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Results for the Category
REACTOME_OPIOID_SIGNALLING
(Pathway_260)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
PPP1CA 3 2.150 -0.860
PPP1CA 3 2.150 -0.860 -0.250 0.634 0.981 -0.108 0.171
ITPR3 2 -0.190 -0.500 1.489 1.835
GNAI3 1 0.750 -0.890
GNAI3 1 0.750 -0.890 0.217 -0.334 -0.374
GNAO1 1 1.200 -1.320
GNAO1 1 1.200 -1.320 0.217 -0.334 -0.374
PPP2CB 1 2.210 -0.980 0.194 0.044 0.215
PPP2CB 1 2.210 -0.980 0.650 1.189
PPP2R1A 1 -0.260 -0.200 0.714 0.973
PPP2R1A 1 -0.260 -0.200 -0.003 -0.196 0.057
PPP2R1A 1 -0.260 -0.200 1.697 1.450 -1.553
PPP2R1B 1 1.240 -0.730 1.697 1.450 -1.553
PRKAR1A 1 -0.550 0.230
PRKAR1A 1 -0.550 0.230
PPP2R5D 1 -0.110 0.620
PPP2R5D 1 -0.110 0.620 -0.455 -0.019
ADCY3 1 -0.850 1.180
CALM2 1 -0.690 0.700 1.911
CALM2 1 -0.690 0.700 0.877 -4.680
CALM3 1 -0.190 0.120 1.911
CALM3 1 -0.190 0.120 0.877 -4.680
PRKAR1B 1 0.660 -0.470
PRKAR1B 1 0.660 -0.470
CALM1 1 -0.440 0.360 1.911
CALM1 1 -0.440 0.360 0.877 -4.680
PRKAR2B 0 -0.290 0.380
GNAI1 0 -0.580 0.990
GNAI2 0 0.190 -0.520
GNAL 0 1.660 -1.170
GNAS 0 0.840 -0.750
GNAT1 0 -0.110 -0.270
GNAT2 0 0.140 -0.880
GNAT3 0 1.110 -0.500
PRKACA 0 0.380 -0.680 -1.005 -0.697 0.234 0.487
GNB1 0 -0.700 0.650 0.713 0.504 0.538
GNB3 0 -1.020 1.280 0.713 0.504 0.538
PDYN 0 0.350 -0.620
PLCB4 0 0.640 -0.400
PPP3CB 0 -1.240 2.140 -0.298 1.130
PPP3CB 0 -1.240 2.140 0.923 0.537
PPP2CA 0 0.160 -0.540 0.194 0.044 0.215
PPP2CA 0 0.160 -0.540 0.650 1.189
PRKAR2A 0 -0.530 1.080 0.026 -1.317 -0.866 0.783 0.007
PRKAR2A 0 -0.530 1.080
GNAT1 0 -0.110 -0.270
GNAT1 0 -0.110 -0.270 -0.166 -0.094 0.032 0.420 0.504
GNB4 0 0.410 -0.240 0.137 0.627 1.296
GNB4 0 0.410 -0.240
CREB1 0 1.080 -0.800 -1.027
ADCY7 0
ITPR2 0 -1.020 0.610 0.952 0.981
GNAI1 0 -0.580 0.990 0.116 -0.747
GNAZ 0 -0.020 -0.560
GNAT2 0 0.140 -0.880 -0.166 -0.094 0.032 0.420 0.504
PPP3CA 0 1.550 -1.230 -0.298 1.130
PPP3CA 0 1.550 -1.230 0.923 0.537
GNAL 0 1.660 -1.170
GNAL 0 1.660 -1.170 -0.166 -0.094 0.032 0.420 0.504
PRKACB 0 1.740 -1.200 -1.064
PRKACB 0 1.740 -1.200 -1.005 -0.697 0.234 0.487
CAMK4 0 0.780 -0.790
PRKCA 0 0.750 -0.690 0.349 0.585
PRKCA 0 0.750 -0.690
ADCY9 0 -0.910 0.930
PRKCD 0 0.250 0.070 0.578 0.427
CDK5 0 -1.100 1.740 -0.236 1.063 0.312
GNG4 0 0.310 -0.680
GNB2 0 0.120 -0.090 0.137 0.627 1.296
GNG12 0 1.160 -1.150 -1.317
GNG12 0 1.160 -1.150
ADRBK1 0 -0.390 0.360
ADRBK1 0 -0.340 0.480
GNG5 0 -0.100 -0.480
ADCY6 0 -0.720 0.740
PLCB1 0 -0.300 -0.220

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ADCY3 Ubiquitylation K406 -0.885 _TK(gl)TGVDMR_
ADCY3 Ubiquitylation K628 0.051 _YSVEK(gl)EK_
ADCY3 Ubiquitylation K879 0.818 2.820 _IEVHDQK(gl)ER_
ADCY3 Ubiquitylation K1047 -1.036 _IGMNK(gl)GGVLAGVIGAR_
ADCY6 Phosphorylation S54 -1.434 -1.374 _DAEPPS(ph)PTPAGPPR_
ADCY6 Ubiquitylation K80 0.473 0.937 _GK(gl)ELGLR_
ADCY6 Ubiquitylation K568 1.007 0.799 _AMLAK(gl)LQR_
ADCY6 Phosphorylation S576 -0.020 _ANS(ph)MEGLMPR_
ADCY7 Ubiquitylation K477 0.660 _GDAALK(gl)MR_
ADCY9 Ubiquitylation K35 0.400 _INPK(gl)QLSSNSHPK_
ADCY9 Ubiquitylation K564 0.874 0.253 _LGQSVVADQLK(gl)GLK_
ADCY9 Ubiquitylation K622 0.176 0.287 _GQGTASSGNVSDLAQTVK(gl)TFDNLK_
ADCY9 Ubiquitylation K628 0.266 _TFDNLK(gl)TCPSCGITFAPK_
ADCY9 Ubiquitylation K699 1.085 _LTNSQTSLCEILQEK(gl)GR_
ADCY9 Ubiquitylation K1218 1.351 1.067 _VLSK(gl)MGYDFDYR_
ADRBK1 Phosphorylation S670 1.038 0.924 _NKPRS(ph)PVVELSK_
ADRBK1 Phosphorylation S676 1.113 _NKPRSPVVELS(ph)K_
CALM1 Ubiquitylation K78 0.061 _DGDGTITTK(gl)ELGTVMR_
CALM1 Ubiquitylation K142 0.922 _VFDK(gl)DGNGYISAAELR_
CALM2 Ubiquitylation K78 0.061 _DGDGTITTK(gl)ELGTVMR_
CALM2 Ubiquitylation K142 0.922 _VFDK(gl)DGNGYISAAELR_
CALM3 Ubiquitylation K78 0.061 _DGDGTITTK(gl)ELGTVMR_
CALM3 Ubiquitylation K142 0.922 _VFDK(gl)DGNGYISAAELR_
CAMK4 Phosphorylation S360 -0.256 0.086 _DPS(ph)PIQDGNEDMK_
CDK5 Ubiquitylation K56 0.606 0.237 _EICLLK(gl)ELK_
CREB1 Phosphorylation S271 -0.979 -1.450 _TAPTSTIAPGVVM(ox)ASS(ph)PALPTQPAEEAAR_
CREB1 Ubiquitylation K333 1.343 _ALK(gl)DLYCHK_
GNAI1 Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAI1 Ubiquitylation K92 0.873 0.567 _LK(gl)IDFGDSAR_
GNAI2 Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAI3 Ubiquitylation K29 0.529 -0.094 _NLREDGEK(gl)AAK_
GNAI3 Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAI3 Ubiquitylation K92 1.569 _LK(gl)IDFGEAAR_
GNAI3 Ubiquitylation K349 -0.221 -0.339 _NNLK(gl)ECGLY_
GNAL Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAL Ubiquitylation K58 -1.182 0.161 _STIVK(gl)QM(ox)R_
GNAO1 Ubiquitylation K29 0.529 -0.094 _NLREDGEK(gl)AAK_
GNAO1 Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAO1 Ubiquitylation K92 1.569 _LK(gl)IDFGEAAR_
GNAO1 Ubiquitylation K349 -0.221 -0.339 _NNLK(gl)ECGLY_
GNAS Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAT1 Ubiquitylation K17 0.320 _ELEK(gl)KLK_
GNAT1 Ubiquitylation K18 0.320 _ELEK(gl)KLK_
GNAT1 Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAT2 Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAT3 Ubiquitylation K53 -1.168 -0.413 _LLLLGAGESGK(gl)STIVK_
GNAZ Ubiquitylation K51 0.481 -0.051 _STIVK(gl)QMK_
GNAZ Ubiquitylation K189 0.945 _DMTTGIVENK(gl)FTFK_
GNB1 Ubiquitylation K23 -0.282 _K(gl)ACADATLSQITNNIDPVGR_
GNB1 Ubiquitylation K209 -0.296 -0.249 _LFVSGACDASAK(gl)LWDVR_
GNB2 Ubiquitylation K23 -0.095 0.033 _K(gl)ACGDSTLTQITAGLDPVGR_
GNB2 Ubiquitylation K209 0.251 0.419 _TFVSGACDASIK(gl)LWDVR_
GNB3 Ubiquitylation K23 -0.282 _K(gl)ACADATLSQITNNIDPVGR_
GNB3 Ubiquitylation K209 -0.296 -0.249 _LFVSGACDASAK(gl)LWDVR_
GNB4 Ubiquitylation K23 -0.095 0.033 _K(gl)ACGDSTLTQITAGLDPVGR_
GNB4 Ubiquitylation K23 -0.030 _K(gl)ACNDATLVQITSNMDSVGR_
GNB4 Ubiquitylation K209 0.251 0.419 _TFVSGACDASIK(gl)LWDVR_
GNB4 Ubiquitylation K209 0.019 _TFVSGACDASSK(gl)LWDIR_
GNG12 Ubiquitylation K4 0.230 0.493 _(ac)SSK(gl)TASTNNIAQAR_
GNG12 Ubiquitylation K34 0.515 1.067 _VSK(gl)ASADLMSYCEEHAR_
GNG4 Ubiquitylation K24 1.031 0.205 _KAVEQLK(gl)MEACMDR_
GNG5 Ubiquitylation K11 -0.523 0.125 _(ac)SGSSSVAAMK(gl)K_
GNG5 Ubiquitylation K12 0.232 0.466 _K(gl)VVQQLR_
GNG5 Ubiquitylation K27 -0.760 0.148 _VK(gl)VSQAAADLK_
ITPR2 Ubiquitylation K909 -0.247 _LSK(gl)FQDGGNNVMR_
ITPR2 Phosphorylation S1160 0.443 0.895 _GGEEPIEESNILS(ph)PVQDGTK_
ITPR3 Ubiquitylation K529 1.377 _EK(gl)GGEGPLVR_
ITPR3 Phosphorylation S934 0.318 -0.802 _KQS(ph)VFSAPSLSAGASAAEPLDR_
ITPR3 Phosphorylation S937 -0.026 _KQSVFS(ph)APSLSAGASAAEPLDR_
ITPR3 Ubiquitylation K1534 -0.220 _TLAMVAK(gl)GR_
ITPR3 Phosphorylation S1832 0.650 0.560 _VAS(ph)FSIPGSSSR_
ITPR3 Ubiquitylation K2597 -0.819 _NK(gl)NLDWFPR_
ITPR3 Ubiquitylation K2628 -0.010 _ILQDK(gl)LNSTMK_
ITPR3 Phosphorylation S2670 1.132 1.555 _LGFVDVQNCIS(ph)R_
PDYN Phosphorylation S101 0.557 0.798 _LSGS(ph)FLK_
PLCB1 Phosphorylation S1199 -0.494 _TPS(ph)SEELGGDIPGKEFDTPL_
PLCB1 Phosphorylation S1200 -0.483 _TPSS(ph)EELGGDIPGKEFDTPL_
PLCB4 Ubiquitylation K284 1.083 0.038 _K(gl)GLISSDGFCR_
PPP1CA Ubiquitylation K6 0.594 0.414 _(ac)SDSEK(gl)LNLDSIIGR_
PPP1CA Ubiquitylation K50 -0.131 0.478 _GLCLK(gl)SR_
PPP1CA Ubiquitylation K150 0.321 0.619 _IYGFYDECK(gl)RR_
PPP1CA Ubiquitylation K156 0.883 1.047 _YNIK(gl)LWK_
PPP1CA Ubiquitylation K247 0.313 _FLHK(gl)HDLDLICR_
PPP1CA Ubiquitylation K269 2.628 2.591 _AHQVVEDGYEFFAK(gl)R_
PPP2CA Ubiquitylation K4 -0.788 -0.378 _(ac)MDDK(gl)AFTK_
PPP2CA Ubiquitylation K4 -0.450 -0.016 _(ac)M(ox)DEK(gl)VFTK_
PPP2CA Ubiquitylation K8 -0.522 _VFTK(gl)ELDQWIEQLNECK_
PPP2CA Ubiquitylation K21 -1.370 _ELDQWVEQLNECK(gl)QLNENQVR_
PPP2CA Ubiquitylation K21 -1.106 _ELDQWIEQLNECK(gl)QLSESQVK_
PPP2CA Ubiquitylation K29 0.211 0.122 _QLSESQVK(gl)SLCEK_
PPP2CA Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CA Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CA Ubiquitylation K41 -0.049 0.003 _EILTK(gl)ESNVQEVR_
PPP2CA Ubiquitylation K74 -0.316 -0.316 _IGGK(gl)SPDTNYLFMGDYVDR_
PPP2CB Ubiquitylation K4 -0.788 -0.378 _(ac)MDDK(gl)AFTK_
PPP2CB Ubiquitylation K4 -0.450 -0.016 _(ac)M(ox)DEK(gl)VFTK_
PPP2CB Ubiquitylation K8 -0.522 _VFTK(gl)ELDQWIEQLNECK_
PPP2CB Ubiquitylation K21 -1.370 _ELDQWVEQLNECK(gl)QLNENQVR_
PPP2CB Ubiquitylation K21 -1.106 _ELDQWIEQLNECK(gl)QLSESQVK_
PPP2CB Ubiquitylation K29 0.211 0.122 _QLSESQVK(gl)SLCEK_
PPP2CB Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CB Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CB Ubiquitylation K41 -0.049 0.003 _EILTK(gl)ESNVQEVR_
PPP2CB Ubiquitylation K74 -0.316 -0.316 _IGGK(gl)SPDTNYLFMGDYVDR_
PPP2R1A Ubiquitylation K34 0.304 _K(gl)LSTIALALGVER_
PPP2R1A Ubiquitylation K107 0.584 0.441 _DK(gl)AVESLR_
PPP2R1A Ubiquitylation K163 0.106 0.149 _VSSAVK(gl)AELR_
PPP2R1A Ubiquitylation K175 -0.351 _ASNAVK(gl)AEIR_
PPP2R1A Ubiquitylation K188 0.395 0.130 _AAASK(gl)LGEFAK_
PPP2R1A Ubiquitylation K255 0.301 0.202 _QAAEDK(gl)SWR_
PPP2R1A Ubiquitylation K266 0.464 0.338 _YMVADK(gl)FTELQK_
PPP2R1A Ubiquitylation K284 -0.575 _FSELQK(gl)AMGPK_
PPP2R1A Ubiquitylation K307 0.224 0.500 _VK(gl)EFCENLSADCR_
PPP2R1A Ubiquitylation K467 0.890 _EAATSNLK(gl)K_
PPP2R1A Ubiquitylation K468 0.890 _EAATSNLK(gl)K_
PPP2R1A Ubiquitylation K542 -0.187 _FNVAK(gl)SLQK_
PPP2R1B Ubiquitylation K175 -0.351 _ASNAVK(gl)AEIR_
PPP2R1B Ubiquitylation K284 -0.575 _FSELQK(gl)AMGPK_
PPP2R5D Phosphorylation T63 -1.449 _RPSNST(ph)PPPTQLSK_
PPP2R5D Ubiquitylation K232 -0.302 _FLESPDFQPNIAK(gl)K_
PPP2R5D Ubiquitylation K233 -0.302 0.665 _FLESPDFQPNIAKK(gl)_
PPP2R5D Ubiquitylation K409 -0.010 _QLAK(gl)CVSSPHFQVAER_
PPP2R5D Phosphorylation S573 0.524 0.357 _RKS(ph)ELPQDVYTIK_
PPP2R5D Phosphorylation S598 -0.317 1.858 _RAEEFLTAS(ph)QEAL_
PPP3CA Ubiquitylation K32 -0.137 _LTAK(gl)EVFDNDGKPR_
PPP3CA Ubiquitylation K56 0.132 _VDVLK(gl)NHLVK_
PPP3CA Ubiquitylation K323 0.705 _AAVLK(gl)YENNVMNIR_
PPP3CA Ubiquitylation K405 0.078 _AIGK(gl)MAR_
PPP3CB Ubiquitylation K32 -0.137 _LTAK(gl)EVFDNDGKPR_
PPP3CB Ubiquitylation K56 0.132 _VDVLK(gl)NHLVK_
PPP3CB Ubiquitylation K323 0.705 _AAVLK(gl)YENNVMNIR_
PPP3CB Ubiquitylation K405 0.078 _AIGK(gl)MAR_
PRKACA Ubiquitylation K30 -0.143 _AKEDFLKK(gl)_
PRKACA Ubiquitylation K93 0.839 0.714 _QIEHTLNEK(gl)R_
PRKACB Ubiquitylation K30 -0.143 _AKEDFLKK(gl)_
PRKACB Ubiquitylation K93 0.839 0.714 _QIEHTLNEK(gl)R_
PRKACB Phosphorylation T243 -0.835 _T(ph)WTLCGTPEYLAPEIILSK_
PRKACB Phosphorylation T245 -0.116 -0.102 _TWT(ph)LCGTPEYLAPEIILSK_
PRKAR1A Ubiquitylation K63 -1.895 _LEKEEAK(gl)QIQNLQK_
PRKAR1A Ubiquitylation K70 -0.869 0.073 _QIQNLQK(gl)AGTR_
PRKAR1A Phosphorylation S83 -0.969 -0.776 _EDEIS(ph)PPPPNPVVK_
PRKAR1A Ubiquitylation K92 -3.269 -2.395 _TDSREDEISPPPPNPVVK(gl)GR_
PRKAR1A Ubiquitylation K222 0.412 0.536 _TNVK(gl)LWGIDR_
PRKAR1A Ubiquitylation K244 -0.384 3.721 _K(gl)MYEEFLSK_
PRKAR1A Ubiquitylation K261 -0.886 _VSILESLDK(gl)WER_
PRKAR1A Ubiquitylation K346 0.329 _GPLK(gl)CVK_
PRKAR1A Ubiquitylation K349 -0.425 -0.103 _CVK(gl)LDRPR_
PRKAR1A Ubiquitylation K367 -0.939 0.044 _VLGPCSDILK(gl)R_
PRKAR1B Phosphorylation S3 0.185 0.343 _(ac)AS(ph)PPACPSEEDESLKGCELYVQLHGIQQVLK_
PRKAR1B Ubiquitylation K244 -0.384 3.721 _K(gl)MYEEFLSK_
PRKAR1B Ubiquitylation K346 0.329 _GPLK(gl)CVK_
PRKAR1B Ubiquitylation K349 -0.425 -0.103 _CVK(gl)LDRPR_
PRKAR2A Phosphorylation S99 0.020 0.056 _RVS(ph)VCAETYNPDEEEEDTDPR_
PRKAR2A Phosphorylation T104 -0.175 _RVSVCAET(ph)YNPDEEEEDTDPR_
PRKAR2A Ubiquitylation K359 0.640 _GQYFGELALVTNK(gl)PR_
PRKAR2B Phosphorylation T69 -0.367 _TWGDLGAAAGGGT(ph)PSK_
PRKAR2B Phosphorylation S114 0.366 0.525 _RAS(ph)VCAEAYNPDEEEDDAESR_
PRKAR2B Ubiquitylation K359 0.640 _GQYFGELALVTNK(gl)PR_
PRKCA Phosphorylation S10 -0.650 0.036 _(ac)ADVFPGNDS(ph)TASQDVANR_
PRKCA Phosphorylation S13 -1.038 0.335 _(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCA Phosphorylation S226 0.693 0.415 _STLNPQWNES(ph)FTFK_
PRKCA Ubiquitylation K316 -0.522 -0.535 _LGPAGNK(gl)VISPSEDR_
PRKCD Ubiquitylation K138 -0.141 _SEDEAK(gl)FPTMNR_
PRKCD Ubiquitylation K222 0.185 0.658 _DTIFQK(gl)ER_
PRKCD Phosphorylation S302 -0.240 -0.222 _S(ph)DSASSEPVGIYQGFEK_
PRKCD Phosphorylation S304 0.378 0.289 _RSDS(ph)ASSEPVGIYQGFEK_
PRKCD Phosphorylation S506 -0.213 0.200 _AS(ph)TFCGTPDYIAPEILQGLK_
PRKCD Phosphorylation T507 -0.149 0.240 _AS(ph)TFCGTPDYIAPEILQGLK_
PRKCD Ubiquitylation K641 -2.000 _DYSNFDQEFLNEK(gl)AR_
PRKCD Phosphorylation S645 0.577 0.832 _ARLS(ph)YSDK_
PRKCD Phosphorylation S647 0.886 0.853 _ARLSYS(ph)DK_


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