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Query: CCND1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CCND1 1 2.982 -1.820 3.470

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CCND1 Ubiquitylation K238 0.245 _VIK(gl)CDPDCLR_
CCND1 Ubiquitylation K46 -1.016 -0.036 _AEETCAPSVSYFK(gl)CVQK_
CCND1 Ubiquitylation K95 -0.733 -0.137 _FLSLEPVK(gl)K_
CCND1 Ubiquitylation K96 -0.846 -0.155 _FLSLEPVKK(gl)_
CCND1 Ubiquitylation K33 -0.490 _AMLK(gl)AEETCAPSVSYFK_

Background Information for CCND1:


Pubmed-CCND1 »
Uniprot-CCND1 »
Biogrid-CCND1 »
ProteomicsDB-CCND1 »

Tumorportal-CCND1 »
COSMIC-CCND1 »
GenomeRNAi-CCND1 »
Genecards-CCND1


Protein-protein Interactions for CCND1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCND1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015


Protein Domains in CCND1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cyclin_A/B/D/E/F IPR014400 0.09
Category members Cyclin_C-dom IPR004367 0
Category members Cyclin_N IPR006671 0
Category members Cyclin-like IPR013763 0


Protein complexes (CORUM database) featuring CCND1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 310 Cell cycle kinase complex CDC2 Database 0.52
Category members Corum 3084 CCND1-CDK4 complex Database 0.09
Category members Corum 5287 CDK4-CCND1 complex Database 0.09
Category members Corum 312 Cell cycle kinase complex CDK4 Database 0.06
Category members Corum 1633 CyclinD1-CDK4-CDK6 complex Database 0
Category members Corum 2635 BETA2-Cyclin D1 complex Database 0
Category members Corum 3087 CCND1-CDK6 complex Database 0
Category members Corum 311 Cell cycle kinase complex CDK2 Database 0
Category members Corum 313 Cell cycle kinase complex CDK5 Database 0


Categories featuring CCND1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members Pathway Pathway_636 PID_PI3K_PLC_TRK_PATHWAY 0 1.85
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0051301 cell division Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_628 BIOCARTA_GSK3_PATHWAY 0 0.6
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0010165 response to X-ray Database 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members Pathway Pathway_891 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 0 0.24
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_871 BIOCARTA_P53_PATHWAY 0 0.19
Category members GO Category GO:0000320 re-entry into mitotic cell cycle Database 0.17
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0032026 response to magnesium ion Database 0.15
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members GO Category GO:0048545 response to steroid hormone Database 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_1171 SA_REG_CASCADE_OF_CYCLIN_EXPR 0 0.1
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0033598 mammary gland epithelial cell proliferation Database 0.09
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members Pathway Pathway_113 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 0 0.08
Category members GO Category GO:0031571 mitotic G1 DNA damage checkpoint Database 0.08
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members GO Category GO:0045737 positive regulation of cyclin-dependent protein kinase activity Database 0.03
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0010243 response to organonitrogen compound Database 0.02
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members Disease phenotype B-cell_chronic_lymphocytic_leukemia B-cell chronic lymphocytic leukemia Database 0.01
Category members GO Category GO:0070141 response to UV-A Database 0.01
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1129 PID_P38_GAMMA_DELTA_PATHWAY 0 0
Category members Pathway Pathway_1164 SA_G1_AND_S_PHASES 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members Pathway Pathway_440 PID_FRA_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members Pathway Pathway_970 BIOCARTA_CELLCYCLE_PATHWAY 0 0
Category members Disease phenotype MANTLE_CELL_LYMPHOMA MANTLE CELL LYMPHOMA Database 0
Category members Disease phenotype MYELOMA_MULTIPLE MYELOMA MULTIPLE Database 0
Category members GO Category GO:0000307 cyclin-dependent protein kinase holoenzyme complex Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010039 response to iron ion Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0030857 negative regulation of epithelial cell differentiation Database 0
Category members GO Category GO:0033197 response to vitamin E Database 0
Category members GO Category GO:0033327 Leydig cell differentiation Database 0
Category members GO Category GO:0033601 positive regulation of mammary gland epithelial cell proliferation Database 0
Category members GO Category GO:0045444 fat cell differentiation Database 0
Category members GO Category GO:0051412 response to corticosterone Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0060749 mammary gland alveolus development Database 0
Category members GO Category GO:0071310 cellular response to organic substance Database 0


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