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Query: SIAH1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SIAH1 0 -1.541 1.220 -0.570

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SIAH1 Ubiquitylation K31 -1.541 _QTATALPTGTSK(gl)CPPSQR_

Background Information for SIAH1:


Pubmed-SIAH1 »
Uniprot-SIAH1 »
Biogrid-SIAH1 »
ProteomicsDB-SIAH1 »

Tumorportal-SIAH1 »
COSMIC-SIAH1 »
GenomeRNAi-SIAH1 »
Genecards-SIAH1


Protein-protein Interactions for SIAH1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EXOC3L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait JSRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRR20E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIAH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SIAH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_RING IPR001841 0
Category members TRAF-like IPR008974 0
Category members Znf_SIAH IPR013010 0
Category members 7-in-absentia-prot_TRAF-dom IPR018121 0


Protein complexes (CORUM database) featuring SIAH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1255 Ubiquitin E3 ligase (SIAH1, SIP, SKP1A, TBL1X) Database 0.1


Categories featuring SIAH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0030163 protein catabolic process Database 0.38
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0030877 beta-catenin destruction complex Database 0.31
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_692 REACTOME_NETRIN1_SIGNALING 0 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0031648 protein destabilization Database 0


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