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KEGG_P53_SIGNALING_PATHWAY
(Pathway_382)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
DDB2 2 0.570 -0.690 -1.550 1.027
EI24 2 0.040 -0.170 1.100 0.629
CHEK1 2 -1.170 1.560
CHEK1 2 -1.170 1.560
CHEK2 2 0.530 0.100
RRM2B 1 -0.160 -0.120
CASP8 1 1.120 -1.090
TSC2 1 0.810 -0.710
TSC2 1 0.810 -0.710 -0.715
CCND1 1 -1.820 3.470
CCND2 1 1.210 -0.610
RRM2 1
ATR 1 -1.040 0.920 0.671 1.041 0.708
FAS 0 1.380 -1.070
FAS 0 1.380 -1.070
GTSE1 0 0.840 -0.390 1.016 0.270
SESN1 0 0.400 -0.270
BAX 0 1.590 -1.170 0.811 0.359
CCNE1 0 0.460 -0.980
CDK6 0 -0.190 0.160
CDK6 0 -0.190 0.160 -0.510 0.013
CCNG1 0 0.760 -0.640
STEAP3 0 1.380 -1.140 -0.558 -0.578
GADD45A 0 1.050 -0.170
TNFRSF10B 0 -0.030 -0.780
CDK2 0 -0.040 -0.300 -0.578 -0.797
CDK2 0 -0.040 -0.300 -0.202 -0.884 -0.107 -0.097 -0.501
CDKN1A 0 1.080 -0.750
SESN2 0 -0.060 -0.150
CCNB1 0 -0.410 -0.128 0.212 -0.166 -0.523
CDK4 0 1.930 -0.950
CDK4 0 1.930 -0.950 -0.510 0.013
MDM2 0 -0.210 0.080
TP53 0 -1.070 1.050 -2.808 0.076 -0.094 0.436 0.497
PMAIP1 0 0.570 -0.670
CDKN2A 0 -0.080 -0.260 -0.556 -1.080 -3.270 -1.110
ATM 0 0.398 0.474
CCNB2 0
RCHY1 0 -0.710 1.020
CASP3 0 0.570 -0.390
CDK1 0 -0.370 0.080 -0.202 -0.884 -0.107 -0.097 -0.501
PPM1D 0 -0.190 -0.110
CYCS 0 -0.020 -0.350 0.711 0.320
SFN 0 0.890 0.120 -4.300
SIAH1 0 1.220 -0.570
SERPINB5 0 0.480 -0.860 -2.992

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ATM Ubiquitylation K307 -0.196 _GAYESTK(gl)WR_
ATM Ubiquitylation K331 -0.126 _GK(gl)YSSGFR_
ATM Ubiquitylation K385 -0.669 _ESSDYSVPCK(gl)R_
ATM Ubiquitylation K1101 -0.548 _LFQDTK(gl)GDSSR_
ATM Ubiquitylation K1109 -1.666 _LLK(gl)ALPLK_
ATM Ubiquitylation K1698 -1.026 _DASYTK(gl)ALK_
ATM Ubiquitylation K1738 -0.137 _SAAVTCLK(gl)NILATK_
ATM Ubiquitylation K2025 -1.497 _SIGEPDSLYGCGGGK(gl)MLQPITR_
ATR Ubiquitylation K32 -0.929 _ELGSATPEEYNTVVQK(gl)PR_
ATR Phosphorylation S435 0.516 0.284 _RLS(ph)SSLNPSK_
ATR Ubiquitylation K746 -1.823 _NLK(gl)ATSQHECSSSQLK_
ATR Ubiquitylation K1019 1.662 _TLGK(gl)QLNVNRR_
ATR Ubiquitylation K1600 -0.437 _FQALK(gl)AEK_
ATR Ubiquitylation K2106 -0.136 _AYEWEK(gl)AGR_
ATR Ubiquitylation K2604 0.657 1.118 _LQGVIK(gl)TR_
BAX Ubiquitylation K57 -1.174 _MGGEAPELALDPVPQDASTK(gl)K_
BAX Ubiquitylation K58 -1.718 -1.174 _MGGEAPELALDPVPQDASTKK(gl)_
BAX Ubiquitylation K64 0.708 1.306 _LSECLK(gl)R_
CASP3 Ubiquitylation K11 -0.053 -0.687 _(ac)MENTENSVDSK(gl)SIK_
CASP3 Ubiquitylation K14 -0.455 -0.687 _SIK(gl)NLEPK_
CASP3 Ubiquitylation K57 -0.304 -1.817 _NFHK(gl)STGMTSR_
CASP3 Ubiquitylation K82 -0.268 -0.605 _NLK(gl)YEVR_
CASP8 Ubiquitylation K183 1.917 _IINDYEEFSK(gl)ER_
CASP8 Ubiquitylation K461 -2.031 _NMGK(gl)QMPQPTFTLR_
CCNB1 Ubiquitylation K18 -0.455 _AK(gl)INMAGAK_
CCNB1 Ubiquitylation K36 -1.833 -2.301 _VPTAPAATSK(gl)PGLRPR_
CCNB1 Ubiquitylation K59 -0.659 _VSEQLQAK(gl)MPMK_
CCNB1 Ubiquitylation K288 0.578 _QMEMK(gl)ILR_
CCNB2 Phosphorylation S92 -0.838 -0.676 _GPS(ph)PTPEDVSMKEENLCQAFSDALLCK_
CCND1 Ubiquitylation K33 -0.490 _AMLK(gl)AEETCAPSVSYFK_
CCND1 Ubiquitylation K46 -1.016 -0.036 _AEETCAPSVSYFK(gl)CVQK_
CCND1 Ubiquitylation K95 -0.733 -0.137 _FLSLEPVK(gl)K_
CCND1 Ubiquitylation K96 -0.846 -0.155 _FLSLEPVKK(gl)_
CCND1 Ubiquitylation K238 0.245 _VIK(gl)CDPDCLR_
CCND2 Ubiquitylation K45 -0.759 -0.277 _YLPQCSYFK(gl)CVQK_
CCND2 Ubiquitylation K49 -0.524 _CVQK(gl)DIQPYMR_
CCND2 Ubiquitylation K113 -0.572 _LK(gl)ETSPLTAEK_
CCND2 Ubiquitylation K173 -1.137 0.202 _EK(gl)LSLIR_
CCND2 Phosphorylation S269 0.049 _DGS(ph)KSEDELDQASTPTDVR_
CCND2 Phosphorylation S271 2.155 _DGSKS(ph)EDELDQASTPTDVR_
CCNE1 Phosphorylation S100 -0.765 _IIAPS(ph)RGSPLPVLSWANR_
CCNE1 Phosphorylation S103 -0.765 _IIAPS(ph)RGSPLPVLSWANR_
CCNE1 Phosphorylation S387 0.705 -0.922 _AS(ph)PLPSGLLTPPQSGK_
CCNG1 Ubiquitylation K187 0.399 _LEAQLK(gl)ACHCR_
CDK1 Ubiquitylation K6 0.011 -0.784 _(ac)M(ox)EDYTK(gl)IEK_
CDK1 Ubiquitylation K20 -0.327 -0.270 _IGEGTYGVVYK(gl)GR_
CDK1 Ubiquitylation K33 0.736 0.239 _TTGQVVAMK(gl)K_
CDK1 Ubiquitylation K34 -0.306 _TTGQVVAMKK(gl)_
CDK1 Ubiquitylation K58 0.312 -0.262 _EISLLK(gl)ELR_
CDK1 Ubiquitylation K136 -0.468 _DLK(gl)PQNLLIDDK(gl)GTIK_
CDK1 Ubiquitylation K145 0.161 -0.954 _DLKPQNLLIDDK(gl)GTIK_
CDK1 Ubiquitylation K149 -0.038 _GTIK(gl)LADFGLAR_
CDK1 Ubiquitylation K251 -0.047 -1.236 _WK(gl)PGSLASHVK_
CDK1 Ubiquitylation K280 0.179 -1.210 _MLIYDPAK(gl)R_
CDK2 Ubiquitylation K6 -0.130 -0.399 _(ac)MENFQK(gl)VEK_
CDK2 Ubiquitylation K6 0.011 -0.784 _(ac)M(ox)EDYTK(gl)IEK_
CDK2 Phosphorylation T14 0.429 _IGEGT(ph)YGVVYK_
CDK2 Phosphorylation Y15 0.697 0.743 _IGEGTY(ph)GVVYK_
CDK2 Ubiquitylation K20 0.272 _IGEGTYGVVYK(gl)AR_
CDK2 Ubiquitylation K20 -0.327 -0.270 _IGEGTYGVVYK(gl)GR_
CDK2 Ubiquitylation K24 0.366 _NK(gl)LTGEVVALKK_
CDK2 Ubiquitylation K33 0.033 _NKLTGEVVALK(gl)K_
CDK2 Ubiquitylation K33 0.736 0.239 _TTGQVVAMK(gl)K_
CDK2 Ubiquitylation K34 0.542 _LTGEVVALKK(gl)_
CDK2 Ubiquitylation K34 -0.306 _TTGQVVAMKK(gl)_
CDK2 Ubiquitylation K58 0.312 -0.262 _EISLLK(gl)ELR_
CDK2 Ubiquitylation K136 -0.468 _DLK(gl)PQNLLIDDK(gl)GTIK_
CDK2 Ubiquitylation K145 0.161 -0.954 _DLKPQNLLIDDK(gl)GTIK_
CDK2 Ubiquitylation K149 -0.038 _GTIK(gl)LADFGLAR_
CDK2 Ubiquitylation K251 -0.047 -1.236 _WK(gl)PGSLASHVK_
CDK2 Ubiquitylation K280 0.179 -1.210 _MLIYDPAK(gl)R_
CDK2 Ubiquitylation K298 -1.907 -2.380 _QDFSK(gl)VVPPLDEDGR_
CDK4 Ubiquitylation K142 -0.552 _DLK(gl)PENILVTSGGTVK_
CDK4 Ubiquitylation K211 -0.101 _K(gl)PLFCGNSEADQLGK_
CDK4 Phosphorylation S236 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK4 Phosphorylation S249 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK4 Ubiquitylation K297 0.247 0.052 _ALQHSYLHK(gl)DEGNPE_
CDK4 Phosphorylation S385 0.649 _HSSIS(ph)PVRLPLNSSLGAELSR_
CDK4 Phosphorylation S420 0.004 -0.202 _ES(ph)KGSPVFLPR_
CDK4 Phosphorylation S423 -0.155 -0.297 _GS(ph)PVFLPR_
CDK4 Phosphorylation T514 0.364 0.570 _DSKPIALKEEIVT(ph)PK_
CDK4 Phosphorylation S681 -2.532 -2.051 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK4 Phosphorylation S685 -2.729 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK4 Phosphorylation T692 -0.765 -1.849 _AIT(ph)PPQQPYK_
CDK4 Phosphorylation S1082 -1.661 -0.980 _KETTSGTSTEPVKNS(ph)SPAPPQPAPGK_
CDK4 Phosphorylation S1083 -1.093 -1.330 _NSS(ph)PAPPQPAPGK_
CDK4 Phosphorylation T1244 -0.956 _RT(ph)PTMPQEEAAACPPHILPPEK_
CDK6 Ubiquitylation K3 0.121 0.039 _(ac)MEK(gl)DGLCR_
CDK6 Phosphorylation S236 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK6 Phosphorylation S249 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK6 Phosphorylation S385 0.649 _HSSIS(ph)PVRLPLNSSLGAELSR_
CDK6 Phosphorylation S420 0.004 -0.202 _ES(ph)KGSPVFLPR_
CDK6 Phosphorylation S423 -0.155 -0.297 _GS(ph)PVFLPR_
CDK6 Phosphorylation T514 0.364 0.570 _DSKPIALKEEIVT(ph)PK_
CDK6 Phosphorylation S681 -2.532 -2.051 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK6 Phosphorylation S685 -2.729 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK6 Phosphorylation T692 -0.765 -1.849 _AIT(ph)PPQQPYK_
CDK6 Phosphorylation S1082 -1.661 -0.980 _KETTSGTSTEPVKNS(ph)SPAPPQPAPGK_
CDK6 Phosphorylation S1083 -1.093 -1.330 _NSS(ph)PAPPQPAPGK_
CDK6 Phosphorylation T1244 -0.956 _RT(ph)PTMPQEEAAACPPHILPPEK_
CDKN1A Ubiquitylation K188 -2.505 -1.077 _QTSMTDFYHSK(gl)R_
CHEK1 Ubiquitylation K53 0.879 _AVDCPENIK(gl)K_
CHEK1 Ubiquitylation K54 0.738 _AVDCPENIKK(gl)_
CHEK1 Phosphorylation S296 -0.098 0.184 _VTS(ph)GGVSESPSGFSK_
CHEK1 Phosphorylation S300 1.091 _VTSGGVS(ph)ESPSGFSK_
CHEK1 Phosphorylation S302 1.750 _VTSGGVSES(ph)PSGFSK_
CHEK1 Phosphorylation S317 1.903 _HIQSNLDFS(ph)PVNSASSEENVK_
CHEK1 Ubiquitylation K399 -0.582 _ETCEK(gl)LGYQWK_
CHEK2 Phosphorylation S260 3.670 3.632 _KFAIGS(ph)AR_
CHEK2 Ubiquitylation K437 -0.826 _TQVSLK(gl)DQITSGK_
CYCS Ubiquitylation K40 -2.265 _K(gl)TGQAPGYSYTAANK(gl)NK_
CYCS Ubiquitylation K54 -0.872 -1.922 _K(gl)TGQAPGYSYTAANK(gl)NK_
CYCS Ubiquitylation K56 -0.872 -1.922 _TGQAPGYSYTAANKNK(gl)_
CYCS Ubiquitylation K101 -1.859 _ADLIAYLKK(gl)_
DDB2 Phosphorylation S24 -1.622 -0.259 _S(ph)RSPLELEPEAK_
DDB2 Phosphorylation S26 -1.330 -0.351 _S(ph)PLELEPEAK_
DDB2 Ubiquitylation K151 0.781 _DKPTFIK(gl)GIGAGGSITGLK_
DDB2 Ubiquitylation K187 1.683 3.110 _LQDFK(gl)GNILR_
DDB2 Ubiquitylation K309 1.567 _LLTTDQK(gl)SEIR_
DDB2 Ubiquitylation K362 3.835 2.315 _YPDPNFK(gl)SCTPYELR_
EI24 Phosphorylation S46 1.497 0.314 _RAS(ph)SVLAQR_
EI24 Phosphorylation S330 3.730 2.164 _FPSPHPS(ph)PAK_
FAS Phosphorylation S236 -0.027 _ENQGS(ph)HESPTLNPETVAINLSDVDLSK_
FAS Phosphorylation S239 0.266 _ENQGSHES(ph)PTLNPETVAINLSDVDLSK_
FAS Ubiquitylation K343 1.126 _IQTIILK(gl)DITSDSENSNFR_
GADD45A Ubiquitylation K12 -0.515 0.281 _TLEEFSAGEQK(gl)TER_
GADD45A Ubiquitylation K29 0.092 _VGDALEEVLSK(gl)ALSQR_
GTSE1 Phosphorylation S168 -1.174 _LLASS(ph)PALPSSGAQAR_
GTSE1 Phosphorylation S243 -0.544 -0.645 _KEIPAS(ph)PSR_
GTSE1 Phosphorylation S477 -0.326 -0.430 _AQRPQS(ph)CTSVGR_
GTSE1 Phosphorylation T479 -0.221 _AQRPQSCT(ph)SVGR_
GTSE1 Phosphorylation S536 -1.250 -1.754 _AVGS(ph)PLCVPAR_
GTSE1 Phosphorylation S575 -0.557 -0.137 _LVDVS(ph)PDRGSPPSR_
GTSE1 Phosphorylation S580 -0.308 _LVDVS(ph)PDRGS(ph)PPSR_
GTSE1 Phosphorylation S592 0.112 0.100 _VPQALNFS(ph)PEESDSTFSK_
GTSE1 Phosphorylation S705 -0.288 -0.375 _NVAKPSPVVGQLIDLSSPLIQLS(ph)PEADKENVDSPLLK_
GTSE1 Phosphorylation S715 -0.326 _NVAKPSPVVGQLIDLSSPLIQLSPEADKENVDS(ph)PLLK_
MDM2 Phosphorylation S166 0.576 1.068 _AIS(ph)ETEENSDELSGER_
MDM2 Ubiquitylation K334 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K336 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K363 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K364 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K473 0.806 _NK(gl)PCPVCR_
PMAIP1 Ubiquitylation K35 -1.475 0.286 _RFGDK(gl)LNFR_
PMAIP1 Ubiquitylation K41 -1.597 0.340 _QK(gl)LLNLISK_
PMAIP1 Ubiquitylation K48 -2.007 -0.586 _LLNLISK(gl)_
PPM1D Phosphorylation S85 -1.520 _DPLPDAGAS(ph)PAPSR_
RCHY1 Ubiquitylation K135 0.341 _HK(gl)CIENVSR_
RRM2 Phosphorylation S80 -1.483 -1.780 _VPLAPITDPQQLQLS(ph)PLK_
RRM2 Phosphorylation T93 -1.284 -0.534 _GLSLVDKENT(ph)PPALSGTR_
RRM2 Ubiquitylation K106 -0.247 _VLASK(gl)TAR_
RRM2 Ubiquitylation K121 -2.427 -0.884 _TK(gl)AAAPGVEDEPLLR_
RRM2 Ubiquitylation K424 2.394 -0.588 _TNFFEK(gl)R_
RRM2B Ubiquitylation K424 2.394 -0.588 _TNFFEK(gl)R_
SESN1 Ubiquitylation K396 -0.281 _HFEDTSYGYK(gl)DFSR_
SESN2 Ubiquitylation K13 -0.079 _AELK(gl)DYLR_
SFN Ubiquitylation K11 0.561 0.388 _AK(gl)LAEQAER_
SFN Ubiquitylation K49 -0.093 0.337 _NLLSVAYK(gl)_
SIAH1 Ubiquitylation K31 -1.541 _QTATALPTGTSK(gl)CPPSQR_
STEAP3 Phosphorylation S17 1.039 _PEEMDKPLISLHLVDS(ph)DSSLAK_
STEAP3 Ubiquitylation K175 -0.783 -0.882 _QVPICGDQPEAK(gl)R_
STEAP3 Ubiquitylation K472 -0.323 _ESTIK(gl)FTLPTDHALAEK_
STEAP3 Ubiquitylation K484 -0.079 0.275 _FTLPTDHALAEK(gl)TSHV_
TNFRSF10B Ubiquitylation K369 -0.724 _KLGLMDNEIK(gl)VAK_
TP53 Ubiquitylation K120 -0.188 _LGFLHSGTAK(gl)SVTCTYSPALNK_
TP53 Ubiquitylation K164 0.157 -1.260 _AMAIYK(gl)QSQHMTEVVR_
TP53 Phosphorylation S314 -0.695 -1.000 _ALPNNTSS(ph)SPQPK_
TP53 Phosphorylation S315 -0.762 -0.959 _RALPNNTSSS(ph)PQPK_
TP53 Ubiquitylation K320 -0.978 _ALPNNTSSSPQPKK(gl)_
TP53 Ubiquitylation K357 -0.231 -0.823 _ELNEALELKDAQAGK(gl)EPGGSR_
TSC2 Ubiquitylation K3 -1.397 _(ac)AK(gl)PTSKDSGLK_
TSC2 Ubiquitylation K14 -1.297 _DSGLKEK(gl)FK_
TSC2 Ubiquitylation K69 0.051 _MIGQICEVAK(gl)TK_
TSC2 Ubiquitylation K71 -0.157 _MIGQICEVAKTK(gl)_
TSC2 Ubiquitylation K258 -0.278 _ELCEPCWK(gl)LMR_
TSC2 Ubiquitylation K634 1.610 _LGLPNK(gl)DGVVR_
TSC2 Phosphorylation S950 -0.152 -0.529 _STS(ph)LNERPK_
TSC2 Phosphorylation S1064 -0.927 _SLLGLDSGELQSGPESSSS(ph)PGVHVR_
TSC2 Phosphorylation S1248 -0.604 _SNTDSAVVMEEGS(ph)PGEVPVLVEPPGLEDVEAALGMDRR_
TSC2 Phosphorylation S1329 -0.120 _S(ph)SSSPELQTLQDILGDPGDK_
TSC2 Phosphorylation S1331 -0.262 _SSS(ph)SPELQTLQDILGDPGDKADVGR_
TSC2 Phosphorylation S1332 -0.063 _SSSS(ph)PELQTLQDILGDPGDK_
TSC2 Phosphorylation S1355 0.174 0.351 _ADVGRLS(ph)PEVK_
TSC2 Phosphorylation S1362 0.859 _S(ph)QSGTLDGESAAWSASGEDSR_
TSC2 Phosphorylation S1364 0.522 0.550 _SQS(ph)GTLDGESAAWSASGEDSR_
TSC2 Phosphorylation T1366 0.137 _SQSGT(ph)LDGESAAWSASGEDSR_
TSC2 Phosphorylation S1396 0.498 _S(ph)PSGLRPR_
TSC2 Phosphorylation S1743 0.596 _RLISS(ph)VEDFTEFV_


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