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Query: PRKAR1A

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKAR1A 1 2.617 -0.550 0.230

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKAR1A Ubiquitylation K244 -0.384 3.721 _K(gl)MYEEFLSK_
PRKAR1A Ubiquitylation K222 0.412 0.536 _TNVK(gl)LWGIDR_
PRKAR1A Ubiquitylation K346 0.329 _GPLK(gl)CVK_
PRKAR1A Ubiquitylation K70 -0.869 0.073 _QIQNLQK(gl)AGTR_
PRKAR1A Ubiquitylation K367 -0.939 0.044 _VLGPCSDILK(gl)R_
PRKAR1A Ubiquitylation K349 -0.425 -0.103 _CVK(gl)LDRPR_
PRKAR1A Phosphorylation S83 -0.969 -0.776 _EDEIS(ph)PPPPNPVVK_
PRKAR1A Ubiquitylation K92 -3.269 -2.395 _TDSREDEISPPPPNPVVK(gl)GR_
PRKAR1A Ubiquitylation K63 -1.895 _LEKEEAK(gl)QIQNLQK_
PRKAR1A Ubiquitylation K261 -0.886 _VSILESLDK(gl)WER_

Background Information for PRKAR1A:


Pubmed-PRKAR1A »
Uniprot-PRKAR1A »
Biogrid-PRKAR1A »
ProteomicsDB-PRKAR1A »

Tumorportal-PRKAR1A »
COSMIC-PRKAR1A »
GenomeRNAi-PRKAR1A »
Genecards-PRKAR1A


Protein-protein Interactions for PRKAR1A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GSK3B Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKACB Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAR2A Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKACB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKACG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKAR2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKAR1A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members cNMP-bd_dom IPR000595 0
Category members cAMP/cGMP_kin IPR002373 0
Category members cAMP_dep_PK_reg_su_I/II_a/b IPR003117 0
Category members cAMP_dep_PK_reg_su IPR012198 0
Category members cNMP-bd-like IPR018490 0


Protein complexes (CORUM database) featuring PRKAR1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PRKAR1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members GO Category GO:0031588 AMP-activated protein kinase complex Database 0.54
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_948 BIOCARTA_CARM1_PATHWAY 0 0.17
Category members GO Category GO:0034236 protein kinase A catalytic subunit binding Database 0.14
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0001707 mesoderm formation Database 0.11
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0050796 regulation of insulin secretion Database 0.06
Category members Pathway Pathway_236 BIOCARTA_MPR_PATHWAY 0 0.06
Category members Pathway Pathway_1138 BIOCARTA_STATHMIN_PATHWAY 0 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0001932 regulation of protein phosphorylation Database 0.04
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members Pathway Pathway_251 REACTOME_DAG_AND_IP3_SIGNALING 0 0.02
Category members GO Category GO:0045859 regulation of protein kinase activity Database 0.01
Category members Pathway Pathway_235 BIOCARTA_PLCE_PATHWAY 0 0.01
Category members Pathway Pathway_1024 PID_INTEGRIN_A4B1_PATHWAY 0 0
Category members Pathway Pathway_1069 BIOCARTA_MCALPAIN_PATHWAY 0 0
Category members Pathway Pathway_1130 BIOCARTA_GATA3_PATHWAY 0 0
Category members Pathway Pathway_1154 BIOCARTA_SHH_PATHWAY 0 0
Category members Pathway Pathway_212 BIOCARTA_IGF1R_PATHWAY 0 0
Category members Pathway Pathway_218 BIOCARTA_GPCR_PATHWAY 0 0
Category members Pathway Pathway_222 REACTOME_CA_DEPENDENT_EVENTS 0 0
Category members Pathway Pathway_227 REACTOME_PLC_BETA_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_239 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB 0 0
Category members Pathway Pathway_241 BIOCARTA_CSK_PATHWAY 0 0
Category members Pathway Pathway_242 REACTOME_AQUAPORIN_MEDIATED_TRANSPORT 0 0
Category members Pathway Pathway_245 BIOCARTA_CFTR_PATHWAY 0 0
Category members Pathway Pathway_246 REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION 0 0
Category members Pathway Pathway_248 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS 0 0
Category members Pathway Pathway_249 BIOCARTA_CREB_PATHWAY 0 0
Category members Pathway Pathway_250 BIOCARTA_BAD_PATHWAY 0 0
Category members Pathway Pathway_261 REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_271 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 0 0
Category members Pathway Pathway_301 BIOCARTA_NO1_PATHWAY 0 0
Category members Pathway Pathway_359 BIOCARTA_DREAM_PATHWAY 0 0
Category members Pathway Pathway_421 BIOCARTA_NOS1_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_676 BIOCARTA_CK1_PATHWAY 0 0
Category members Pathway Pathway_702 BIOCARTA_VIP_PATHWAY 0 0
Category members Pathway Pathway_993 BIOCARTA_AGPCR_PATHWAY 0 0
Category members Disease phenotype Acrodysostosis Acrodysostosis Database 0
Category members Disease phenotype Acrodysostosis_with_multiple_hormone_resistance Acrodysostosis with multiple hormone resistance Database 0
Category members Disease phenotype Primary_pigmented_nodular_adrenocortical_disease Primary pigmented nodular adrenocortical disease Database 0
Category members GO Category GO:0004862 cAMP-dependent protein kinase inhibitor activity Database 0
Category members GO Category GO:0005952 cAMP-dependent protein kinase complex Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0006833 water transport Database 0
Category members GO Category GO:0007143 female meiosis Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007202 activation of phospholipase C activity Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0008603 cAMP-dependent protein kinase regulator activity Database 0
Category members GO Category GO:0030552 cAMP binding Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0034199 activation of protein kinase A activity Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0045214 sarcomere organization Database 0
Category members GO Category GO:0045835 negative regulation of meiosis Database 0
Category members GO Category GO:0060038 cardiac muscle cell proliferation Database 0
Category members GO Category GO:0071377 cellular response to glucagon stimulus Database 0


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