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Query: PPP2CB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPP2CB 1 2.690 2.210 -0.980 0.650 1.189
PPP2CB 1 2.690 2.210 -0.980 0.194 0.044 0.215

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPP2CB Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CB Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CB Ubiquitylation K29 0.211 0.122 _QLSESQVK(gl)SLCEK_
PPP2CB Ubiquitylation K41 -0.049 0.003 _EILTK(gl)ESNVQEVR_
PPP2CB Ubiquitylation K4 -0.450 -0.016 _(ac)M(ox)DEK(gl)VFTK_
PPP2CB Ubiquitylation K74 -0.316 -0.316 _IGGK(gl)SPDTNYLFMGDYVDR_
PPP2CB Ubiquitylation K4 -0.788 -0.378 _(ac)MDDK(gl)AFTK_
PPP2CB Ubiquitylation K21 -1.370 _ELDQWVEQLNECK(gl)QLNENQVR_
PPP2CB Ubiquitylation K8 -0.522 _VFTK(gl)ELDQWIEQLNECK_
PPP2CB Ubiquitylation K21 -1.106 _ELDQWIEQLNECK(gl)QLSESQVK_

Background Information for PPP2CB:


Pubmed-PPP2CB »
Uniprot-PPP2CB »
Biogrid-PPP2CB »
ProteomicsDB-PPP2CB »

Tumorportal-PPP2CB »
COSMIC-PPP2CB »
GenomeRNAi-PPP2CB »
Genecards-PPP2CB


Protein-protein Interactions for PPP2CB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait IGBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2D Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait FOXD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPP2CB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ser/Thr-sp_prot-phosphatase IPR006186 0.88
Category members Calcineurin-like_PHP_apaH IPR004843 0.24
Category members Metallo-depent_PP-like IPR029052 0.23


Protein complexes (CORUM database) featuring PPP2CB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5211 RAF1-PPP2-PIN1 complex Database 0


Categories featuring PPP2CB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_57 REACTOME_GLYCOLYSIS 0 4.41
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_807 REACTOME_SIGNALING_BY_WNT 0 2.74
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_1257 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE 0 1.21
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_936 REACTOME_CTLA4_INHIBITORY_SIGNALING 0 0.77
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members Pathway Pathway_720 REACTOME_PLATELET_SENSITIZATION_BY_LDL 0 0.29
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0046580 negative regulation of Ras protein signal transduction Database 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members Pathway Pathway_1001 REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 0 0.2
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members Pathway Pathway_312 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 0 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_810 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 0 0.09
Category members GO Category GO:0046677 response to antibiotic Database 0.08
Category members Pathway Pathway_285 REACTOME_PLATELET_HOMEOSTASIS 0 0.08
Category members GO Category GO:0034976 response to endoplasmic reticulum stress Database 0.06
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members GO Category GO:0008637 apoptotic mitochondrial changes Database 0.01
Category members Pathway Pathway_1063 REACTOME_ERK_MAPK_TARGETS 0 0
Category members Pathway Pathway_1064 REACTOME_ERKS_ARE_INACTIVATED 0 0
Category members Pathway Pathway_1065 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 0 0
Category members Pathway Pathway_783 REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 0 0
Category members GO Category GO:0000159 protein phosphatase type 2A complex Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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