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Query: HDAC4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HDAC4 0 -1.211 1.730 -0.740

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HDAC4 Phosphorylation S265 -0.390 _RS(ph)SPLLR_
HDAC4 Phosphorylation S266 -0.821 -0.598 _RSS(ph)PLLR_
HDAC4 Phosphorylation S632 -1.146 -0.837 _AQS(ph)SPASATFPVSVQEPPTKPR_

Background Information for HDAC4:


Pubmed-HDAC4 »
Uniprot-HDAC4 »
Biogrid-HDAC4 »
ProteomicsDB-HDAC4 »

Tumorportal-HDAC4 »
COSMIC-HDAC4 »
GenomeRNAi-HDAC4 »
Genecards-HDAC4


Protein-protein Interactions for HDAC4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait YWHAH Cat. description Hein, Mann, Cell 2015


Protein Domains in HDAC4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members His_deacetylse IPR000286 0
Category members Histone_deAcase_II_euk IPR017320 0
Category members Arb2_domain IPR019154 0
Category members His_deacetylse_dom IPR023801 0
Category members Hist_deacetylase_Gln_rich_N IPR024643 0


Protein complexes (CORUM database) featuring HDAC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 55 HDAC4-ERK1 complex Database 0.29
Category members Corum 57 HDAC4-ERK2 complex Database 0.29
Category members Corum 1 BCL6-HDAC4 complex Database 0.13
Category members Corum 1620 G protein complex (HDAC4, GNB1, GNG2) Database 0


Categories featuring HDAC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_1254 PID_RANBP2_PATHWAY 0 1.33
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members GO Category GO:0042641 actomyosin Database 0.9
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0033235 positive regulation of protein sumoylation Database 0.61
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0070933 histone H4 deacetylation Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0030018 Z disc Database 0.32
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members GO Category GO:0014894 response to denervation involved in regulation of muscle adaptation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0002076 osteoblast development Database 0.13
Category members GO Category GO:0001047 core promoter binding Database 0.11
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members GO Category GO:0043393 regulation of protein binding Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0070555 response to interleukin-1 Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members GO Category GO:0000118 histone deacetylase complex Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0004407 histone deacetylase activity Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010832 negative regulation of myotube differentiation Database 0
Category members GO Category GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling Database 0
Category members GO Category GO:0014898 cardiac muscle hypertrophy in response to stress Database 0
Category members GO Category GO:0016575 histone deacetylation Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030955 potassium ion binding Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0031672 A band Database 0
Category members GO Category GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) Database 0
Category members GO Category GO:0033558 protein deacetylase activity Database 0
Category members GO Category GO:0033613 activating transcription factor binding Database 0
Category members GO Category GO:0034983 peptidyl-lysine deacetylation Database 0
Category members GO Category GO:0042113 B cell activation Database 0
Category members GO Category GO:0045820 negative regulation of glycolysis Database 0
Category members GO Category GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) Database 0
Category members GO Category GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) Database 0
Category members GO Category GO:0048742 regulation of skeletal muscle fiber development Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0051153 regulation of striated muscle cell differentiation Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0
Category members GO Category GO:0070932 histone H3 deacetylation Database 0


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