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PID_RAS_PATHWAY
(Pathway_685)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
CAMK2B 1 1.200 -0.790
CAMK2B 1 1.200 -0.790 -0.654 0.073
CAMK2B 1 1.200 -0.790 -0.619 0.544 0.125
CAMK2B 1 1.200 -0.790 0.559 1.698
KRAS 1 -0.510 0.620 1.031 0.887
KRAS 1 -0.510 0.620 0.246 -0.346
NRAS 1 1.810 -0.720 0.246 -0.346
PRKCZ 0 -0.290 0.310
SOS1 0 0.500 -0.620 -0.570
LGALS3 0 0.430 -0.510 -0.143 -1.425
PLCE1 0 0.540 -0.070
RASGRP3 0 0.570 0.240
PRKCA 0 0.750 -0.690 0.349 0.585
PRKCA 0 0.750 -0.690
RABGEF1 0 0.010 0.630
PRKCB 0 0.260 -0.530
PRKCB 0 0.260 -0.530 0.349 0.585
HRAS 0 1.470 -0.520
GRB2 0 -0.240 0.300 -1.021 0.057 0.906
NF1 0 1.000 -0.500 0.444 -0.190

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CAMK2B Ubiquitylation K147 -1.064 _DLKPENLLLASK(gl)CK_
CAMK2B Ubiquitylation K251 -0.437 _DLINK(gl)MLTINPAK_
GRB2 Ubiquitylation K10 0.146 _YDFK(gl)ATADDELSFK_
GRB2 Ubiquitylation K20 -0.078 _ATADDELSFK(gl)R_
GRB2 Ubiquitylation K69 -0.362 0.641 _AK(gl)AEEMLSK_
GRB2 Ubiquitylation K76 0.754 _AEEMLSK(gl)QR_
GRB2 Ubiquitylation K109 0.381 -0.002 _FGNDVQHFK(gl)VLR_
HRAS Ubiquitylation K170 -1.005 _K(gl)LNPPDESGPGCMSCK_
KRAS Ubiquitylation K128 1.528 1.433 _TVDTK(gl)QAHELAK_
KRAS Ubiquitylation K235 0.591 0.087 _TVDTK(gl)QAQDLAR_
KRAS Ubiquitylation K254 -0.450 -0.156 _SYGIPFIETSAK(gl)TR_
NF1 Ubiquitylation K471 0.218 _MAPSLTFKEK(gl)_
NF1 Phosphorylation S864 -0.458 _SNSGLATYS(ph)PPMGPVSER_
NF1 Phosphorylation T2514 0.076 _GSEGYLAATYPTVGQT(ph)SPR_
NF1 Phosphorylation S2515 0.071 0.316 _GSEGYLAATYPTVGQTS(ph)PR_
NF1 Phosphorylation S2543 0.698 0.655 _S(ph)FDHLISDTK_
NRAS Ubiquitylation K128 1.528 1.433 _TVDTK(gl)QAHELAK_
PLCE1 Phosphorylation S1096 -0.120 0.294 _GES(ph)GEVTDDEMATR_
PRKCA Phosphorylation S10 -0.650 0.036 _(ac)ADVFPGNDS(ph)TASQDVANR_
PRKCA Phosphorylation S13 -1.038 0.335 _(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCA Phosphorylation S226 0.693 0.415 _STLNPQWNES(ph)FTFK_
PRKCA Ubiquitylation K316 -0.522 -0.535 _LGPAGNK(gl)VISPSEDR_
PRKCB Phosphorylation S10 -0.650 0.036 _(ac)ADVFPGNDS(ph)TASQDVANR_
PRKCB Phosphorylation S13 -1.038 0.335 _(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCB Phosphorylation S226 0.693 0.415 _STLNPQWNES(ph)FTFK_
PRKCB Ubiquitylation K315 0.213 0.518 _ISQGTK(gl)VPEEK_
PRKCZ Phosphorylation T560 -0.884 -1.578 _KQALPPFQPQITDDYGLDNFDTQFTSEPVQLT(ph)PDDEDAIKR_
RABGEF1 Ubiquitylation K263 -0.601 0.398 _LQREEEEAFASSQSSQGAQSLTFSK(gl)FEEK_
RABGEF1 Ubiquitylation K281 0.077 0.349 _K(gl)FFSASSR_
RABGEF1 Ubiquitylation K292 -1.150 _VGSK(gl)KEIQEAK_
RABGEF1 Ubiquitylation K293 -0.236 0.148 _VGSKK(gl)EIQEAK_
RABGEF1 Ubiquitylation K299 -1.563 -0.828 _EIQEAK(gl)APSPSINR_
RABGEF1 Ubiquitylation K329 -0.156 _TFHK(gl)TGQEIYK_
RABGEF1 Ubiquitylation K336 0.080 _TGQEIYK(gl)QTK_
RABGEF1 Ubiquitylation K457 -0.737 _DLAIQK(gl)R_
RASGRP3 Phosphorylation S390 0.183 0.695 _SPTS(ph)PTTPNK_
SOS1 Phosphorylation S1082 0.278 _IPESETESTASAPNS(ph)PR_
SOS1 Phosphorylation S1166 0.097 -0.094 _RPESAPAES(ph)SPSK_


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