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BIOCARTA_MCALPAIN_PATHWAY
(Pathway_1069)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
EZR 1 -0.240 -0.210 2.501 -2.209 0.246 0.091
PRKAR1A 1 -0.550 0.230
PRKAR1A 1 -0.550 0.230
TLN1 1 -0.130 0.000 0.807 0.246 0.137
PRKAR1B 1 0.660 -0.470
PRKAR1B 1 0.660 -0.470
PRKAR2B 0 -0.290 0.380
CAPN1 0 0.770 -1.250
CAPN1 0 0.770 -1.250 0.308 0.573 0.029
MYLK 0 -0.520 0.000 0.754
PXN 0 1.020 -0.760
MAPK3 0
PRKAR2A 0 -0.530 1.080 0.026 -1.317 -0.866 0.783 0.007
PRKAR2A 0 -0.530 1.080
CAPNS1 0 1.220 -0.440 0.538 0.797 -0.105
PRKACB 0 1.740 -1.200 -1.064
PRKACB 0 1.740 -1.200 -1.005 -0.697 0.234 0.487
ACTA1 0 -0.170 0.010 -0.189 0.025 -0.002 -0.165
ACTA1 0 -0.170 0.010 0.157
EGFR 0 -0.580 0.520 0.513 0.090
ITGB1 0 0.390 -0.650 0.101 -0.036
CAPN2 0 -1.140 1.400 0.314
CAPN2 0 -1.140 1.400 0.522 0.716 -0.611
HRAS 0 1.470 -0.520
ITGA1 0 -0.750 1.480 0.650 0.069
CAPNS2 0 1.300 -1.160 0.538 0.797 -0.105

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CAPN1 Ubiquitylation K79 1.041 _DLGPNSSK(gl)TYGIK_
CAPN1 Ubiquitylation K280 0.470 _GHAYSVTGAK(gl)QVNYR_
CAPN1 Ubiquitylation K359 0.871 0.535 _LEICNLTPDALK(gl)SR_
CAPNS1 Ubiquitylation K172 0.329 _YLWNNIK(gl)R_
CAPNS1 Ubiquitylation K179 0.195 _WQAIYK(gl)QFDTDR_
CAPNS2 Ubiquitylation K172 0.329 _YLWNNIK(gl)R_
CAPNS2 Ubiquitylation K179 0.195 _WQAIYK(gl)QFDTDR_
EGFR Phosphorylation T693 0.486 -0.139 _ELVEPLT(ph)PSGEAPNQALLR_
EGFR Phosphorylation S991 -0.041 _MHLPS(ph)PTDSNFYR_
EZR Ubiquitylation K3 -0.313 -0.251 _PK(gl)PINVR_
EZR Ubiquitylation K79 0.172 -0.032 _ENPLQFK(gl)FR_
EZR Ubiquitylation K139 1.519 0.361 _FGDYNK(gl)EVHK_
EZR Ubiquitylation K162 1.580 0.660 _VMDQHK(gl)LTR_
EZR Ubiquitylation K253 -0.069 _NISFNDK(gl)K_
EZR Ubiquitylation K263 -0.786 _K(gl)APDFVFYAPR_
EZR Ubiquitylation K344 0.598 0.235 _EK(gl)EELMLR_
EZR Ubiquitylation K357 -0.003 _LQDYEEK(gl)TK_
EZR Ubiquitylation K359 0.051 _LQDYEEK(gl)TK_
EZR Ubiquitylation K450 0.393 0.174 _AK(gl)EAQDDLVK_
HRAS Ubiquitylation K170 -1.005 _K(gl)LNPPDESGPGCMSCK_
ITGB1 Ubiquitylation K774 0.402 _MNAK(gl)WDTGENPIYK_
ITGB1 Ubiquitylation K784 -0.172 0.350 _WDTGENPIYK(gl)SAVTTVVNPK_
ITGB1 Ubiquitylation K794 0.755 0.604 _SAVTTVVNPK(gl)YEGK_
MAPK3 Phosphorylation Y204 -0.807 -2.487 _IADPEHDHTGFLTEY(ph)VATR_
MAPK3 Ubiquitylation K289 -0.608 _NYLQSLPSKTK(gl)_
PRKACB Ubiquitylation K30 -0.143 _AKEDFLKK(gl)_
PRKACB Ubiquitylation K93 0.839 0.714 _QIEHTLNEK(gl)R_
PRKACB Phosphorylation T243 -0.835 _T(ph)WTLCGTPEYLAPEIILSK_
PRKACB Phosphorylation T245 -0.116 -0.102 _TWT(ph)LCGTPEYLAPEIILSK_
PRKAR1A Ubiquitylation K63 -1.895 _LEKEEAK(gl)QIQNLQK_
PRKAR1A Ubiquitylation K70 -0.869 0.073 _QIQNLQK(gl)AGTR_
PRKAR1A Phosphorylation S83 -0.969 -0.776 _EDEIS(ph)PPPPNPVVK_
PRKAR1A Ubiquitylation K92 -3.269 -2.395 _TDSREDEISPPPPNPVVK(gl)GR_
PRKAR1A Ubiquitylation K222 0.412 0.536 _TNVK(gl)LWGIDR_
PRKAR1A Ubiquitylation K244 -0.384 3.721 _K(gl)MYEEFLSK_
PRKAR1A Ubiquitylation K261 -0.886 _VSILESLDK(gl)WER_
PRKAR1A Ubiquitylation K346 0.329 _GPLK(gl)CVK_
PRKAR1A Ubiquitylation K349 -0.425 -0.103 _CVK(gl)LDRPR_
PRKAR1A Ubiquitylation K367 -0.939 0.044 _VLGPCSDILK(gl)R_
PRKAR1B Phosphorylation S3 0.185 0.343 _(ac)AS(ph)PPACPSEEDESLKGCELYVQLHGIQQVLK_
PRKAR1B Ubiquitylation K244 -0.384 3.721 _K(gl)MYEEFLSK_
PRKAR1B Ubiquitylation K346 0.329 _GPLK(gl)CVK_
PRKAR1B Ubiquitylation K349 -0.425 -0.103 _CVK(gl)LDRPR_
PRKAR2A Phosphorylation S99 0.020 0.056 _RVS(ph)VCAETYNPDEEEEDTDPR_
PRKAR2A Phosphorylation T104 -0.175 _RVSVCAET(ph)YNPDEEEEDTDPR_
PRKAR2A Ubiquitylation K359 0.640 _GQYFGELALVTNK(gl)PR_
PRKAR2B Phosphorylation T69 -0.367 _TWGDLGAAAGGGT(ph)PSK_
PRKAR2B Phosphorylation S114 0.366 0.525 _RAS(ph)VCAEAYNPDEEEDDAESR_
PRKAR2B Ubiquitylation K359 0.640 _GQYFGELALVTNK(gl)PR_
PXN Phosphorylation S85 -0.156 0.192 _FIHQQPQSSS(ph)PVYGSSAK_
PXN Phosphorylation T136 1.322 _SAEPSPTVMST(ph)SLGSNLSELDR_
PXN Phosphorylation S140 -0.291 -0.948 _SAEPSPTVM(ox)STSLGS(ph)NLSELDR_
PXN Phosphorylation S302 -0.167 _S(ph)SPGGQDEGGFMAQGK_
PXN Phosphorylation S303 -0.167 _S(ph)SPGGQDEGGFMAQGK_
PXN Phosphorylation S322 -1.234 _TGSSS(ph)PPGGPPKPGSQLDSMLGSLQSDLNK_
TLN1 Ubiquitylation K334 -0.489 0.561 _LLGITK(gl)ECVM(ox)R_
TLN1 Phosphorylation S423 0.105 _DHFGLEGDEESTMLEDS(ph)VSPKK_
TLN1 Phosphorylation S425 -0.366 -0.322 _DHFGLEGDEESTMLEDSVS(ph)PKK_
TLN1 Ubiquitylation K869 -0.260 _ILADATAK(gl)MVEAAK_
TLN1 Ubiquitylation K1541 0.365 2.311 _EVANSTANLVK(gl)TIK_
TLN1 Ubiquitylation K2021 0.309 0.479 _EGILK(gl)TAK_


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