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Query: ITGB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITGB1 0 1.424 0.390 -0.650 0.101 -0.036

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITGB1 Ubiquitylation K794 0.755 0.604 _SAVTTVVNPK(gl)YEGK_
ITGB1 Ubiquitylation K784 -0.172 0.350 _WDTGENPIYK(gl)SAVTTVVNPK_
ITGB1 Ubiquitylation K774 0.402 _MNAK(gl)WDTGENPIYK_

Background Information for ITGB1:


Pubmed-ITGB1 »
Uniprot-ITGB1 »
Biogrid-ITGB1 »
ProteomicsDB-ITGB1 »

Tumorportal-ITGB1 »
COSMIC-ITGB1 »
GenomeRNAi-ITGB1 »
Genecards-ITGB1


Protein-protein Interactions for ITGB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ITGA9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFSF13B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPAN11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITGB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EGF_extracell IPR013111 0.46
Category members VWF_A IPR002035 0
Category members Integrin_bsu_N IPR002369 0
Category members Integrin_bsu_tail IPR012896 0
Category members Integrin_bsu_cyt_dom IPR014836 0
Category members Integrin_bsu IPR015812 0
Category members Plexin-like_fold IPR016201 0


Protein complexes (CORUM database) featuring ITGB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2398 ITGA3-ITGB1-BSG complex Database 0.29
Category members Corum 2399 ITGA3-ITGB1-CD63 complex Database 0.29
Category members Corum 2400 ITGA3-ITGB1-CD151 complex Database 0.29
Category members Corum 2411 ITGA6-ITGB1-CD151 complex Database 0.29
Category members Corum 2429 ITGA2-ITGB1-CD47 complex Database 0.29
Category members Corum 2853 ITGA5-ITGB1-CAL4A3 complex Database 0.29
Category members Corum 2422 ITGA4-ITGB1-JAM2 complex Database 0.25
Category members Corum 2423 ITGA4-ITGB1-CD47 complex Database 0.25
Category members Corum 2424 ITGA4-ITGB1-CD63 complex Database 0.25
Category members Corum 3059 ITGA11-ITGB1-COL1A1 complex Database 0.25
Category members Corum 2416 ITGB1-RAP1A-PKD1 complex Database 0.17
Category members Corum 3112 ITGA5-ITGB1-SPP1 complex Database 0.11
Category members Corum 2385 ITGA5-ITGB4 complex Database 0.09
Category members Corum 2406 ITGA3-ITGB1 complex Database 0.09
Category members Corum 2413 ITGA6-ITGB1 complex Database 0.09
Category members Corum 2431 ITGA2-ITGB1-COL6A3 complex Database 0.09
Category members Corum 2432 ITGA2-ITGB1 complex Database 0.09
Category members Corum 2434 ITGA1-ITGB1-COL6A3 complex Database 0.09
Category members Corum 3104 ITGB1-NRP1 complex Database 0.09
Category members Corum 2418 ITGA4-ITGB1 complex Database 0.08
Category members Corum 3058 ITGA11-ITGB1 complex Database 0.08
Category members Corum 2885 ITGAV-ITGB1-SPP1 complex Database 0.04
Category members Corum 2383 ITGA5-ITGB1-FN1-TGM2 complex Database 0
Category members Corum 2384 ITGA5-ITGB1-ADAM15 complex Database 0
Category members Corum 2390 CD98-LAT2-ITGB1 complex Database 0
Category members Corum 2395 ITGA7-ITGB1-CD151 complex Database 0
Category members Corum 2396 ITGA7-ITGB1-CD9 complex Database 0
Category members Corum 2397 ITGA7-ITGB1-ITGB1BP3 complex Database 0
Category members Corum 2401 ITGA3-ITGB1-THBS1 complex Database 0
Category members Corum 2417 ITGA4-ITGB1-EMILIN1 complex Database 0
Category members Corum 2419 ITGA4-ITGB1-CD81 complex Database 0
Category members Corum 2420 ITGA4-ITGB1-CD53 complex Database 0
Category members Corum 2421 ITGA4-ITGB1-VCAM1 complex Database 0
Category members Corum 2426 ITGA4-ITGB1-THBS1 complex Database 0
Category members Corum 2428 ITGA4-ITGB1-THBS2 complex Database 0
Category members Corum 2430 ITGA2-ITGB1-CHAD complex Database 0
Category members Corum 2435 ITGA1-ITGB1-PTPN2 complex Database 0
Category members Corum 2436 ITGAV-ITGB1 complex Database 0
Category members Corum 2437 ITGA6-ITGB1-CYR61 complex Database 0
Category members Corum 2440 ITGA9-ITGB1-ADAM9 complex Database 0
Category members Corum 2442 ITGA9-ITGB1-VCAM1 complex Database 0
Category members Corum 2443 ITGA9-ITGB1-TNC complex Database 0
Category members Corum 2444 ITGB1-ITGA9 complex Database 0
Category members Corum 2445 ITGA9-ITGB1-ADAM15 complex Database 0
Category members Corum 2446 ITGA9-ITGB1-FIGF complex Database 0
Category members Corum 2447 ITGA9-ITGB1-ADAM12 complex Database 0
Category members Corum 2850 ITGA5-ITGB1-FN-1-NOV complex Database 0
Category members Corum 2971 ITGA9-ITGB1-VEGFC complex Database 0
Category members Corum 2972 ITGA9-ITGB1-VEGFA complex Database 0
Category members Corum 2989 ITGA9-ITGB1-ADAM8 complex Database 0
Category members Corum 3035 LAT2-ITGB1 complex Database 0
Category members Corum 3057 ITGA10-ITGB1 complex Database 0
Category members Corum 3111 ITGA9-ITGB1-SPP1 complex Database 0


Categories featuring ITGB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members GO Category GO:0001618 virus receptor activity Database 0.83
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0019900 kinase binding Database 0.45
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members GO Category GO:0055037 recycling endosome Database 0.29
Category members GO Category GO:0007156 homophilic cell adhesion Database 0.28
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_1093 PID_SYNDECAN_4_PATHWAY 0 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Pathway Pathway_1135 PID_PRL_SIGNALING_EVENTS_PATHWAY 0 0.27
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0005912 adherens junction Database 0.25
Category members Pathway Pathway_536 BIOCARTA_ECM_PATHWAY 0 0.25
Category members GO Category GO:0008354 germ cell migration Database 0.21
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members Pathway Pathway_710 PID_UPA_UPAR_PATHWAY 0 0.2
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Pathway Pathway_923 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS 0 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0030056 hemidesmosome Database 0.1
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members GO Category GO:0031345 negative regulation of cell projection organization Database 0.09
Category members GO Category GO:0034667 alpha3-beta1 integrin complex Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1158 BIOCARTA_EPHA4_PATHWAY 0 0.08
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members Pathway Pathway_647 BIOCARTA_NKCELLS_PATHWAY 0 0.06
Category members GO Category GO:0035748 myelin sheath abaxonal region Database 0.06
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0030175 filopodium Database 0.05
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members Pathway Pathway_680 BIOCARTA_SPPA_PATHWAY 0 0.05
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members Pathway Pathway_1284 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS 0 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0008305 integrin complex Database 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members Pathway Pathway_1235 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN 0 0.02
Category members Pathway Pathway_617 BIOCARTA_TFF_PATHWAY 0 0.02
Category members GO Category GO:0005518 collagen binding Database 0.02
Category members GO Category GO:0002042 cell migration involved in sprouting angiogenesis Database 0.01
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members Pathway Pathway_927 REACTOME_BASIGIN_INTERACTIONS 0 0
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members GO Category GO:0051393 alpha-actinin binding Database 0
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1024 PID_INTEGRIN_A4B1_PATHWAY 0 0
Category members Pathway Pathway_1027 PID_INTEGRIN1_PATHWAY 0 0
Category members Pathway Pathway_1069 BIOCARTA_MCALPAIN_PATHWAY 0 0
Category members Pathway Pathway_1072 BIOCARTA_ERK_PATHWAY 0 0
Category members Pathway Pathway_1122 BIOCARTA_LYM_PATHWAY 0 0
Category members Pathway Pathway_1123 BIOCARTA_LAIR_PATHWAY 0 0
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_1218 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 0 0
Category members Pathway Pathway_1285 BIOCARTA_MONOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1286 PID_INTEGRIN_CS_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_424 KEGG_LEISHMANIA_INFECTION 0 0
Category members Pathway Pathway_426 PID_INTEGRIN_A9B1_PATHWAY 0 0
Category members Pathway Pathway_539 PID_LYMPH_ANGIOGENESIS_PATHWAY 0 0
Category members Pathway Pathway_544 BIOCARTA_BCELLSURVIVAL_PATHWAY 0 0
Category members Pathway Pathway_553 BIOCARTA_PTEN_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members GO Category GO:0001669 acrosomal vesicle Database 0
Category members GO Category GO:0001708 cell fate specification Database 0
Category members GO Category GO:0001894 tissue homeostasis Database 0
Category members GO Category GO:0001948 glycoprotein binding Database 0
Category members GO Category GO:0001968 fibronectin binding Database 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0006968 cellular defense response Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007159 leukocyte cell-cell adhesion Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0007161 calcium-independent cell-matrix adhesion Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0008277 regulation of G-protein coupled receptor protein signaling pathway Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010811 positive regulation of cell-substrate adhesion Database 0
Category members GO Category GO:0014823 response to activity Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0021943 formation of radial glial scaffolds Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0031667 response to nutrient levels Database 0
Category members GO Category GO:0033631 cell-cell adhesion mediated by integrin Database 0
Category members GO Category GO:0034677 alpha7-beta1 integrin complex Database 0
Category members GO Category GO:0034678 alpha8-beta1 integrin complex Database 0
Category members GO Category GO:0034679 alpha9-beta1 integrin complex Database 0
Category members GO Category GO:0034698 response to gonadotropin Database 0
Category members GO Category GO:0042277 peptide binding Database 0
Category members GO Category GO:0043236 laminin binding Database 0
Category members GO Category GO:0045214 sarcomere organization Database 0
Category members GO Category GO:0045596 negative regulation of cell differentiation Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0045807 positive regulation of endocytosis Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0050776 regulation of immune response Database 0
Category members GO Category GO:0050839 cell adhesion molecule binding Database 0
Category members GO Category GO:0055007 cardiac muscle cell differentiation Database 0
Category members GO Category GO:0060135 maternal process involved in female pregnancy Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0
Category members GO Category GO:0071305 cellular response to vitamin D Database 0


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