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Query: SIX2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SIX2 0 0.636 1.040 -0.950 -0.334 0.495

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SIX2 Ubiquitylation K53 0.475 _AK(gl)AVVAFHR_

Background Information for SIX2:


Pubmed-SIX2 »
Uniprot-SIX2 »
Biogrid-SIX2 »
ProteomicsDB-SIX2 »

Tumorportal-SIX2 »
COSMIC-SIX2 »
GenomeRNAi-SIX2 »
Genecards-SIX2


Protein-protein Interactions for SIX2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SIX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SIX2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Homeobox_dom IPR001356 0.63
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring SIX2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SIX2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members GO Category GO:0001656 metanephros development Database 0
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007501 mesodermal cell fate specification Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0042474 middle ear morphogenesis Database 0
Category members GO Category GO:0045596 negative regulation of cell differentiation Database 0


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