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Query: ARNT

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARNT 0 -1.369 1.120 -0.500

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARNT Phosphorylation S81 1.133 _FARS(ph)DDEQSSADKER_
ARNT Ubiquitylation K421 -2.502 _DSFQQVVK(gl)LK_

Background Information for ARNT:


Pubmed-ARNT »
Uniprot-ARNT »
Biogrid-ARNT »
ProteomicsDB-ARNT »

Tumorportal-ARNT »
COSMIC-ARNT »
GenomeRNAi-ARNT »
Genecards-ARNT


Protein-protein Interactions for ARNT
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HIF1A Cat. description Hein, Mann, Cell 2015
Category members IP bait ARNT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCAT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C1QTNF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NARFL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPAS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SHMT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLX1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ARNT
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PAS_fold_3 IPR013655 0.69
Category members bHLH_dom IPR011598 0.32
Category members PAS_fold IPR013767 0.27
Category members PAC IPR001610 0.23
Category members PAS IPR000014 0.23
Category members Nuc_translocat IPR001067 0.04


Protein complexes (CORUM database) featuring ARNT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 4043 NEMO-HIF2(alpha)-ARNT complex Database 0.1
Category members Corum 1211 Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) Database 0.05
Category members Corum 5382 ARNT-HIF1A complex Database 0.04
Category members Corum 2152 ARNT-HLF complex Database 0


Categories featuring ARNT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0030522 intracellular receptor signaling pathway Database 0.9
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0033235 positive regulation of protein sumoylation Database 0.61
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_753 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 0 0.35
Category members GO Category GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia Database 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0045648 positive regulation of erythrocyte differentiation Database 0.23
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members Pathway Pathway_1145 BIOCARTA_EPONFKB_PATHWAY 0 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0042789 mRNA transcription from RNA polymerase II promoter Database 0.07
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress Database 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members GO Category GO:0000989 transcription factor binding transcription factor activity Database 0.01
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_407 BIOCARTA_HIF_PATHWAY 0 0
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001892 embryonic placenta development Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0010575 positive regulation vascular endothelial growth factor production Database 0
Category members GO Category GO:0017162 aryl hydrocarbon receptor binding Database 0
Category members GO Category GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0045821 positive regulation of glycolysis Database 0
Category members GO Category GO:0046886 positive regulation of hormone biosynthetic process Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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