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Query: RUNX2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RUNX2 0 0.363

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RUNX2 Phosphorylation S96 0.504 -0.399 _RFS(ph)PPSSSLQPGK_
RUNX2 Ubiquitylation K244 0.258 _NASAVMK(gl)NQVAR_

Background Information for RUNX2:


Pubmed-RUNX2 »
Uniprot-RUNX2 »
Biogrid-RUNX2 »
ProteomicsDB-RUNX2 »

Tumorportal-RUNX2 »
COSMIC-RUNX2 »
GenomeRNAi-RUNX2 »
Genecards-RUNX2


Protein-protein Interactions for RUNX2
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in RUNX2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members AML1_Runt IPR000040 0
Category members p53-like_TF_DNA-bd IPR008967 0
Category members Runt_dom IPR013524 0
Category members RunxI_C_dom IPR013711 0
Category members TF_Runt-rel_RUNX IPR016554 0


Protein complexes (CORUM database) featuring RUNX2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RUNX2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0030509 BMP signaling pathway Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0002076 osteoblast development Database 0.13
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0001958 endochondral ossification Database 0.04
Category members GO Category GO:0002063 chondrocyte development Database 0.04
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_939 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION 0 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0002051 osteoblast fate commitment Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0030217 T cell differentiation Database 0
Category members GO Category GO:0030278 regulation of ossification Database 0
Category members GO Category GO:0032332 positive regulation of chondrocyte differentiation Database 0
Category members GO Category GO:0035115 embryonic forelimb morphogenesis Database 0
Category members GO Category GO:0040036 regulation of fibroblast growth factor receptor signaling pathway Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0042487 regulation of odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0043425 bHLH transcription factor binding Database 0
Category members GO Category GO:0045667 regulation of osteoblast differentiation Database 0
Category members GO Category GO:0045669 positive regulation of osteoblast differentiation Database 0
Category members GO Category GO:0045879 negative regulation of smoothened signaling pathway Database 0
Category members GO Category GO:0048469 cell maturation Database 0
Category members GO Category GO:0048705 skeletal system morphogenesis Database 0
Category members GO Category GO:0048863 stem cell differentiation Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0


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