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Query: NF1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NF1 0 1.825 1.000 -0.500 0.444 -0.190

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NF1 Phosphorylation S2543 0.698 0.655 _S(ph)FDHLISDTK_
NF1 Phosphorylation S2515 0.071 0.316 _GSEGYLAATYPTVGQTS(ph)PR_
NF1 Ubiquitylation K471 0.218 _MAPSLTFKEK(gl)_
NF1 Phosphorylation T2514 0.076 _GSEGYLAATYPTVGQT(ph)SPR_
NF1 Phosphorylation S864 -0.458 _SNSGLATYS(ph)PPMGPVSER_

Background Information for NF1:


Pubmed-NF1 »
Uniprot-NF1 »
Biogrid-NF1 »
ProteomicsDB-NF1 »

Tumorportal-NF1 »
COSMIC-NF1 »
GenomeRNAi-NF1 »
Genecards-NF1


Protein-protein Interactions for NF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CA14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPHA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM174A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCN3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFSF13B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members RasGAP IPR001936 0.19
Category members CRAL-TRIO_dom IPR001251 0


Protein complexes (CORUM database) featuring NF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0043409 negative regulation of MAPK cascade Database 0.87
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0014044 Schwann cell development Database 0.62
Category members GO Category GO:0030325 adrenal gland development Database 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members GO Category GO:0022011 myelination in peripheral nervous system Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Disease phenotype COLORECTAL_CANCER COLORECTAL CANCER Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0032320 positive regulation of Ras GTPase activity Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members GO Category GO:0045765 regulation of angiogenesis Database 0.24
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0046580 negative regulation of Ras protein signal transduction Database 0.23
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members GO Category GO:0032228 regulation of synaptic transmission, GABAergic Database 0.19
Category members GO Category GO:0046929 negative regulation of neurotransmitter secretion Database 0.17
Category members Pathway Pathway_685 PID_RAS_PATHWAY 0 0.14
Category members GO Category GO:0050890 cognition Database 0.11
Category members GO Category GO:0001952 regulation of cell-matrix adhesion Database 0.11
Category members Disease phenotype Juvenile_myelomonocytic_leukemia Juvenile myelomonocytic leukemia Database 0.08
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members Pathway Pathway_39 PID_HNF3B_PATHWAY 0 0.08
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0048853 forebrain morphogenesis Database 0.04
Category members Disease phenotype 17q11_microdeletion_syndrome 17q11 microdeletion syndrome Database 0.04
Category members GO Category GO:0021915 neural tube development Database 0.03
Category members GO Category GO:0005099 Ras GTPase activator activity Database 0.02
Category members GO Category GO:0030199 collagen fibril organization Database 0.01
Category members GO Category GO:0001656 metanephros development Database 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Disease phenotype Neurofibromatosis-Noonan_syndrome Neurofibromatosis-Noonan syndrome Database 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001937 negative regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0001953 negative regulation of cell-matrix adhesion Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0007154 cell communication Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0007406 negative regulation of neuroblast proliferation Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007422 peripheral nervous system development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007519 skeletal muscle tissue development Database 0
Category members GO Category GO:0008429 phosphatidylethanolamine binding Database 0
Category members GO Category GO:0008542 visual learning Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0014065 phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0016525 negative regulation of angiogenesis Database 0
Category members GO Category GO:0021510 spinal cord development Database 0
Category members GO Category GO:0031210 phosphatidylcholine binding Database 0
Category members GO Category GO:0031235 intrinsic to cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0035021 negative regulation of Rac protein signal transduction Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0042992 negative regulation of transcription factor import into nucleus Database 0
Category members GO Category GO:0043407 negative regulation of MAP kinase activity Database 0
Category members GO Category GO:0043473 pigmentation Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0043535 regulation of blood vessel endothelial cell migration Database 0
Category members GO Category GO:0045124 regulation of bone resorption Database 0
Category members GO Category GO:0045671 negative regulation of osteoclast differentiation Database 0
Category members GO Category GO:0045762 positive regulation of adenylate cyclase activity Database 0
Category members GO Category GO:0048147 negative regulation of fibroblast proliferation Database 0
Category members GO Category GO:0048169 regulation of long-term neuronal synaptic plasticity Database 0
Category members GO Category GO:0048485 sympathetic nervous system development Database 0
Category members GO Category GO:0048593 camera-type eye morphogenesis Database 0
Category members GO Category GO:0048712 negative regulation of astrocyte differentiation Database 0
Category members GO Category GO:0048715 negative regulation of oligodendrocyte differentiation Database 0
Category members GO Category GO:0048745 smooth muscle tissue development Database 0
Category members GO Category GO:0048844 artery morphogenesis Database 0


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