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Query: GNB1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GNB1 0 1.874 -0.700 0.650 0.713 0.504 0.538

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GNB1 Ubiquitylation K209 -0.296 -0.249 _LFVSGACDASAK(gl)LWDVR_
GNB1 Ubiquitylation K23 -0.282 _K(gl)ACADATLSQITNNIDPVGR_

Background Information for GNB1:


Pubmed-GNB1 »
Uniprot-GNB1 »
Biogrid-GNB1 »
ProteomicsDB-GNB1 »

Tumorportal-GNB1 »
COSMIC-GNB1 »
GenomeRNAi-GNB1 »
Genecards-GNB1


Protein-protein Interactions for GNB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT4 Cat. description Hein, Mann, Cell 2015
Category members IP bait GNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait GNAI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNAI3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNAS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GNB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12
Category members Gprotein_B IPR001632 0
Category members Guanine_nucleotide-bd_bsu IPR016346 0


Protein complexes (CORUM database) featuring GNB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1612 Heterotrimeric G protein complex (GNG2, GNB1, GNAS) Database 0.09
Category members Corum 1614 G protein complex (MCF2, GNB1, GNG2) Database 0.09
Category members Corum 1615 G protein complex (BTK, GNG1, GNG2) Database 0
Category members Corum 1618 G protein complex (PTHR1, GNB1, GNG2) Database 0
Category members Corum 1619 G protein complex (HDAC5, GNB1, GNG2) Database 0
Category members Corum 1620 G protein complex (HDAC4, GNB1, GNG2) Database 0


Categories featuring GNB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_1105 REACTOME_GPCR_LIGAND_BINDING 0 2.35
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_1104 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 0 0.93
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_1198 REACTOME_OLFACTORY_SIGNALING_PATHWAY 0 0.82
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members Pathway Pathway_677 BIOCARTA_MYOSIN_PATHWAY 0 0.53
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_263 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 0 0.49
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0030425 dendrite Database 0.26
Category members Pathway Pathway_253 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 0 0.26
Category members GO Category GO:0007603 phototransduction, visible light Database 0.25
Category members Pathway Pathway_1102 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS 0 0.25
Category members Pathway Pathway_228 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 0 0.24
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members Pathway Pathway_760 REACTOME_POTASSIUM_CHANNELS 0 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_428 PID_THROMBIN_PAR1_PATHWAY 0 0.18
Category members GO Category GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway Database 0.18
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_525 BIOCARTA_CXCR4_PATHWAY 0 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members Pathway Pathway_285 REACTOME_PLATELET_HOMEOSTASIS 0 0.08
Category members Pathway Pathway_721 REACTOME_SIGNAL_AMPLIFICATION 0 0.06
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Pathway Pathway_236 BIOCARTA_MPR_PATHWAY 0 0.06
Category members Pathway Pathway_680 BIOCARTA_SPPA_PATHWAY 0 0.05
Category members Pathway Pathway_523 BIOCARTA_CCR3_PATHWAY 0 0.04
Category members Pathway Pathway_288 PID_RHODOPSIN_PATHWAY 0 0.04
Category members Pathway Pathway_486 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 0 0.04
Category members GO Category GO:0016056 rhodopsin mediated signaling pathway Database 0.04
Category members Pathway Pathway_663 PID_IL8_CXCR1_PATHWAY 0 0.01
Category members GO Category GO:0022400 regulation of rhodopsin mediated signaling pathway Database 0
Category members Pathway Pathway_1072 BIOCARTA_ERK_PATHWAY 0 0
Category members Pathway Pathway_1100 REACTOME_G_PROTEIN_ACTIVATION 0 0
Category members Pathway Pathway_1101 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR 0 0
Category members Pathway Pathway_1103 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR 0 0
Category members Pathway Pathway_1106 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 0 0
Category members Pathway Pathway_1107 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_215 REACTOME_GABA_RECEPTOR_ACTIVATION 0 0
Category members Pathway Pathway_216 BIOCARTA_EDG1_PATHWAY 0 0
Category members Pathway Pathway_217 BIOCARTA_BARRESTIN_PATHWAY 0 0
Category members Pathway Pathway_218 BIOCARTA_GPCR_PATHWAY 0 0
Category members Pathway Pathway_219 REACTOME_GABA_B_RECEPTOR_ACTIVATION 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_231 BIOCARTA_BARRESTIN_SRC_PATHWAY 0 0
Category members Pathway Pathway_241 BIOCARTA_CSK_PATHWAY 0 0
Category members Pathway Pathway_242 REACTOME_AQUAPORIN_MEDIATED_TRANSPORT 0 0
Category members Pathway Pathway_246 REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION 0 0
Category members Pathway Pathway_248 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_264 BIOCARTA_BARR_MAPK_PATHWAY 0 0
Category members Pathway Pathway_268 KEGG_TASTE_TRANSDUCTION 0 0
Category members Pathway Pathway_269 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE 0 0
Category members Pathway Pathway_271 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_439 BIOCARTA_GCR_PATHWAY 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_524 BIOCARTA_FMLP_PATHWAY 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members Pathway Pathway_624 PID_AR_NONGENOMIC_PATHWAY 0 0
Category members Pathway Pathway_655 PID_CXCR3_PATHWAY 0 0
Category members Pathway Pathway_661 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA 0 0
Category members Pathway Pathway_664 REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING 0 0
Category members Pathway Pathway_675 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA 0 0
Category members Pathway Pathway_678 REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING 0 0
Category members Pathway Pathway_684 PID_THROMBIN_PAR4_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_722 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 0 0
Category members Pathway Pathway_761 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS 0 0
Category members Pathway Pathway_993 BIOCARTA_AGPCR_PATHWAY 0 0
Category members Pathway Pathway_994 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 0 0
Category members GO Category GO:0001750 photoreceptor outer segment Database 0
Category members GO Category GO:0001917 photoreceptor inner segment Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005834 heterotrimeric G-protein complex Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway Database 0
Category members GO Category GO:0007204 positive regulation of cytosolic calcium ion concentration Database 0
Category members GO Category GO:0007213 G-protein coupled acetylcholine receptor signaling pathway Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0010659 cardiac muscle cell apoptotic process Database 0
Category members GO Category GO:0042622 photoreceptor outer segment membrane Database 0
Category members GO Category GO:0044297 cell body Database 0
Category members GO Category GO:0050909 sensory perception of taste Database 0
Category members GO Category GO:0051020 GTPase binding Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0
Category members GO Category GO:0071377 cellular response to glucagon stimulus Database 0
Category members GO Category GO:0071380 cellular response to prostaglandin E stimulus Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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