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negative regulation of cell differentiation
(GO:0045596)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
JAG1 0 -0.260 0.070
CDK6 0 -0.190 0.160
CDK6 0 -0.190 0.160 -0.510 0.013
GLI3 0 -0.980 1.650
HES1 0 -0.940 0.860
TWIST1 0 -0.640 1.150
ITGB1 0 0.390 -0.650 0.101 -0.036
CTNNB1 0 0.490 -0.230
CTNNB1 0 0.490 -0.230 -0.415 0.628 0.215
RBPJ 0 1.900 -0.160 -0.367 0.284 0.723 -0.090 0.134
SIX2 0 1.040 -0.950 -0.334 0.495
SUZ12 0 -0.710 0.770 0.451 1.156
SUZ12 0 -0.710 0.770 -0.670 0.955 0.457
SOX2 0 -0.250 0.870
PRAME 0 -0.110 -0.120

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CDK6 Ubiquitylation K3 0.121 0.039 _(ac)MEK(gl)DGLCR_
CDK6 Phosphorylation S236 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK6 Phosphorylation S249 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK6 Phosphorylation S385 0.649 _HSSIS(ph)PVRLPLNSSLGAELSR_
CDK6 Phosphorylation S420 0.004 -0.202 _ES(ph)KGSPVFLPR_
CDK6 Phosphorylation S423 -0.155 -0.297 _GS(ph)PVFLPR_
CDK6 Phosphorylation T514 0.364 0.570 _DSKPIALKEEIVT(ph)PK_
CDK6 Phosphorylation S681 -2.532 -2.051 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK6 Phosphorylation S685 -2.729 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK6 Phosphorylation T692 -0.765 -1.849 _AIT(ph)PPQQPYK_
CDK6 Phosphorylation S1082 -1.661 -0.980 _KETTSGTSTEPVKNS(ph)SPAPPQPAPGK_
CDK6 Phosphorylation S1083 -1.093 -1.330 _NSS(ph)PAPPQPAPGK_
CDK6 Phosphorylation T1244 -0.956 _RT(ph)PTMPQEEAAACPPHILPPEK_
CTNNB1 Ubiquitylation K158 -1.265 _AIPELTK(gl)LLNDEDQVVVNK_
CTNNB1 Ubiquitylation K180 -0.546 -0.636 _AAVM(ox)VHQLSK(gl)K_
CTNNB1 Ubiquitylation K181 -0.717 -0.729 _AAVMVHQLSKK(gl)_
CTNNB1 Phosphorylation S191 -0.024 0.129 _S(ph)PQMVSAIVR_
CTNNB1 Ubiquitylation K435 -0.350 _NK(gl)MM(ox)VCQVGGIEALVR_
CTNNB1 Ubiquitylation K496 -1.262 _LHYGLPVVVK(gl)_
CTNNB1 Phosphorylation S552 1.233 1.224 _RTS(ph)MGGTQQQFVEGVR_
CTNNB1 Phosphorylation T556 1.275 0.995 _RTSM(ox)GGT(ph)QQQFVEGVR_
CTNNB1 Ubiquitylation K671 -0.941 -0.934 _MSEDKPQDYK(gl)K_
GLI3 Phosphorylation S664 -0.582 -0.252 _S(ph)PGRPTQGALGEQQDLSNTTSK_
HES1 Ubiquitylation K66 0.212 _TLILDALK(gl)K_
HES1 Ubiquitylation K67 0.212 _TLILDALK(gl)K_
HES1 Ubiquitylation K109 -0.891 _AQMTAALSTDPSVLGK(gl)YR_
ITGB1 Ubiquitylation K774 0.402 _MNAK(gl)WDTGENPIYK_
ITGB1 Ubiquitylation K784 -0.172 0.350 _WDTGENPIYK(gl)SAVTTVVNPK_
ITGB1 Ubiquitylation K794 0.755 0.604 _SAVTTVVNPK(gl)YEGK_
JAG1 Ubiquitylation K1142 -0.783 _HGANTVPIKDYENK(gl)_
PRAME Ubiquitylation K157 -2.418 _ASLYSFPEPEAAQPMTK(gl)K_
PRAME Ubiquitylation K158 -2.418 _ASLYSFPEPEAAQPMTK(gl)K_
SIX2 Ubiquitylation K53 0.475 _AK(gl)AVVAFHR_
SOX2 Phosphorylation S251 0.157 -0.109 _SEASSS(ph)PPVVTSSSHSR_
SUZ12 Ubiquitylation K341 -0.110 -0.960 _ATWETILDGK(gl)R_
SUZ12 Ubiquitylation K390 -0.696 _NSESLHQENK(gl)PGSVKPTQTIAVK_
SUZ12 Phosphorylation S546 0.533 0.248 _ASM(ox)SEFLES(ph)EDGEVEQQR_
SUZ12 Phosphorylation S583 -0.295 _LYFHSDTCLPLRPQEMEVDS(ph)EDEKDPEWLR_
TWIST1 Ubiquitylation K150 -0.176 _IQTLK(gl)LAAR_


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