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Query: CDK6

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDK6 0 0.836 -0.190 0.160
CDK6 0 0.836 -0.190 0.160 -0.510 0.013

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDK6 Phosphorylation S385 0.649 _HSSIS(ph)PVRLPLNSSLGAELSR_
CDK6 Phosphorylation T514 0.364 0.570 _DSKPIALKEEIVT(ph)PK_
CDK6 Phosphorylation S236 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK6 Phosphorylation S249 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK6 Ubiquitylation K3 0.121 0.039 _(ac)MEK(gl)DGLCR_
CDK6 Phosphorylation S420 0.004 -0.202 _ES(ph)KGSPVFLPR_
CDK6 Phosphorylation S423 -0.155 -0.297 _GS(ph)PVFLPR_
CDK6 Phosphorylation T1244 -0.956 _RT(ph)PTMPQEEAAACPPHILPPEK_
CDK6 Phosphorylation S1082 -1.661 -0.980 _KETTSGTSTEPVKNS(ph)SPAPPQPAPGK_
CDK6 Phosphorylation S1083 -1.093 -1.330 _NSS(ph)PAPPQPAPGK_
CDK6 Phosphorylation T692 -0.765 -1.849 _AIT(ph)PPQQPYK_
CDK6 Phosphorylation S681 -2.532 -2.051 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK6 Phosphorylation S685 -2.729 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_

Background Information for CDK6:


Pubmed-CDK6 »
Uniprot-CDK6 »
Biogrid-CDK6 »
ProteomicsDB-CDK6 »

Tumorportal-CDK6 »
COSMIC-CDK6 »
GenomeRNAi-CDK6 »
Genecards-CDK6


Protein-protein Interactions for CDK6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCND3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDKN2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM26E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCF2L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PAK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDK6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CDK6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1633 CyclinD1-CDK4-CDK6 complex Database 0
Category members Corum 3087 CCND1-CDK6 complex Database 0
Category members Corum 3088 CCND2-CDK6 complex Database 0
Category members Corum 3089 CCND3-CDK6 complex Database 0
Category members Corum 5100 CyclinD3-CDK4-CDK6 complex Database 0
Category members Corum 5101 CyclinD3-CDK4-CDK6-p21 complex Database 0


Categories featuring CDK6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0051301 cell division Database 1.15
Category members GO Category GO:0045786 negative regulation of cell cycle Database 0.93
Category members GO Category GO:0060218 hematopoietic stem cell differentiation Database 0.74
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0045638 negative regulation of myeloid cell differentiation Database 0.1
Category members GO Category GO:0003323 type B pancreatic cell development Database 0.1
Category members GO Category GO:0042063 gliogenesis Database 0.1
Category members GO Category GO:0004693 cyclin-dependent protein serine/threonine kinase activity Database 0.08
Category members GO Category GO:0021542 dentate gyrus development Database 0.06
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0048699 generation of neurons Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_970 BIOCARTA_CELLCYCLE_PATHWAY 0 0
Category members Disease phenotype Autosomal_recessive_primary_microcephaly Autosomal recessive primary microcephaly Database 0
Category members GO Category GO:0000307 cyclin-dependent protein kinase holoenzyme complex Database 0
Category members GO Category GO:0001954 positive regulation of cell-matrix adhesion Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0014002 astrocyte development Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0021670 lateral ventricle development Database 0
Category members GO Category GO:0030332 cyclin binding Database 0
Category members GO Category GO:0045596 negative regulation of cell differentiation Database 0
Category members GO Category GO:0045646 regulation of erythrocyte differentiation Database 0


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