	0.671	_DLLGSK(gl)R_
MAPKAPK5	Phosphorylation	T182	-0.559	-0.706	_IDQGDLM(ox)T(ph)PQFTPYYVAPQVLEAQR_
MEF2A	Ubiquitylation	K23		-0.140	_QVTFTK(gl)R_
MEF2A	Phosphorylation	S235	0.664	-0.092	_AS(ph)PNLIGATGANSLGK_
MEF2A	Phosphorylation	T253		-1.271	_VMPT(ph)KSPPPPGGGNLGMNSR_
MEF2A	Phosphorylation	S255		-1.235	_VMPTKS(ph)PPPPGGGNLGMNSR_
MEF2A	Phosphorylation	S408	-0.173	-0.049	_SEPIS(ph)PPRDR_
MEF2A	Phosphorylation	S494	-0.858	-1.232	_GDFHSPIVLGRPPNTEDRES(ph)PSVK_
MEF2C	Ubiquitylation	K23		-0.140	_QVTFTK(gl)R_
MEF2C	Phosphorylation	S240	0.008	0.302	_NS(ph)PGLLVSPGNLNK_
MEF2C	Phosphorylation	S406	0.272	0.338	_SEPVS(ph)PPRDR_
MEN1	Ubiquitylation	K8	-1.132	0.088	_AAQK(gl)TLFPLR_
MEN1	Phosphorylation	S218		-0.820	_RES(ph)KPEEPPPPK_
MYC	Phosphorylation	S20	-1.444	-1.145	_PLNVS(ph)FTNR_
MYC	Phosphorylation	T72	-1.699	-1.813	_FELLPT(ph)PPLS(ph)PSRR_
MYC	Phosphorylation	S76	-1.777	-1.435	_FELLPTPPLS(ph)PSR_
MYC	Phosphorylation	S81		0.459	_S(ph)GLCSPSYVAVTPFSLR_
MYC	Phosphorylation	S85	0.199	0.073	_SGLCS(ph)PSYVAVTPFSLR_
MYC	Ubiquitylation	K162	-2.475	-1.259	_LVSEK(gl)LASYQAAR_
MYC	Phosphorylation	S295		-0.903	_SESGS(ph)PSAGGHSKPPHSPLVLK_
MYC	Phosphorylation	S307		-1.486	_SES(ph)GSPSAGGHSKPPHS(ph)PLVLK_
MYC	Ubiquitylation	K340		-2.449	_VK(gl)LDSVR_
MYC	Ubiquitylation	K403		-3.432	_DQIPELENNEK(gl)APK_
NF1	Ubiquitylation	K471		0.218	_MAPSLTFKEK(gl)_
NF1	Phosphorylation	S864		-0.458	_SNSGLATYS(ph)PPMGPVSER_
NF1	Phosphorylation	T2514		0.076	_GSEGYLAATYPTVGQT(ph)SPR_
NF1	Phosphorylation	S2515	0.071	0.316	_GSEGYLAATYPTVGQTS(ph)PR_
NF1	Phosphorylation	S2543	0.698	0.655	_S(ph)FDHLISDTK_
NRAS	Ubiquitylation	K128	1.528	1.433	_TVDTK(gl)QAHELAK_
RAF1	Phosphorylation	S29	0.028	-0.571	_DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1	Phosphorylation	T31	0.028	-0.669	_DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1	Phosphorylation	S244		0.053	_YSTPHAFTFNTSS(ph)PSSEGSLSQR_
RAF1	Phosphorylation	S259	-0.069	0.054	_STS(ph)TPNVHM(ox)VSTTLPVDSR_
RAF1	Phosphorylation	S301		-0.651	_SHSESASPSALSSSPNNLS(ph)PTGWSQPK_
RAF1	Phosphorylation	T303		-0.664	_SHSESASPSALSSSPNNLSPT(ph)GWSQPK_
RAF1	Phosphorylation	S497		-0.449	_SRWS(ph)GSQQVEQPTGSVLWMAPEVIR_
RAF1	Phosphorylation	S621	0.212	0.271	_SAS(ph)EPSLHR_
RAF1	Phosphorylation	S642	-0.197	0.463	_AAHTEDINACTLTTS(ph)PR_
RAPGEF2	Phosphorylation	S1022	0.043	-0.570	_SETS(ph)PVAPR_
RAPGEF2	Phosphorylation	S1080	-0.612		_DLPPFGINS(ph)PQALK_
RASGRP3	Phosphorylation	S390	0.183	0.695	_SPTS(ph)PTTPNK_
TAOK3	Phosphorylation	S9	-0.793	0.108	_AGS(ph)LKDPEIAELFFKEDPEK_
TAOK3	Phosphorylation	S324	0.159	0.189	_NGPLNES(ph)QEDEEDSEHGTSLNR_
TAOK3	Phosphorylation	S421	-0.535	-0.355	_ASDPQS(ph)PPQVSR_
TAOK3	Ubiquitylation	K587	0.700		_QEWLSK(gl)QK_
TGFB1	Ubiquitylation	K50		-0.557	_GQILSK(gl)LR_
YWHAB	Ubiquitylation	K11	1.057	1.322	_(ac)TMDKSELVQK(gl)AK_
YWHAB	Ubiquitylation	K13	0.060	0.388	_AK(gl)LAEQAER_
YWHAB	Ubiquitylation	K70	0.558	-0.175	_VISSIEQK(gl)TER_
YWHAB	Ubiquitylation	K140		0.531	_YLSEVASGDNK(gl)QTTVSNSQQAYQEAFEISKK_
YWHAB	Ubiquitylation	K159	0.300		_QTTVSNSQQAYQEAFEISK(gl)K_
YWHAB	Ubiquitylation	K160	-0.439	-0.371	_K(gl)EMQPTHPIR_