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BIOCARTA_CARM_ER_PATHWAY
(Pathway_365)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
POLR2A 3 -0.397 0.863 1.593 -2.121 0.465
BRCA1 2 0.200 -0.140 0.433 0.018 0.146
SPEN 2 0.970 -0.180 -0.126 -0.082
PELP1 2 -0.603 -0.181
PELP1 2 -0.689 -1.064 0.487
PELP1 2
ERCC3 2 -1.110 1.490 2.619 2.418 0.499
HDAC9 1 -1.710 3.420
CCND1 1 -1.820 3.470
HDAC1 1 -1.980 4.450
HDAC1 1 -1.980 4.450 -0.122 0.307 0.969 0.094 0.191
MED1 1 0.780 -0.520 -1.530 -0.219
NCOR2 1 1.850 -1.050
NCOR2 1 1.850 -1.050 0.037 -1.127
HDAC2 1 -2.390 4.970
HDAC2 1 -2.390 4.970 0.187 -0.007 0.825
CREBBP 0 0.840 -0.950 -3.889 -1.071
HDAC7 0 -0.840 1.260
HDAC4 0 1.730 -0.740
MEF2C 0 -0.980 1.550
MEF2C 0 -0.980 1.550
EP300 0 -1.210 1.320 -1.089 -1.694 -0.723
HDAC5 0 -0.830 1.270
TBP 0 1.610 -1.170 -0.831
GTF2F1 0 -0.280 0.230 -3.106 1.494 -0.308
CARM1 0 -0.160 0.540 -0.032
GTF2E1 0 -0.370 0.610 -0.580
GRIP1 0 -0.360 0.430
HDAC11 0 -1.480 2.420
HDAC11 0 -1.480 2.420
HDAC3 0 -0.790 1.070
SRA1 0

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
BRCA1 Phosphorylation S123 0.465 0.445 _KENNSPEHLKDEVS(ph)IIQSM(ox)GYR_
BRCA1 Phosphorylation S753 2.662 4.077 _VSNNAEDPKDLMLS(ph)GER_
BRCA1 Phosphorylation S1009 0.733 1.028 _KNLLEENFEEHSM(ox)S(ph)PER_
BRCA1 Phosphorylation S1546 1.821 2.105 _NYPS(ph)QEELIK_
BRCA1 Phosphorylation S1564 3.065 _VVDVEEQQLEES(ph)GPHDLTETSYLPR_
BRCA1 Phosphorylation S1664 1.120 _EKPELTAS(ph)TER_
CCND1 Ubiquitylation K33 -0.490 _AMLK(gl)AEETCAPSVSYFK_
CCND1 Ubiquitylation K46 -1.016 -0.036 _AEETCAPSVSYFK(gl)CVQK_
CCND1 Ubiquitylation K95 -0.733 -0.137 _FLSLEPVK(gl)K_
CCND1 Ubiquitylation K96 -0.846 -0.155 _FLSLEPVKK(gl)_
CCND1 Ubiquitylation K238 0.245 _VIK(gl)CDPDCLR_
CREBBP Phosphorylation S2093 0.037 0.097 _SIS(ph)PSALQDLLR_
EP300 Phosphorylation S1038 -0.672 -0.349 _TEIKEEEDQPSTSATQSS(ph)PAPGQSK_
EP300 Phosphorylation S1726 0.994 0.627 _LGLGLDDESNNQQAAATQS(ph)PGDSRR_
EP300 Phosphorylation S2328 -1.092 0.725 _PQSQPPHSSPS(ph)PR_
GRIP1 Phosphorylation S43 0.361 0.201 _RQS(ph)IPEEFK_
GRIP1 Phosphorylation S847 0.159 0.098 _GSLS(ph)PVTKPR_
GTF2F1 Phosphorylation S385 0.043 0.017 _GNS(ph)RPGT(ph)PSAEGGSTSSTLR_
GTF2F1 Phosphorylation T389 0.484 -0.150 _GNS(ph)RPGT(ph)PSAEGGSTSSTLR_
GTF2F1 Phosphorylation S391 -0.032 -0.039 _GNS(ph)RPGTPS(ph)AEGGSTSSTLR_
GTF2F1 Phosphorylation S433 -0.395 -0.554 _LDTGPQSLS(ph)GK_
GTF2F1 Phosphorylation T445 0.385 0.574 _T(ph)TPNSGDVQVTEDAVR_
GTF2F1 Phosphorylation T446 0.385 0.574 _T(ph)TPNSGDVQVTEDAVR_
HDAC1 Ubiquitylation K50 0.036 _K(gl)MEIYRPHK_
HDAC1 Ubiquitylation K66 -0.593 _ANAEEMTK(gl)YHSDDYIK_
HDAC1 Ubiquitylation K74 0.620 -1.473 _YHSDDYIK(gl)FLR_
HDAC1 Ubiquitylation K89 0.749 -0.241 _SIRPDNMSEYSK(gl)QMQR_
HDAC1 Phosphorylation S393 -1.133 -1.144 _M(ox)LPHAPGVQM(ox)QAIPEDAIPEES(ph)GDEDEDDPDKR_
HDAC1 Phosphorylation S409 1.326 1.144 _ISICS(ph)SDKR_
HDAC1 Phosphorylation S410 1.326 1.144 _ISICS(ph)SDKR_
HDAC1 Ubiquitylation K412 0.642 -0.744 _ISICSSDK(gl)R_
HDAC11 Ubiquitylation K50 1.042 _VINFLK(gl)EEK_
HDAC11 Phosphorylation S121 -0.871 -0.105 _SPSS(ph)FCLSVWR_
HDAC2 Ubiquitylation K50 0.036 _K(gl)MEIYRPHK_
HDAC2 Ubiquitylation K67 -0.467 _ATAEEMTK(gl)YHSDEYIK_
HDAC2 Ubiquitylation K89 0.749 -0.241 _SIRPDNMSEYSK(gl)QMQR_
HDAC2 Ubiquitylation K284 0.749 _GHAK(gl)CVEVVK_
HDAC2 Phosphorylation S394 -0.865 -0.997 _M(ox)LPHAPGVQM(ox)QAIPEDAVHEDS(ph)GDEDGEDPDKR_
HDAC2 Phosphorylation S422 0.482 0.781 _IACDEEFS(ph)DSEDEGEGGR_
HDAC3 Phosphorylation S424 -0.354 _GPEENYSRPEAPNEFYDGDHDNDKES(ph)DVEI_
HDAC4 Phosphorylation S265 -0.390 _RS(ph)SPLLR_
HDAC4 Phosphorylation S266 -0.821 -0.598 _RSS(ph)PLLR_
HDAC4 Phosphorylation S632 -1.146 -0.837 _AQS(ph)SPASATFPVSVQEPPTKPR_
HDAC5 Phosphorylation S265 -0.390 _RS(ph)SPLLR_
HDAC5 Phosphorylation S266 -0.821 -0.598 _RSS(ph)PLLR_
HDAC7 Phosphorylation S181 -0.436 0.447 _KES(ph)APPSLR_
HDAC7 Phosphorylation S486 -0.969 -0.754 _AQS(ph)SPAAPASLSAPEPASQAR_
HDAC9 Phosphorylation S265 -0.390 _RS(ph)SPLLR_
HDAC9 Phosphorylation S266 -0.821 -0.598 _RSS(ph)PLLR_
MED1 Phosphorylation S664 3.368 _DNPAQDFSTLYGSS(ph)PLER_
MED1 Phosphorylation S771 -1.422 _LSS(ph)SDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLR_
MED1 Phosphorylation T1051 -1.201 -1.247 _SQT(ph)PPGVATPPIPK_
MED1 Phosphorylation T1057 -1.294 _SQT(ph)PPGVAT(ph)PPIPK_
MED1 Phosphorylation S1155 0.689 _NSSQSGGKPGS(ph)SPITK_
MED1 Phosphorylation S1156 0.829 1.055 _NSSQSGGKPGSS(ph)PITK_
MED1 Phosphorylation S1192 -0.792 _PSSLM(ox)NPSLSKPNIS(ph)PSHSRPPGGSDK_
MED1 Phosphorylation S1223 1.061 1.013 _AKS(ph)PISSGSGGSHM(ox)SGTSSSSGM(ox)K_
MED1 Phosphorylation S1433 -0.191 _NYGS(ph)PLISGSTPK_
MEF2C Ubiquitylation K23 -0.140 _QVTFTK(gl)R_
MEF2C Phosphorylation S240 0.008 0.302 _NS(ph)PGLLVSPGNLNK_
MEF2C Phosphorylation S406 0.272 0.338 _SEPVS(ph)PPRDR_
NCOR2 Phosphorylation S939 -0.637 _LLS(ph)PRPSLLTPTGDPR_
NCOR2 Phosphorylation S943 -0.740 _LLSPRPS(ph)LLTPTGDPR_
NCOR2 Phosphorylation S956 -0.223 -0.308 _ANAS(ph)PQKPLDLK_
NCOR2 Phosphorylation S1023 -0.334 _S(ph)RSPAPPADKEAFAAEAQK_
NCOR2 Phosphorylation S1025 1.950 _SRS(ph)PAPPADKEAFAAEAQK_
NCOR2 Phosphorylation T1383 -1.746 -2.157 _EGT(ph)PPPPPPSR_
NCOR2 Phosphorylation S1479 0.325 -0.132 _SLIGS(ph)PGR_
NCOR2 Phosphorylation S1778 -0.687 _HSSSPLS(ph)PGGPTHLTKPTTTSSSER_
NCOR2 Phosphorylation S1970 -0.321 _SGLEPAS(ph)SPSK_
NCOR2 Phosphorylation S1971 -0.480 _SGLEPASS(ph)PSK_
NCOR2 Phosphorylation S2223 -0.074 -1.140 _TSVLGGGEDGIEPVS(ph)PPEGMTEPGHSR_
NCOR2 Phosphorylation S2258 -0.573 -0.210 _S(ph)PGNTSQPPAFFSK_
NCOR2 Phosphorylation S2413 0.973 _AKS(ph)PAPGLASGDRPPSVSSVHSEGDCNR_
PELP1 Ubiquitylation K153 0.515 _LSSIK(gl)TR_
PELP1 Phosphorylation S625 -0.285 -0.371 _GS(ph)PDGSLQTGKPSAPK_
PELP1 Phosphorylation T889 -2.038 _AGSNEDPILAPSGT(ph)PPPTIPPDETFGGR_
PELP1 Phosphorylation S1177 2.415 1.885 _GADTAPTLAPEALPS(ph)QGEVER_
PELP1 Phosphorylation S1187 -1.852 _EGES(ph)PAAGPPPQELVEEEPSAPPTLLEEETEDGSDK_
POLR2A Ubiquitylation K32 1.006 _VQFGVLSPDELK(gl)R_
POLR2A Ubiquitylation K127 1.428 _IK(gl)DILAK_
POLR2A Ubiquitylation K132 0.487 _IKDILAK(gl)SK_
POLR2A Ubiquitylation K149 1.053 _LTHVYDLCK(gl)GK_
POLR2A Ubiquitylation K226 1.254 _VHEIFK(gl)R_
POLR2A Ubiquitylation K279 0.885 _NQDDLTHK(gl)LADIVK_
POLR2A Ubiquitylation K285 1.235 _LADIVK(gl)INNQLR_
POLR2A Ubiquitylation K417 0.662 _GNSQYPGAK(gl)YIIR_
POLR2A Ubiquitylation K707 1.333 _TYQDIQNTIK(gl)K_
POLR2A Ubiquitylation K710 1.362 1.417 _AK(gl)QDVIEVIEK_
POLR2A Ubiquitylation K751 -0.268 1.477 _DK(gl)TGSSAQK(gl)SLSEYNNFK_
POLR2A Ubiquitylation K758 -0.129 1.511 _DKTGSSAQK(gl)SLSEYNNFK_
POLR2A Ubiquitylation K767 1.702 _SLSEYNNFK(gl)SMVVSGAK_
POLR2A Ubiquitylation K775 1.252 _SMVVSGAK(gl)GSK_
POLR2A Ubiquitylation K812 -0.169 _TLPHFIK(gl)DDYGPESR_
POLR2A Ubiquitylation K976 0.145 0.332 _VIFPTGDSK(gl)VVLPCNLLR_
POLR2A Ubiquitylation K1014 0.766 _VVEGVK(gl)ELSK_
POLR2A Ubiquitylation K1125 4.356 1.173 _LK(gl)ELINISK_
POLR2A Ubiquitylation K1155 3.909 0.506 _AK(gl)DILCR_
POLR2A Ubiquitylation K1350 5.000 0.930 _VLSEK(gl)DVDPVR_
POLR2A Phosphorylation T1840 -1.940 _YT(ph)PTSPSYSPSSPEYTPTSPK_
POLR2A Phosphorylation T1842 -2.070 _YTPT(ph)SPSYS(ph)PSSPEYTPTSPK_
POLR2A Phosphorylation S1843 -1.841 -1.437 _YTPTS(ph)PSYSPSSPEYTPTSPK_
POLR2A Phosphorylation Y1846 -1.758 _YTPTSPSY(ph)SPSSPEYTPTS(ph)PK_
POLR2A Phosphorylation S1847 -1.016 -1.726 _Y(ph)TPTSPSYS(ph)PSSPEYTPT(ph)SPK_
POLR2A Phosphorylation S1849 -2.693 _YTPTSPSY(ph)SPS(ph)SPEYTPTSPK_
POLR2A Phosphorylation S1850 -1.360 -0.983 _YTPTSPSYSPSS(ph)PEYTPTS(ph)PK_
POLR2A Phosphorylation Y1853 -1.665 _YTPTSPSYSPSSPEY(ph)TPT(ph)SPK_
POLR2A Phosphorylation T1856 -1.740 _YTPTSPSYS(ph)PSSPEYTPT(ph)SPK_
POLR2A Phosphorylation S1857 -2.153 -2.282 _YTPTSPSYSPSSPEYTPTS(ph)PK_
POLR2A Phosphorylation T1877 -0.410 _YSPT(ph)SPTYS(ph)PTTPK_
POLR2A Phosphorylation S1878 -1.417 -0.623 _YSPTS(ph)PTYSPTT(ph)PK_
POLR2A Phosphorylation S1882 -0.491 0.086 _YSPTS(ph)PTYS(ph)PTTPK_
POLR2A Phosphorylation T1885 -0.372 -0.103 _YSPTS(ph)PTYSPTT(ph)PK_
POLR2A Phosphorylation S1889 -1.476 _YS(ph)PTSPTYSPTS(ph)PVYTPTSPK_
POLR2A Phosphorylation T1891 -3.041 -2.243 _YSPT(ph)SPTYSPTSPVYTPTSPK_
POLR2A Phosphorylation S1892 -2.675 -2.044 _YSPTS(ph)PTYSPTSPVYTPTSPK_
POLR2A Phosphorylation S1896 -1.174 _YSPTSPTYS(ph)PTSPVYTPT(ph)SPK_
POLR2A Phosphorylation T1898 -1.558 _YSPTS(ph)PTYSPT(ph)SPVYTPTSPK_
POLR2A Phosphorylation S1899 -0.903 -1.110 _YSPTSPTYSPTS(ph)PVYT(ph)PTSPK_
POLR2A Phosphorylation T1903 -0.180 -1.726 _YSPTSPTYSPTS(ph)PVYT(ph)PTSPK_
POLR2A Phosphorylation T1905 -1.328 -1.788 _YSPTSPTYSPTS(ph)PVYTPT(ph)SPK_
POLR2A Phosphorylation S1906 -2.720 -2.245 _YSPTS(ph)PTYSPTSPVYTPTS(ph)PK_
POLR2A Phosphorylation S1910 -1.108 -1.445 _YS(ph)PTSPTYS(ph)PTSPK_
POLR2A Phosphorylation T1912 -1.639 _YSPT(ph)SPTYS(ph)PTSPK_
POLR2A Phosphorylation S1913 -2.778 -1.508 _YSPTS(ph)PTYSPTS(ph)PK_
POLR2A Phosphorylation T1915 -2.612 _YSPTSPT(ph)YSPTSPK_
POLR2A Phosphorylation S1917 -2.286 -1.773 _YSPTS(ph)PTYS(ph)PTSPK_
POLR2A Phosphorylation T1919 -2.218 -1.471 _YSPTS(ph)PTYSPT(ph)SPK_
POLR2A Phosphorylation S1920 -1.088 -1.414 _YSPTS(ph)PTYSPTS(ph)PK_
SPEN Phosphorylation S623 2.452 1.372 _RAS(ph)YDYNQDR_
SPEN Phosphorylation S727 0.569 0.583 _SQS(ph)PVHLR_
SPEN Phosphorylation S736 -1.190 -0.481 _RPQS(ph)PGAS(ph)PSQAER_
SPEN Phosphorylation S740 -0.446 _RPQS(ph)PGAS(ph)PSQAER_
SPEN Phosphorylation T1059 0.478 0.374 _LNT(ph)VASPKDCQELASISVGSGSRPSSDLQAR_
SPEN Phosphorylation S1062 0.195 0.089 _LNTVAS(ph)PKDCQELASISVGSGSRPSSDLQAR_
SPEN Phosphorylation T1140 0.280 -0.193 _NYCSLRDET(ph)PERK_
SPEN Phosphorylation S1194 0.847 0.567 _FGS(ph)PKKDVDEYER_
SPEN Phosphorylation S1222 -0.507 -0.636 _SLVHEVGKPPQDVTDDS(ph)PPSK_
SPEN Phosphorylation S1268 0.027 0.553 _HGS(ph)FHEDEDPIGSPR_
SPEN Phosphorylation S1278 -0.017 -0.642 _HGSFHEDEDPIGS(ph)PR_
SPEN Phosphorylation S1287 0.636 0.812 _LLSVKGS(ph)PK_
SPEN Phosphorylation T1619 -0.114 -0.035 _EVEKQEDTENHPKT(ph)PESAPENK_
SPEN Ubiquitylation K1661 0.811 _TTGDK(gl)TVEAPLVTEEK_
SPEN Phosphorylation S1797 0.049 _AEAAPES(ph)QPPASEDLEVDPPVAAK_
SPEN Phosphorylation T1826 0.121 -0.031 _SKT(ph)PVQAAAVSIVEKPVTR_
SPEN Phosphorylation S1918 -0.859 -0.612 _SVYATMGDHENRS(ph)PVKEPVEQPR_
SPEN Phosphorylation S2101 0.491 0.415 _NVDAAVS(ph)PR_
SPEN Phosphorylation S2114 -0.434 _ES(ph)GVVAVSPEKSES(ph)PQKEDGLSSQLK_
SPEN Phosphorylation S2120 0.189 0.279 _ESGVVAVS(ph)PEKS(ph)ESPQKEDGLSSQLK_
SPEN Phosphorylation S2124 0.055 0.177 _ESGVVAVS(ph)PEKS(ph)ESPQKEDGLSSQLK_
SPEN Phosphorylation S2126 0.762 0.625 _SES(ph)PQKEDGLSSQLK_
SPEN Phosphorylation S2156 -0.898 _SDPVDPDKEPEKEDVSAS(ph)GPSPEATQLAK_
SPEN Phosphorylation S2159 -1.078 -0.906 _SDPVDPDKEPEKEDVSASGPS(ph)PEATQLAK_
SPEN Phosphorylation S2359 -0.781 _KVVAPVESHVPES(ph)NQAQGESPAANEGTTVQHPEAPQEEK_
SPEN Phosphorylation S2366 -1.191 _KVVAPVESHVPESNQAQGES(ph)PAANEGTTVQHPEAPQEEK_
SPEN Phosphorylation S2411 2.394 _IPSTENS(ph)SQEISVEER_
SPEN Phosphorylation S2412 -0.493 _IPSTENSS(ph)QEISVEER_
SPEN Phosphorylation T2421 -0.518 -1.005 _IPSTENSSQEISVEERT(ph)PTK_
SPEN Phosphorylation T2460 -1.260 _VHSIIESDPVT(ph)PPSDPSIPIPTLPSVTAAK_
SPEN Phosphorylation S2493 -0.826 -0.552 _LSPPVASGGIPHQS(ph)PPTK_
SRA1 Phosphorylation S69 -4.785 _VPASETS(ph)PGPPPMGPPPPSSK_
TBP Ubiquitylation K181 -0.140 -0.577 _LDLK(gl)TIALR_
TBP Ubiquitylation K225 -0.596 _MVCTGAK(gl)SEEQSR_


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