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Query: RBPJ

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RBPJ 0 0.684 1.900 -0.160 -0.367 0.284 0.723 -0.090 0.134

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for RBPJ:


Pubmed-RBPJ »
Uniprot-RBPJ »
Biogrid-RBPJ »
ProteomicsDB-RBPJ »

Tumorportal-RBPJ »
COSMIC-RBPJ »
GenomeRNAi-RBPJ »
Genecards-RBPJ


Protein-protein Interactions for RBPJ
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RBPJ Cat. description Hein, Mann, Cell 2015
Category members IP bait CAMK2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO42 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NELF Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RBPJ
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members IPT IPR002909 0.11
Category members p53-like_TF_DNA-bd IPR008967 0
Category members Ig_E-set IPR014756 0


Protein complexes (CORUM database) featuring RBPJ
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2945 RBP-Jkappa-RING1-KyoT2 complex Database 0.6
Category members Corum 3156 CBF1-HDAC1-SMRT complex Database 0.52
Category members Corum 2639 HES1 promoter-Notch enhancer complex Database 0.45
Category members Corum 2908 RBP-Jkappa-SHARP complex Database 0.24
Category members Corum 2930 SHARP-CtIP-RBP-Jkappa complex Database 0.24
Category members Corum 2931 SHARP-CtBP1-CtIP-RBP-Jkappa corepressor complex Database 0.04
Category members Corum 2890 Notch1-fraction 30 complex Database 0.01
Category members Corum 2897 RBPJ-NotchIC-Mastermind complex Database 0.01
Category members Corum 2911 SMRT-SKIP-CBF1 complex Database 0.01
Category members Corum 3113 MAML1-RBP-Jkappa-Notch1 complex Database 0.01
Category members Corum 2638 HES1 promoter corepressor complex Database 0
Category members Corum 2907 RBP-Jkappa-Notch1 complex Database 0
Category members Corum 2946 YY1-Notch1-RBP-Jkappa complex Database 0


Categories featuring RBPJ
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_1173 BIOCARTA_PS1_PATHWAY 0 0.28
Category members GO Category GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0.27
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members Pathway Pathway_891 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 0 0.24
Category members GO Category GO:0048820 hair follicle maturation Database 0.24
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_121 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT 0 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0060045 positive regulation of cardiac muscle cell proliferation Database 0.09
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_113 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 0 0.08
Category members GO Category GO:0042742 defense response to bacterium Database 0.06
Category members GO Category GO:0030513 positive regulation of BMP signaling pathway Database 0.05
Category members GO Category GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0003157 endocardium development Database 0.04
Category members Disease phenotype Adams_Oliver_syndrome Adams Oliver syndrome Database 0.04
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0002193 MAML1-RBP-Jkappa- ICN1 complex Database 0.01
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_890 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members Disease phenotype Adams-Oliver_syndrome Adams-Oliver syndrome Database 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001837 epithelial to mesenchymal transition Database 0
Category members GO Category GO:0001974 blood vessel remodeling Database 0
Category members GO Category GO:0002437 inflammatory response to antigenic stimulus Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0003160 endocardium morphogenesis Database 0
Category members GO Category GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation Database 0
Category members GO Category GO:0003214 cardiac left ventricle morphogenesis Database 0
Category members GO Category GO:0003222 ventricular trabecula myocardium morphogenesis Database 0
Category members GO Category GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006959 humoral immune response Database 0
Category members GO Category GO:0007221 positive regulation of transcription of Notch receptor target Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009912 auditory receptor cell fate commitment Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0021983 pituitary gland development Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0030279 negative regulation of ossification Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0035912 dorsal aorta morphogenesis Database 0
Category members GO Category GO:0036302 atrioventricular canal development Database 0
Category members GO Category GO:0045165 cell fate commitment Database 0
Category members GO Category GO:0045596 negative regulation of cell differentiation Database 0
Category members GO Category GO:0048505 regulation of timing of cell differentiation Database 0
Category members GO Category GO:0048733 sebaceous gland development Database 0
Category members GO Category GO:0060486 Clara cell differentiation Database 0
Category members GO Category GO:0060716 labyrinthine layer blood vessel development Database 0
Category members GO Category GO:0061314 Notch signaling involved in heart development Database 0


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