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BIOCARTA_CXCR4_PATHWAY
(Pathway_525)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
PLCG1 1 -0.170 0.000
RAF1 1 2.020 -1.230
MAP2K1 1 -1.590 2.780
GNB1 0 -0.700 0.650 0.713 0.504 0.538
GNB3 0 -1.020 1.280 0.713 0.504 0.538
PXN 0 1.020 -0.760
MAPK3 0
NFKB1 0 0.720 -0.810
PIK3CA 0
CXCR4 0 0.640 -0.440
GNAI1 0 -0.580 0.990 0.116 -0.747
PIK3R1 0 1.910 -1.220 -0.441 0.147
PRKCA 0 0.750 -0.690 0.349 0.585
PRKCA 0 0.750 -0.690
GNAQ 0 0.140 -0.310 0.052 0.449
PRKCB 0 0.260 -0.530
PRKCB 0 0.260 -0.530 0.349 0.585
CRK 0 -0.790 0.230
RELA 0 -1.130 1.600 0.793
HRAS 0 1.470 -0.520

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CRK Phosphorylation S40 0.533 0.363 _DS(ph)STSPGDYVLSVSENSR_
CRK Phosphorylation S41 1.065 0.801 _DSS(ph)TSPGDYVLSVSENSR_
CXCR4 Phosphorylation S319 0.861 -0.615 _TSAQHALTS(ph)VSR_
CXCR4 Ubiquitylation K327 0.978 0.329 _GSSLK(gl)ILSK_
GNAI1 Ubiquitylation K92 0.873 0.567 _LK(gl)IDFGDSAR_
GNAQ Ubiquitylation K16 0.245 _TLESIMACCLSEEAK(gl)EAR_
GNAQ Ubiquitylation K102 -0.299 _IPYK(gl)YEHNK_
GNB1 Ubiquitylation K23 -0.282 _K(gl)ACADATLSQITNNIDPVGR_
GNB1 Ubiquitylation K209 -0.296 -0.249 _LFVSGACDASAK(gl)LWDVR_
GNB3 Ubiquitylation K23 -0.282 _K(gl)ACADATLSQITNNIDPVGR_
GNB3 Ubiquitylation K209 -0.296 -0.249 _LFVSGACDASAK(gl)LWDVR_
HRAS Ubiquitylation K170 -1.005 _K(gl)LNPPDESGPGCMSCK_
MAP2K1 Ubiquitylation K192 -0.205 -0.241 _DVK(gl)PSNILVNSR_
MAP2K1 Phosphorylation S385 0.066 _RSDAEEVDFAGWLCSTIGLNQPS(ph)TPTHAAGV_
MAP2K1 Phosphorylation T386 0.377 _RSDAEEVDFAGWLCSTIGLNQPST(ph)PTHAAGV_
MAPK3 Phosphorylation Y204 -0.807 -2.487 _IADPEHDHTGFLTEY(ph)VATR_
MAPK3 Ubiquitylation K289 -0.608 _NYLQSLPSKTK(gl)_
NFKB1 Phosphorylation S907 -0.025 0.113 _TTSQAHSLPLS(ph)PASTR_
PIK3CA Ubiquitylation K864 0.390 0.588 _NSHTIM(ox)QIQCK(gl)GGLK_
PIK3CA Ubiquitylation K868 0.204 0.651 _NSHTIM(ox)QIQCKGGLK(gl)_
PIK3CA Ubiquitylation K974 -0.273 _GAQECTK(gl)TREFER_
PLCG1 Ubiquitylation K300 8.031 _DLK(gl)NMLSQVNYR_
PLCG1 Ubiquitylation K348 -0.219 _SLMYSAQK(gl)TMDLPFLEASTLR_
PLCG1 Ubiquitylation K552 -0.355 _NMAQYFK(gl)K_
PLCG1 Ubiquitylation K553 -0.355 _NMAQYFK(gl)K_
PLCG1 Ubiquitylation K1063 0.864 0.355 _LTEGK(gl)IMER_
PLCG1 Phosphorylation S1370 0.475 0.515 _AREGS(ph)FESR_
PRKCA Phosphorylation S10 -0.650 0.036 _(ac)ADVFPGNDS(ph)TASQDVANR_
PRKCA Phosphorylation S13 -1.038 0.335 _(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCA Phosphorylation S226 0.693 0.415 _STLNPQWNES(ph)FTFK_
PRKCA Ubiquitylation K316 -0.522 -0.535 _LGPAGNK(gl)VISPSEDR_
PRKCB Phosphorylation S10 -0.650 0.036 _(ac)ADVFPGNDS(ph)TASQDVANR_
PRKCB Phosphorylation S13 -1.038 0.335 _(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCB Phosphorylation S226 0.693 0.415 _STLNPQWNES(ph)FTFK_
PRKCB Ubiquitylation K315 0.213 0.518 _ISQGTK(gl)VPEEK_
PXN Phosphorylation S85 -0.156 0.192 _FIHQQPQSSS(ph)PVYGSSAK_
PXN Phosphorylation T136 1.322 _SAEPSPTVMST(ph)SLGSNLSELDR_
PXN Phosphorylation S140 -0.291 -0.948 _SAEPSPTVM(ox)STSLGS(ph)NLSELDR_
PXN Phosphorylation S302 -0.167 _S(ph)SPGGQDEGGFMAQGK_
PXN Phosphorylation S303 -0.167 _S(ph)SPGGQDEGGFMAQGK_
PXN Phosphorylation S322 -1.234 _TGSSS(ph)PPGGPPKPGSQLDSMLGSLQSDLNK_
RAF1 Phosphorylation S29 0.028 -0.571 _DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1 Phosphorylation T31 0.028 -0.669 _DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1 Phosphorylation S244 0.053 _YSTPHAFTFNTSS(ph)PSSEGSLSQR_
RAF1 Phosphorylation S259 -0.069 0.054 _STS(ph)TPNVHM(ox)VSTTLPVDSR_
RAF1 Phosphorylation S301 -0.651 _SHSESASPSALSSSPNNLS(ph)PTGWSQPK_
RAF1 Phosphorylation T303 -0.664 _SHSESASPSALSSSPNNLSPT(ph)GWSQPK_
RAF1 Phosphorylation S497 -0.449 _SRWS(ph)GSQQVEQPTGSVLWMAPEVIR_
RAF1 Phosphorylation S621 0.212 0.271 _SAS(ph)EPSLHR_
RAF1 Phosphorylation S642 -0.197 0.463 _AAHTEDINACTLTTS(ph)PR_


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