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PID_HES_HEY_PATHWAY
(Pathway_119)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
SPEN 2 0.970 -0.180 -0.126 -0.082
PARP1 2
PARP1 2 -0.200 0.357 0.412 0.442 0.293
KDM1A 1 -1.020 1.190 1.814 0.225
KDM1A 1 -1.020 1.190 0.355 0.031 0.593
HDAC1 1 -1.980 4.450
HDAC1 1 -1.980 4.450 -0.122 0.307 0.969 0.094 0.191
NCOR2 1 1.850 -1.050
NCOR2 1 1.850 -1.050 0.037 -1.127
CREBBP 0 0.840 -0.950 -3.889 -1.071
TCF3 0 0.270 -0.020
NCOA1 0 1.240 -0.460
EP300 0 -1.210 1.320 -1.089 -1.694 -0.723
HIF1A 0 -0.480 0.400
YY1 0 -0.370 0.560 0.179 0.557 0.050 -0.096 0.076
RBBP8 0 0.120 0.020
HES1 0 -0.940 0.860
TWIST1 0 -0.640 1.150
RUNX2 0
KDR 0 0.860 -0.680
GATA4 0 -0.670 0.350
RB1 0 1.180 -1.070 0.429 0.755
RB1 0 1.180 -1.070
NCOR1 0 -0.820 1.130 -0.827 -0.215 0.037
GATA6 0 -0.210 -0.020 -0.027 -0.582 -0.834
ARNT 0 1.120 -0.500
CAMK2D 0 -0.260 0.500 -0.654 0.073
CAMK2D 0 -0.260 0.500 -0.619 0.544 0.125
CAMK2D 0 -0.260 0.500
CTBP1 0 -0.410 0.390
CTBP1 0 -0.410 0.390 -0.293 -0.875 0.361 0.407 -0.049
CTBP1 0 -0.410 0.390 1.494 -0.398 0.504 0.897 -0.123
MAML1 0 0.470 -0.390
RBPJ 0 1.900 -0.160 -0.367 0.284 0.723 -0.090 0.134
STAT3 0 0.200 -1.270 0.334
TLE1 0 0.270 0.000 0.116

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ARNT Phosphorylation S81 1.133 _FARS(ph)DDEQSSADKER_
ARNT Ubiquitylation K421 -2.502 _DSFQQVVK(gl)LK_
CAMK2D Ubiquitylation K251 -0.437 _DLINK(gl)MLTINPAK_
CAMK2D Phosphorylation S330 0.412 0.370 _KPDGVKES(ph)TESSNTTIEDEDVK_
CAMK2D Phosphorylation T331 -0.174 _KPDGVKES(ph)TESSNTTIEDEDVK_
CAMK2D Phosphorylation T336 0.615 0.376 _ESTESSNT(ph)TIEDEDVK_
CAMK2D Phosphorylation T337 0.450 _ESTESSNTT(ph)IEDEDVK_
CREBBP Phosphorylation S2093 0.037 0.097 _SIS(ph)PSALQDLLR_
CTBP1 Ubiquitylation K279 0.443 _GGLVDEK(gl)ALAQALK_
CTBP1 Ubiquitylation K286 0.130 0.008 _ALAQALK(gl)EGR_
CTBP1 Phosphorylation S492 -1.548 _YPPGIVGVAPGGLPAAM(ox)EGIIPGGIPVTHNLPTVAHPS(ph)QAPSPNQPTK_
EP300 Phosphorylation S1038 -0.672 -0.349 _TEIKEEEDQPSTSATQSS(ph)PAPGQSK_
EP300 Phosphorylation S1726 0.994 0.627 _LGLGLDDESNNQQAAATQS(ph)PGDSRR_
EP300 Phosphorylation S2328 -1.092 0.725 _PQSQPPHSSPS(ph)PR_
GATA4 Phosphorylation S109 -0.520 -0.425 _FS(ph)FPGTTGSLAAAAAAAAAR_
GATA4 Phosphorylation S407 -0.185 0.124 _LS(ph)PQGYASPVSQSPQTSSK_
HDAC1 Ubiquitylation K50 0.036 _K(gl)MEIYRPHK_
HDAC1 Ubiquitylation K66 -0.593 _ANAEEMTK(gl)YHSDDYIK_
HDAC1 Ubiquitylation K74 0.620 -1.473 _YHSDDYIK(gl)FLR_
HDAC1 Ubiquitylation K89 0.749 -0.241 _SIRPDNMSEYSK(gl)QMQR_
HDAC1 Phosphorylation S393 -1.133 -1.144 _M(ox)LPHAPGVQM(ox)QAIPEDAIPEES(ph)GDEDEDDPDKR_
HDAC1 Phosphorylation S409 1.326 1.144 _ISICS(ph)SDKR_
HDAC1 Phosphorylation S410 1.326 1.144 _ISICS(ph)SDKR_
HDAC1 Ubiquitylation K412 0.642 -0.744 _ISICSSDK(gl)R_
HES1 Ubiquitylation K66 0.212 _TLILDALK(gl)K_
HES1 Ubiquitylation K67 0.212 _TLILDALK(gl)K_
HES1 Ubiquitylation K109 -0.891 _AQMTAALSTDPSVLGK(gl)YR_
HIF1A Ubiquitylation K10 -1.686 _(ac)MEGAGGANDK(gl)K_
HIF1A Ubiquitylation K11 -1.686 _(ac)MEGAGGANDK(gl)K_
HIF1A Ubiquitylation K173 -0.662 _MK(gl)CTLTSR_
HIF1A Ubiquitylation K186 -0.590 _TMNIK(gl)SATWK_
HIF1A Ubiquitylation K252 -0.784 _HSLDM(ox)K(gl)FSYCDER_
HIF1A Ubiquitylation K371 -0.508 _PVESSDMK(gl)MTQLFTK_
HIF1A Ubiquitylation K378 -0.077 _MTQLFTK(gl)VESEDTSSLFDK_
HIF1A Ubiquitylation K390 -0.348 _VESEDTSSLFDK(gl)LKK_
HIF1A Ubiquitylation K392 -0.546 _VESEDTSSLFDKLK(gl)_
HIF1A Ubiquitylation K393 -0.451 _VESEDTSSLFDKLKK(gl)_
HIF1A Ubiquitylation K710 -1.696 _TTVPEEELNPK(gl)ILALQNAQR_
KDM1A Phosphorylation S69 -2.048 -2.645 _KEPPRAS(ph)PPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGR_
KDM1A Phosphorylation T88 -1.832 _KEPPRASPPGGLAEPPGSAGPQAGPT(ph)VVPGSATPM(ox)ETGIAETPEGR_
KDM1A Phosphorylation S126 0.780 0.501 _EMDES(ph)LANLSEDEYYS(ph)EEER_
KDM1A Phosphorylation S131 0.204 0.473 _EM(ox)DESLANLS(ph)EDEYYS(ph)EEER_
KDM1A Phosphorylation S137 0.122 0.511 _EM(ox)DESLANLS(ph)EDEYYS(ph)EEER_
KDM1A Phosphorylation S166 -2.328 -2.624 _KLPPPPPQAPPEEENES(ph)EPEEPSGVEGAAFQSR_
KDM1A Ubiquitylation K296 -0.820 _IKPLPTK(gl)K_
KDM1A Ubiquitylation K297 -0.820 _IKPLPTK(gl)K_
KDM1A Ubiquitylation K507 -1.073 _DITAEFLVKSK(gl)_
KDR Ubiquitylation K1064 -1.119 _DIYK(gl)DPDYVR_
MAML1 Phosphorylation S45 1.371 0.474 _YEAVS(ph)PERLELER_
NCOA1 Phosphorylation S22 0.503 0.810 _KGS(ph)PCDTLASSTEK_
NCOR1 Phosphorylation S1195 -0.029 0.716 _MPIEDS(ph)SPEKGREEAASK_
NCOR1 Phosphorylation S1196 0.087 0.141 _MPIEDSS(ph)PEKGR_
NCOR1 Phosphorylation S1472 0.700 0.536 _AQLS(ph)PGIYDDTSAR_
NCOR1 Phosphorylation S1977 -0.959 -0.974 _YETPSDAIEVIS(ph)PASSPAPPQEK_
NCOR1 Ubiquitylation K1998 -2.086 _LQTYQPEVVK(gl)ANQAENDPTR_
NCOR1 Phosphorylation S2120 0.148 0.154 _VS(ph)PENLVDK_
NCOR1 Phosphorylation S2151 -1.006 -0.922 _SHVSSEPYEPIS(ph)PPQVPVVHEK_
NCOR1 Phosphorylation S2184 0.120 0.226 _S(ph)PGSISYLPSFFTK_
NCOR1 Phosphorylation S2187 0.396 _SPGS(ph)ISYLPSFFTK_
NCOR2 Phosphorylation S939 -0.637 _LLS(ph)PRPSLLTPTGDPR_
NCOR2 Phosphorylation S943 -0.740 _LLSPRPS(ph)LLTPTGDPR_
NCOR2 Phosphorylation S956 -0.223 -0.308 _ANAS(ph)PQKPLDLK_
NCOR2 Phosphorylation S1023 -0.334 _S(ph)RSPAPPADKEAFAAEAQK_
NCOR2 Phosphorylation S1025 1.950 _SRS(ph)PAPPADKEAFAAEAQK_
NCOR2 Phosphorylation T1383 -1.746 -2.157 _EGT(ph)PPPPPPSR_
NCOR2 Phosphorylation S1479 0.325 -0.132 _SLIGS(ph)PGR_
NCOR2 Phosphorylation S1778 -0.687 _HSSSPLS(ph)PGGPTHLTKPTTTSSSER_
NCOR2 Phosphorylation S1970 -0.321 _SGLEPAS(ph)SPSK_
NCOR2 Phosphorylation S1971 -0.480 _SGLEPASS(ph)PSK_
NCOR2 Phosphorylation S2223 -0.074 -1.140 _TSVLGGGEDGIEPVS(ph)PPEGMTEPGHSR_
NCOR2 Phosphorylation S2258 -0.573 -0.210 _S(ph)PGNTSQPPAFFSK_
NCOR2 Phosphorylation S2413 0.973 _AKS(ph)PAPGLASGDRPPSVSSVHSEGDCNR_
PARP1 Phosphorylation S41 -0.803 _MAIMVQS(ph)PMFDGK_
PARP1 Ubiquitylation K84 1.223 _WDDQQK(gl)VK_
PARP1 Ubiquitylation K86 1.058 _VK(gl)KTAEAGGVTGK_
PARP1 Ubiquitylation K87 1.058 _VK(gl)KTAEAGGVTGK_
PARP1 Ubiquitylation K97 1.386 0.406 _TAEAGGVTGK(gl)GQDGIGSK_
PARP1 Ubiquitylation K105 0.828 _GQDGIGSK(gl)AEK_
PARP1 Ubiquitylation K108 1.317 _GQDGIGSKAEK(gl)_
PARP1 Ubiquitylation K119 1.569 _TLGDFAAEYAK(gl)SNR_
PARP1 Ubiquitylation K131 1.025 1.620 _GCMEK(gl)IEK_
PARP1 Ubiquitylation K197 0.445 1.157 _K(gl)QLPGVK_
PARP1 Ubiquitylation K254 0.589 _AQNDLIWNIKDELKK(gl)_
PARP1 Ubiquitylation K262 0.456 _VCSTNDLK(gl)ELLIFNK_
PARP1 Ubiquitylation K320 1.464 1.034 _SDAYYCTGDVTAWTK(gl)CMVK_
PARP1 Ubiquitylation K331 -0.425 -0.480 _TQTPNRK(gl)EWVTPK_
PARP1 Ubiquitylation K337 0.462 0.332 _EWVTPK(gl)EFR_
PARP1 Ubiquitylation K346 0.370 0.411 _EISYLK(gl)K_
PARP1 Phosphorylation T368 -1.474 -1.410 _IFPPETSASVAAT(ph)PPPSTASAPAAVNSSASADKPLSNM(ox)K_
PARP1 Ubiquitylation K400 0.844 1.095 _ILTLGK(gl)LSR_
PARP1 Ubiquitylation K414 1.227 1.241 _AMIEK(gl)LGGK_
PARP1 Ubiquitylation K418 1.131 _LGGK(gl)LTGTANK_
PARP1 Ubiquitylation K425 0.912 0.815 _LTGTANK(gl)ASLCISTKK_
PARP1 Ubiquitylation K433 0.942 _ASLCISTK(gl)K_
PARP1 Ubiquitylation K434 0.020 _ASLCISTKK(gl)_
PARP1 Ubiquitylation K447 1.480 _MEEVK(gl)EANIR_
PARP1 Ubiquitylation K518 0.108 _GQVKEEGINK(gl)SEK_
PARP1 Ubiquitylation K521 0.630 _GQVKEEGINKSEK(gl)R_
PARP1 Ubiquitylation K548 0.125 -0.480 _GGAAVDPDSGLEHSAHVLEK(gl)GGK_
PARP1 Ubiquitylation K551 0.492 -0.573 _GGAAVDPDSGLEHSAHVLEKGGK(gl)_
PARP1 Ubiquitylation K629 1.632 _TGNAWHSK(gl)NFTK_
PARP1 Ubiquitylation K633 0.964 0.091 _NFTK(gl)YPK_
PARP1 Ubiquitylation K654 -0.086 _K(gl)LTVNPGTK_
PARP1 Ubiquitylation K662 0.112 _LTVNPGTK(gl)SK_
PARP1 Ubiquitylation K664 -0.042 -0.111 _LTVNPGTKSK(gl)_
PARP1 Ubiquitylation K683 0.983 1.355 _MIFDVESM(ox)K(gl)K_
PARP1 Ubiquitylation K684 1.213 1.355 _MIFDVESMKK(gl)_
PARP1 Ubiquitylation K700 0.448 _MPLGK(gl)LSK_
PARP1 Phosphorylation S782 0.648 0.490 _GGS(ph)DDSSKDPIDVNYEK_
PARP1 Ubiquitylation K949 0.738 _HSVK(gl)GLGK_
RB1 Phosphorylation S69 -3.602 -3.397 _TAATAAAAAAEPPAPPPPPPPEEDPEQDS(ph)GPEDLPLVR_
RB1 Ubiquitylation K97 -0.546 _LK(gl)IPDHVR_
RB1 Phosphorylation T388 0.005 0.116 _TLQTDSIDSFETQRT(ph)PR_
RB1 Phosphorylation T405 -0.851 -0.901 _KSNLDEEVNVIPPHT(ph)PVR_
RB1 Phosphorylation S820 -0.019 _S(ph)PYKFPSSPLR_
RB1 Ubiquitylation K823 -2.214 _SPYK(gl)FPSSPLR_
RB1 Phosphorylation S827 0.824 0.111 _FPSS(ph)PLR_
RB1 Phosphorylation S839 -0.701 -1.045 _IPGGNIYIS(ph)PLKS(ph)PYK_
RB1 Ubiquitylation K842 -0.751 _IPGGNIYISPLK(gl)SPYK_
RB1 Phosphorylation S843 -0.701 -0.022 _IPGGNIYIS(ph)PLKS(ph)PYK_
RB1 Ubiquitylation K846 -2.084 _SPYK(gl)ISEGLPTPTK_
RB1 Phosphorylation T853 0.039 -0.555 _ISEGLPT(ph)PTKM(ox)T(ph)PR_
RB1 Ubiquitylation K856 -1.350 _ISEGLPTPTK(gl)MTPR_
RB1 Phosphorylation T858 -0.782 0.564 _ISEGLPT(ph)PTKMT(ph)PR_
RB1 Ubiquitylation K879 -0.187 _FQK(gl)INQMVCNSDR_
RBBP8 Phosphorylation S327 -0.154 0.038 _VSS(ph)PVFGATSSIK_
RUNX2 Phosphorylation S96 0.504 -0.399 _RFS(ph)PPSSSLQPGK_
RUNX2 Ubiquitylation K244 0.258 _NASAVMK(gl)NQVAR_
SPEN Phosphorylation S623 2.452 1.372 _RAS(ph)YDYNQDR_
SPEN Phosphorylation S727 0.569 0.583 _SQS(ph)PVHLR_
SPEN Phosphorylation S736 -1.190 -0.481 _RPQS(ph)PGAS(ph)PSQAER_
SPEN Phosphorylation S740 -0.446 _RPQS(ph)PGAS(ph)PSQAER_
SPEN Phosphorylation T1059 0.478 0.374 _LNT(ph)VASPKDCQELASISVGSGSRPSSDLQAR_
SPEN Phosphorylation S1062 0.195 0.089 _LNTVAS(ph)PKDCQELASISVGSGSRPSSDLQAR_
SPEN Phosphorylation T1140 0.280 -0.193 _NYCSLRDET(ph)PERK_
SPEN Phosphorylation S1194 0.847 0.567 _FGS(ph)PKKDVDEYER_
SPEN Phosphorylation S1222 -0.507 -0.636 _SLVHEVGKPPQDVTDDS(ph)PPSK_
SPEN Phosphorylation S1268 0.027 0.553 _HGS(ph)FHEDEDPIGSPR_
SPEN Phosphorylation S1278 -0.017 -0.642 _HGSFHEDEDPIGS(ph)PR_
SPEN Phosphorylation S1287 0.636 0.812 _LLSVKGS(ph)PK_
SPEN Phosphorylation T1619 -0.114 -0.035 _EVEKQEDTENHPKT(ph)PESAPENK_
SPEN Ubiquitylation K1661 0.811 _TTGDK(gl)TVEAPLVTEEK_
SPEN Phosphorylation S1797 0.049 _AEAAPES(ph)QPPASEDLEVDPPVAAK_
SPEN Phosphorylation T1826 0.121 -0.031 _SKT(ph)PVQAAAVSIVEKPVTR_
SPEN Phosphorylation S1918 -0.859 -0.612 _SVYATMGDHENRS(ph)PVKEPVEQPR_
SPEN Phosphorylation S2101 0.491 0.415 _NVDAAVS(ph)PR_
SPEN Phosphorylation S2114 -0.434 _ES(ph)GVVAVSPEKSES(ph)PQKEDGLSSQLK_
SPEN Phosphorylation S2120 0.189 0.279 _ESGVVAVS(ph)PEKS(ph)ESPQKEDGLSSQLK_
SPEN Phosphorylation S2124 0.055 0.177 _ESGVVAVS(ph)PEKS(ph)ESPQKEDGLSSQLK_
SPEN Phosphorylation S2126 0.762 0.625 _SES(ph)PQKEDGLSSQLK_
SPEN Phosphorylation S2156 -0.898 _SDPVDPDKEPEKEDVSAS(ph)GPSPEATQLAK_
SPEN Phosphorylation S2159 -1.078 -0.906 _SDPVDPDKEPEKEDVSASGPS(ph)PEATQLAK_
SPEN Phosphorylation S2359 -0.781 _KVVAPVESHVPES(ph)NQAQGESPAANEGTTVQHPEAPQEEK_
SPEN Phosphorylation S2366 -1.191 _KVVAPVESHVPESNQAQGES(ph)PAANEGTTVQHPEAPQEEK_
SPEN Phosphorylation S2411 2.394 _IPSTENS(ph)SQEISVEER_
SPEN Phosphorylation S2412 -0.493 _IPSTENSS(ph)QEISVEER_
SPEN Phosphorylation T2421 -0.518 -1.005 _IPSTENSSQEISVEERT(ph)PTK_
SPEN Phosphorylation T2460 -1.260 _VHSIIESDPVT(ph)PPSDPSIPIPTLPSVTAAK_
SPEN Phosphorylation S2493 -0.826 -0.552 _LSPPVASGGIPHQS(ph)PPTK_
STAT3 Ubiquitylation K177 0.957 _VVENLQDDFDFNYK(gl)TLK_
STAT3 Ubiquitylation K180 1.179 _TLK(gl)SQGDMQDLNGNNQSVTR_
STAT3 Ubiquitylation K244 0.262 _TLTDEELADWK(gl)R_
STAT3 Phosphorylation T714 -0.338 _FICVT(ph)PTTCSNTIDLPMS(ph)PR_
STAT3 Phosphorylation S727 -0.079 0.156 _FICVTPTTCSNTIDLPMS(ph)PR_
TCF3 Phosphorylation S328 0.865 0.756 _AGAPGALS(ph)PSYDGGLHGLQSK_
TLE1 Phosphorylation S286 0.242 0.160 _DASSS(ph)PASTASSASSTSLK_
TWIST1 Ubiquitylation K150 -0.176 _IQTLK(gl)LAAR_
YY1 Phosphorylation S247 0.269 0.058 _DIDHETVVEEQIIGENS(ph)PPDYSEYMTGK_
YY1 Ubiquitylation K301 0.655 0.006 _TIACPHK(gl)GCTK_
YY1 Ubiquitylation K339 0.205 _AFVESSK(gl)LKR_


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