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Query: SOX2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SOX2 0 0.918 -0.250 0.870

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SOX2 Phosphorylation S251 0.157 -0.109 _SEASSS(ph)PPVVTSSSHSR_

Background Information for SOX2:


Pubmed-SOX2 »
Uniprot-SOX2 »
Biogrid-SOX2 »
ProteomicsDB-SOX2 »

Tumorportal-SOX2 »
COSMIC-SOX2 »
GenomeRNAi-SOX2 »
Genecards-SOX2


Protein-protein Interactions for SOX2
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in SOX2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMG_box_dom IPR009071 0.31
Category members TF_SOX IPR022097 0


Protein complexes (CORUM database) featuring SOX2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2801 OCT4-SOX2 DNA-protein complex Database 0
Category members Corum 2802 OCT1-SOX2 DNA-protein complex Database 0
Category members Corum 2803 PAX6-SOX2 DNA-protein complex Database 0


Categories featuring SOX2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006325 chromatin organization Database 5.02
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0050910 detection of mechanical stimulus involved in sensory perception of sound Database 0.7
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0021879 forebrain neuron differentiation Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0050767 regulation of neurogenesis Database 0.14
Category members GO Category GO:0000976 transcription regulatory region sequence-specific DNA binding Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Disease phenotype Septo-optic_dysplasia Septo-optic dysplasia Database 0.08
Category members GO Category GO:0030910 olfactory placode formation Database 0.07
Category members GO Category GO:0021984 adenohypophysis development Database 0.06
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members Disease phenotype Isolated_anophthalmia_-_microphthalmia Isolated anophthalmia - microphthalmia Database 0.05
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0048646 anatomical structure formation involved in morphogenesis Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048663 neuron fate commitment Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Disease phenotype Colobomatous_microphthalmia Colobomatous microphthalmia Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0001654 eye development Database 0
Category members GO Category GO:0001708 cell fate specification Database 0
Category members GO Category GO:0001714 endodermal cell fate specification Database 0
Category members GO Category GO:0002052 positive regulation of neuroblast proliferation Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0009611 response to wounding Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0021781 glial cell fate commitment Database 0
Category members GO Category GO:0021983 pituitary gland development Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0030539 male genitalia development Database 0
Category members GO Category GO:0030858 positive regulation of epithelial cell differentiation Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0032526 response to retinoic acid Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0035198 miRNA binding Database 0
Category members GO Category GO:0042472 inner ear morphogenesis Database 0
Category members GO Category GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043586 tongue development Database 0
Category members GO Category GO:0045165 cell fate commitment Database 0
Category members GO Category GO:0045596 negative regulation of cell differentiation Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0045747 positive regulation of Notch signaling pathway Database 0
Category members GO Category GO:0048286 lung alveolus development Database 0
Category members GO Category GO:0048568 embryonic organ development Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0048852 diencephalon morphogenesis Database 0
Category members GO Category GO:0048863 stem cell differentiation Database 0
Category members GO Category GO:0050973 detection of mechanical stimulus involved in equilibrioception Database 0
Category members GO Category GO:0060042 retina morphogenesis in camera-type eye Database 0
Category members GO Category GO:0060235 lens induction in camera-type eye Database 0
Category members GO Category GO:0060441 epithelial tube branching involved in lung morphogenesis Database 0
Category members GO Category GO:0070848 response to growth factor Database 0


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