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negative regulation of smoothened signaling pathway
(GO:0045879)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
FGFR3 0 -1.120 1.390
SALL1 0 -0.080 0.063 0.213 0.247 0.009
GLI3 0 -0.980 1.650
SUFU 0 1.190 -0.990
RUNX2 0
RB1 0 1.180 -1.070 0.429 0.755
RB1 0 1.180 -1.070
IFT122 0 0.590 -0.240
IFT122 0 1.590 -0.690
BTRC 0 -0.780 0.690 0.532 -1.791 0.313
KIF7 0 -0.700 0.600 0.688
KIF7 0 0.280 -0.500 0.688
PTCH1 0 0.630 -0.690
SALL3 0 -0.080 0.063 0.213 0.247 0.009

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
BTRC Ubiquitylation K466 0.325 _IVSGAYDGKIK(gl)_
FGFR3 Ubiquitylation K205 -0.115 _IGGIK(gl)LR_
GLI3 Phosphorylation S664 -0.582 -0.252 _S(ph)PGRPTQGALGEQQDLSNTTSK_
IFT122 Ubiquitylation K804 -0.101 _MLITK(gl)QADWAR_
IFT122 Ubiquitylation K1084 -0.071 _FQK(gl)SIELGTLTIR_
KIF7 Ubiquitylation K1208 0.476 _YMWINQELK(gl)QK_
PTCH1 Ubiquitylation K904 -0.390 _DKPIDISQLTK(gl)QR_
RB1 Phosphorylation S69 -3.602 -3.397 _TAATAAAAAAEPPAPPPPPPPEEDPEQDS(ph)GPEDLPLVR_
RB1 Ubiquitylation K97 -0.546 _LK(gl)IPDHVR_
RB1 Phosphorylation T388 0.005 0.116 _TLQTDSIDSFETQRT(ph)PR_
RB1 Phosphorylation T405 -0.851 -0.901 _KSNLDEEVNVIPPHT(ph)PVR_
RB1 Phosphorylation S820 -0.019 _S(ph)PYKFPSSPLR_
RB1 Ubiquitylation K823 -2.214 _SPYK(gl)FPSSPLR_
RB1 Phosphorylation S827 0.824 0.111 _FPSS(ph)PLR_
RB1 Phosphorylation S839 -0.701 -1.045 _IPGGNIYIS(ph)PLKS(ph)PYK_
RB1 Ubiquitylation K842 -0.751 _IPGGNIYISPLK(gl)SPYK_
RB1 Phosphorylation S843 -0.701 -0.022 _IPGGNIYIS(ph)PLKS(ph)PYK_
RB1 Ubiquitylation K846 -2.084 _SPYK(gl)ISEGLPTPTK_
RB1 Phosphorylation T853 0.039 -0.555 _ISEGLPT(ph)PTKM(ox)T(ph)PR_
RB1 Ubiquitylation K856 -1.350 _ISEGLPTPTK(gl)MTPR_
RB1 Phosphorylation T858 -0.782 0.564 _ISEGLPT(ph)PTKMT(ph)PR_
RB1 Ubiquitylation K879 -0.187 _FQK(gl)INQMVCNSDR_
RUNX2 Phosphorylation S96 0.504 -0.399 _RFS(ph)PPSSSLQPGK_
RUNX2 Ubiquitylation K244 0.258 _NASAVMK(gl)NQVAR_
SALL1 Phosphorylation S1119 -1.156 -1.235 _DTPTSHVPSGPLSSSATS(ph)PVLLPALPR_
SALL3 Phosphorylation S1119 -1.156 -1.235 _DTPTSHVPSGPLSSSATS(ph)PVLLPALPR_
SUFU Ubiquitylation K303 -0.015 _RLSGK(gl)DTEQIR_
SUFU Ubiquitylation K321 -1.917 -1.398 _GLEINSK(gl)PVLPPINPQR_
SUFU Phosphorylation S346 0.344 0.498 _KDS(ph)LESDSSTAIIPHELIR_


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