bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: PRKCB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKCB 0 2.773 0.260 -0.530
PRKCB 0 2.773 0.260 -0.530 0.349 0.585

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKCB Ubiquitylation K315 0.213 0.518 _ISQGTK(gl)VPEEK_
PRKCB Phosphorylation S226 0.693 0.415 _STLNPQWNES(ph)FTFK_
PRKCB Phosphorylation S13 -1.038 0.335 _(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCB Phosphorylation S10 -0.650 0.036 _(ac)ADVFPGNDS(ph)TASQDVANR_

Background Information for PRKCB:


Pubmed-PRKCB »
Uniprot-PRKCB »
Biogrid-PRKCB »
ProteomicsDB-PRKCB »

Tumorportal-PRKCB »
COSMIC-PRKCB »
GenomeRNAi-PRKCB »
Genecards-PRKCB


Protein-protein Interactions for PRKCB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PRKCA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKCB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members DAG/PE-bd IPR020454 0.18
Category members Kinase-like_dom IPR011009 0.03
Category members C2_dom IPR000008 0
Category members Prot_kinase_dom IPR000719 0
Category members AGC-kinase_C IPR000961 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Protein_kinase_C_a/b/g IPR014375 0
Category members Pkinase_C IPR017892 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PRKCB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PRKCB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042393 histone binding Database 0.94
Category members Pathway Pathway_804 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 0 0.86
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members Pathway Pathway_677 BIOCARTA_MYOSIN_PATHWAY 0 0.53
Category members Pathway Pathway_187 KEGG_VIBRIO_CHOLERAE_INFECTION 0 0.44
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members Pathway Pathway_228 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 0 0.24
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_428 PID_THROMBIN_PAR1_PATHWAY 0 0.18
Category members Pathway Pathway_1011 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 0 0.18
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members Pathway Pathway_686 BIOCARTA_BCR_PATHWAY 0 0.16
Category members Pathway Pathway_685 PID_RAS_PATHWAY 0 0.14
Category members Pathway Pathway_1067 BIOCARTA_CBL_PATHWAY 0 0.14
Category members Pathway Pathway_1155 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 0 0.13
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Database 0.12
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members Pathway Pathway_698 BIOCARTA_CALCINEURIN_PATHWAY 0 0.11
Category members Pathway Pathway_525 BIOCARTA_CXCR4_PATHWAY 0 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0004697 protein kinase C activity Database 0.09
Category members Pathway Pathway_578 BIOCARTA_EGF_PATHWAY 0 0.09
Category members Pathway Pathway_584 BIOCARTA_TPO_PATHWAY 0 0.08
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members Pathway Pathway_1029 BIOCARTA_SRCRPTP_PATHWAY 0 0.08
Category members Pathway Pathway_1003 PID_TCR_RAS_PATHWAY 0 0.05
Category members Pathway Pathway_680 BIOCARTA_SPPA_PATHWAY 0 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_523 BIOCARTA_CCR3_PATHWAY 0 0.04
Category members Pathway Pathway_1059 PID_TCR_JNK_PATHWAY 0 0.04
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members Pathway Pathway_690 BIOCARTA_CCR5_PATHWAY 0 0.03
Category members Pathway Pathway_630 BIOCARTA_PDGF_PATHWAY 0 0.03
Category members Pathway Pathway_663 PID_IL8_CXCR1_PATHWAY 0 0.01
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1094 BIOCARTA_ARENRF2_PATHWAY 0 0
Category members Pathway Pathway_1144 BIOCARTA_MEF2D_PATHWAY 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_176 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0 0
Category members Pathway Pathway_216 BIOCARTA_EDG1_PATHWAY 0 0
Category members Pathway Pathway_218 BIOCARTA_GPCR_PATHWAY 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_234 PID_ENDOTHELIN_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_249 BIOCARTA_CREB_PATHWAY 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_421 BIOCARTA_NOS1_PATHWAY 0 0
Category members Pathway Pathway_424 KEGG_LEISHMANIA_INFECTION 0 0
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members Pathway Pathway_436 KEGG_VEGF_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_556 BIOCARTA_TRKA_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_597 BIOCARTA_FCER1_PATHWAY 0 0
Category members Pathway Pathway_616 BIOCARTA_GH_PATHWAY 0 0
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_682 BIOCARTA_CDMAC_PATHWAY 0 0
Category members Pathway Pathway_691 BIOCARTA_CARDIACEGF_PATHWAY 0 0
Category members Pathway Pathway_693 BIOCARTA_PYK2_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_897 PID_CD8_TCR_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_993 BIOCARTA_AGPCR_PATHWAY 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members GO Category GO:0005246 calcium channel regulator activity Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0010829 negative regulation of glucose transport Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0035403 histone kinase activity (H3-T6 specific) Database 0
Category members GO Category GO:0035408 histone H3-T6 phosphorylation Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0042113 B cell activation Database 0
Category members GO Category GO:0042953 lipoprotein transport Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0
Category members GO Category GO:0050853 B cell receptor signaling pathway Database 0
Category members GO Category GO:0050861 positive regulation of B cell receptor signaling pathway Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0071322 cellular response to carbohydrate stimulus Database 0


.

© Copyright Svejstrup Laboratory 2015