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Query: FGFR3

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FGFR3 0 1.275 -1.120 1.390

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FGFR3 Ubiquitylation K205 -0.115 _IGGIK(gl)LR_

Background Information for FGFR3:


Pubmed-FGFR3 »
Uniprot-FGFR3 »
Biogrid-FGFR3 »
ProteomicsDB-FGFR3 »

Tumorportal-FGFR3 »
COSMIC-FGFR3 »
GenomeRNAi-FGFR3 »
Genecards-FGFR3


Protein-protein Interactions for FGFR3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARRDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGFR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM231 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FGFR3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members Immunoglobulin IPR013151 0.23
Category members Ig_sub2 IPR003598 0.21
Category members Ig_I-set IPR013098 0.13
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members FGF_rcpt_fam IPR016248 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring FGFR3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FGFR3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0045597 positive regulation of cell differentiation Database 0.45
Category members GO Category GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein Database 0.44
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_590 REACTOME_PI_3K_CASCADE 0 0.37
Category members Pathway Pathway_528 REACTOME_SIGNALING_BY_FGFR_MUTANTS 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0014003 oligodendrocyte development Database 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0060349 bone morphogenesis Database 0.17
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members Disease phenotype Giant_cell_glioblastoma Giant cell glioblastoma Database 0.14
Category members Disease phenotype Gliosarcoma Gliosarcoma Database 0.14
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members GO Category GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity Database 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0022010 central nervous system myelination Database 0.08
Category members GO Category GO:0045839 negative regulation of mitosis Database 0.08
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0035988 chondrocyte proliferation Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0001958 endochondral ossification Database 0.04
Category members GO Category GO:0010518 positive regulation of phospholipase activity Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0002089 lens morphogenesis in camera-type eye Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0048678 response to axon injury Database 0.01
Category members Pathway Pathway_1088 REACTOME_SHC_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_1089 REACTOME_SIGNALING_BY_FGFR3_MUTANTS 0 0
Category members Pathway Pathway_1091 REACTOME_FRS2_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_1092 REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_261 REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_783 REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 0 0
Category members Disease phenotype BLADDER_CANCER BLADDER CANCER Database 0
Category members Disease phenotype Cutis_gyrata_-_acanthosis_nigricans_-_craniosynostosis Cutis gyrata - acanthosis nigricans - craniosynostosis Database 0
Category members Disease phenotype Isolated_brachycephaly Isolated brachycephaly Database 0
Category members Disease phenotype Isolated_cloverleaf_skull_syndrome Isolated cloverleaf skull syndrome Database 0
Category members Disease phenotype Isolated_plagiocephaly Isolated plagiocephaly Database 0
Category members Disease phenotype KERATOSIS_SEBORRHEIC KERATOSIS SEBORRHEIC Database 0
Category members Disease phenotype lacrimo-auriculo-dento-digital_syndrome_(LADDS) lacrimo-auriculo-dento-digital syndrome (LADDS) Database 0
Category members Disease phenotype LACRIMOAURICULODENTODIGITAL_SYNDROME LACRIMOAURICULODENTODIGITAL SYNDROME Database 0
Category members Disease phenotype MYELOMA_MULTIPLE MYELOMA MULTIPLE Database 0
Category members Disease phenotype SAETHRE-CHOTZEN_SYNDROME SAETHRE-CHOTZEN SYNDROME Database 0
Category members Disease phenotype TESTICULAR_GERM_CELL_TUMOR TESTICULAR GERM CELL TUMOR Database 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0002009 morphogenesis of an epithelium Database 0
Category members GO Category GO:0003416 endochondral bone growth Database 0
Category members GO Category GO:0005007 fibroblast growth factor-activated receptor activity Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0007259 JAK-STAT cascade Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0017134 fibroblast growth factor binding Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0021762 substantia nigra development Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0045879 negative regulation of smoothened signaling pathway Database 0
Category members GO Category GO:0048546 digestive tract morphogenesis Database 0
Category members GO Category GO:0048712 negative regulation of astrocyte differentiation Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0051216 cartilage development Database 0
Category members GO Category GO:0060113 inner ear receptor cell differentiation Database 0
Category members GO Category GO:0060385 axonogenesis involved in innervation Database 0
Category members GO Category GO:0070307 lens fiber cell development Database 0


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