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bioLOGIC Data

Query: SPEN

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
SPEN	2	5.449	0.970	-0.180				-0.126	-0.082

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
SPEN	Phosphorylation	S2411		2.394	_IPSTENS(ph)SQEISVEER_
SPEN	Phosphorylation	S623	2.452	1.372	_RAS(ph)YDYNQDR_
SPEN	Phosphorylation	S1287	0.636	0.812	_LLSVKGS(ph)PK_
SPEN	Phosphorylation	S2126	0.762	0.625	_SES(ph)PQKEDGLSSQLK_
SPEN	Phosphorylation	S727	0.569	0.583	_SQS(ph)PVHLR_
SPEN	Phosphorylation	S1194	0.847	0.567	_FGS(ph)PKKDVDEYER_
SPEN	Phosphorylation	S1268	0.027	0.553	_HGS(ph)FHEDEDPIGSPR_
SPEN	Phosphorylation	S2101	0.491	0.415	_NVDAAVS(ph)PR_
SPEN	Phosphorylation	T1059	0.478	0.374	_LNT(ph)VASPKDCQELASISVGSGSRPSSDLQAR_
SPEN	Phosphorylation	S2120	0.189	0.279	_ESGVVAVS(ph)PEKS(ph)ESPQKEDGLSSQLK_
SPEN	Phosphorylation	S2124	0.055	0.177	_ESGVVAVS(ph)PEKS(ph)ESPQKEDGLSSQLK_
SPEN	Phosphorylation	S1062	0.195	0.089	_LNTVAS(ph)PKDCQELASISVGSGSRPSSDLQAR_
SPEN	Phosphorylation	S1797		0.049	_AEAAPES(ph)QPPASEDLEVDPPVAAK_
SPEN	Phosphorylation	T1826	0.121	-0.031	_SKT(ph)PVQAAAVSIVEKPVTR_
SPEN	Phosphorylation	T1619	-0.114	-0.035	_EVEKQEDTENHPKT(ph)PESAPENK_
SPEN	Phosphorylation	T1140	0.280	-0.193	_NYCSLRDET(ph)PERK_
SPEN	Phosphorylation	S2114		-0.434	_ES(ph)GVVAVSPEKSES(ph)PQKEDGLSSQLK_
SPEN	Phosphorylation	S740		-0.446	_RPQS(ph)PGAS(ph)PSQAER_
SPEN	Phosphorylation	S736	-1.190	-0.481	_RPQS(ph)PGAS(ph)PSQAER_
SPEN	Phosphorylation	S2412		-0.493	_IPSTENSS(ph)QEISVEER_
SPEN	Phosphorylation	S2493	-0.826	-0.552	_LSPPVASGGIPHQS(ph)PPTK_
SPEN	Phosphorylation	S1918	-0.859	-0.612	_SVYATMGDHENRS(ph)PVKEPVEQPR_
SPEN	Phosphorylation	S1222	-0.507	-0.636	_SLVHEVGKPPQDVTDDS(ph)PPSK_
SPEN	Phosphorylation	S1278	-0.017	-0.642	_HGSFHEDEDPIGS(ph)PR_
SPEN	Phosphorylation	S2159	-1.078	-0.906	_SDPVDPDKEPEKEDVSASGPS(ph)PEATQLAK_
SPEN	Phosphorylation	T2421	-0.518	-1.005	_IPSTENSSQEISVEERT(ph)PTK_
SPEN	Phosphorylation	S2366		-1.191	_KVVAPVESHVPESNQAQGES(ph)PAANEGTTVQHPEAPQEEK_
SPEN	Ubiquitylation	K1661	0.811		_TTGDK(gl)TVEAPLVTEEK_
SPEN	Phosphorylation	S2156	-0.898		_SDPVDPDKEPEKEDVSAS(ph)GPSPEATQLAK_
SPEN	Phosphorylation	S2359	-0.781		_KVVAPVESHVPES(ph)NQAQGESPAANEGTTVQHPEAPQEEK_
SPEN	Phosphorylation	T2460	-1.260		_VHSIIESDPVT(ph)PPSDPSIPIPTLPSVTAAK_

Background Information for SPEN:

Pubmed-SPEN »

Uniprot-SPEN »

Biogrid-SPEN »

ProteomicsDB-SPEN »

Tumorportal-SPEN »

COSMIC-SPEN »

GenomeRNAi-SPEN »

Genecards-SPEN

Protein-protein Interactions for SPEN

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait BCLAF1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait FERMT3	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait SRSF1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait CAMKV	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait CCNC	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PIP4K2A	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RBPJ	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait TRIML2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait WRAP73	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in SPEN

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	RRM_dom	IPR000504	4.34
Category members	SPOC_C	IPR012921	1.41
Category members	SPOC_like_C_dom	IPR016194	0.9
Category members	SPOC_met	IPR010912	0.52

Protein complexes (CORUM database) featuring SPEN

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	351	Spliceosome	Database	9.3
Category members	Corum	2908	RBP-Jkappa-SHARP complex	Database	0.24
Category members	Corum	2930	SHARP-CtIP-RBP-Jkappa complex	Database	0.24
Category members	Corum	2921	SHARP-CtBP complex	Database	0.08
Category members	Corum	2931	SHARP-CtBP1-CtIP-RBP-Jkappa corepressor complex	Database	0.04
Category members	Corum	2923	SHARP-CtBP1-CtIP complex	Database	0

Categories featuring SPEN

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0003723	RNA binding	Database	INF
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0019048	modulation by virus of host morphology or physiology	Database	7.81
Category members	GO Category	GO:0000166	nucleotide binding	Database	5.91
Category members	GO Category	GO:0003697	single-stranded DNA binding	Database	4.24
Category members	GO Category	GO:0045892	negative regulation of transcription, DNA-dependent	Database	1.15
Category members	Human mutations	Broad_cancer_genes	Broad cancer genes (Lawrence et al., 2014)	literature	1.14
Category members	GO Category	GO:0003676	nucleic acid binding	Database	0.83
Category members	GO Category	GO:0003700	sequence-specific DNA binding transcription factor activity	Database	0.63
Category members	Pathway	Pathway_849	PID_NOTCH_PATHWAY	0	0.29
Category members	GO Category	GO:0017053	transcriptional repressor complex	Database	0.28
Category members	GO Category	GO:0045893	positive regulation of transcription, DNA-dependent	Database	0.28
Category members	GO Category	GO:0050769	positive regulation of neurogenesis	Database	0.06
Category members	GO Category	GO:0007219	Notch signaling pathway	Database	0.05
Category members	GO Category	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Database	0.02
Category members	Pathway	Pathway_119	PID_HES_HEY_PATHWAY	0	0
Category members	Pathway	Pathway_365	BIOCARTA_CARM_ER_PATHWAY	0	0
Category members	GO Category	GO:0001085	RNA polymerase II transcription factor binding	Database	0
Category members	GO Category	GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	Database	0
Category members	GO Category	GO:0003714	transcription corepressor activity	Database	0