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Query: JAG1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
JAG1 0 -0.713 -0.260 0.070

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
JAG1 Ubiquitylation K1142 -0.783 _HGANTVPIKDYENK(gl)_

Background Information for JAG1:


Pubmed-JAG1 »
Uniprot-JAG1 »
Biogrid-JAG1 »
ProteomicsDB-JAG1 »

Tumorportal-JAG1 »
COSMIC-JAG1 »
GenomeRNAi-JAG1 »
Genecards-JAG1


Protein-protein Interactions for JAG1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in JAG1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members EGF-like_Ca-bd_dom IPR001881 0.69
Category members EGF_extracell IPR013111 0.46
Category members DSL IPR001774 0.05
Category members Notch_ligand_N IPR011651 0.05
Category members VWF_C IPR001007 0.04
Category members VWC_out IPR006552 0


Protein complexes (CORUM database) featuring JAG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring JAG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0008083 growth factor activity Database 2.34
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members Pathway Pathway_63 BIOCARTA_PTDINS_PATHWAY 0 0.91
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0005112 Notch binding Database 0.14
Category members GO Category GO:0045599 negative regulation of fat cell differentiation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0045639 positive regulation of myeloid cell differentiation Database 0.13
Category members Disease phenotype TETRALOGY_OF_FALLOT TETRALOGY OF FALLOT Database 0.11
Category members GO Category GO:0060411 cardiac septum morphogenesis Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0032495 response to muramyl dipeptide Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0003184 pulmonary valve morphogenesis Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members Pathway Pathway_815 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR 0 0.03
Category members Pathway Pathway_1278 REACTOME_SIGNALING_BY_NOTCH2 0 0
Category members Pathway Pathway_1279 REACTOME_SIGNALING_BY_NOTCH3 0 0
Category members Pathway Pathway_1280 REACTOME_SIGNALING_BY_NOTCH4 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001709 cell fate determination Database 0
Category members GO Category GO:0002011 morphogenesis of an epithelial sheet Database 0
Category members GO Category GO:0003215 cardiac right ventricle morphogenesis Database 0
Category members GO Category GO:0007154 cell communication Database 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0035909 aorta morphogenesis Database 0
Category members GO Category GO:0042491 auditory receptor cell differentiation Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0045445 myoblast differentiation Database 0
Category members GO Category GO:0045446 endothelial cell differentiation Database 0
Category members GO Category GO:0045596 negative regulation of cell differentiation Database 0
Category members GO Category GO:0045747 positive regulation of Notch signaling pathway Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0061156 pulmonary artery morphogenesis Database 0
Category members GO Category GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis Database 0
Category members GO Category GO:0061314 Notch signaling involved in heart development Database 0


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