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Query: DDB2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DDB2 2 4.833 0.570 -0.690 -1.550 1.027

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DDB2 Ubiquitylation K187 1.683 3.110 _LQDFK(gl)GNILR_
DDB2 Ubiquitylation K362 3.835 2.315 _YPDPNFK(gl)SCTPYELR_
DDB2 Ubiquitylation K309 1.567 _LLTTDQK(gl)SEIR_
DDB2 Phosphorylation S24 -1.622 -0.259 _S(ph)RSPLELEPEAK_
DDB2 Phosphorylation S26 -1.330 -0.351 _S(ph)PLELEPEAK_
DDB2 Ubiquitylation K151 0.781 _DKPTFIK(gl)GIGAGGSITGLK_

Background Information for DDB2:


Pubmed-DDB2 »
Uniprot-DDB2 »
Biogrid-DDB2 »
ProteomicsDB-DDB2 »

Tumorportal-DDB2 »
COSMIC-DDB2 »
GenomeRNAi-DDB2 »
Genecards-DDB2


Protein-protein Interactions for DDB2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait COPS7A Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4B Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait APEX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS7B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRYBA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTSE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PFDN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SAMD4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPATA6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSSCA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TIGD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DDB2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members Quinoprot_gluc/sorb_DH IPR011041 0


Protein complexes (CORUM database) featuring DDB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 726 DDB2 complex Database 1.33
Category members Corum 1162 Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) Database 0.91
Category members Corum 790 DDB complex Database 0.33


Categories featuring DDB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0009411 response to UV Database 0.79
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0006290 pyrimidine dimer repair Database 0.25
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0051865 protein autoubiquitination Database 0.18


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