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The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014).
(pubmedid:24460190)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
XPC 3 -0.140 0.000 2.695 0.925
DDB1 3 -1.620 2.560 0.925 1.008 1.640 0.761 0.768
ERCC2 2 -0.590 1.060 -0.491 1.066
ERCC3 2 -1.110 1.490 2.619 2.418 0.499
STK19 2 -2.520 5.040 3.354
GNA11 1 2.030 -1.240 0.953 0.764 0.108
PRKAR1A 1 -0.550 0.230
PRKAR1A 1 -0.550 0.230
ARID1A 1 0.360 -0.350 0.683 0.272 0.870 -0.131 0.043
ERCC5 1 -2.410 5.420
NRAS 1 1.810 -0.720 0.246 -0.346
ARID1B 0 1.330 -0.340 0.410 -0.553 0.164 0.200
EZH2 0 1.100 -0.960 0.524 0.464 -0.045
SF3B1 0 0.308 -0.445 -0.096 -0.608 -0.188
STK11 0
PPP6C 0 0.340 -0.620 0.715 -0.944 -0.116 0.577
SMARCA4 0 -0.810 1.520 0.629 -0.158 0.141 0.337 0.333
CDK4 0 1.930 -0.950
CDK4 0 1.930 -0.950 -0.510 0.013
RAC1 0 -0.580 1.580 0.486 -0.364 -0.568
TP53 0 -1.070 1.050 -2.808 0.076 -0.094 0.436 0.497
CDKN2A 0 -0.080 -0.260 -0.556 -1.080 -3.270 -1.110
GNAQ 0 0.140 -0.310 0.052 0.449
BRAF 0
BAP1 0 -0.249
WRN 0 -0.320 -0.170 0.180
CTNNB1 0 0.490 -0.230
CTNNB1 0 0.490 -0.230 -0.415 0.628 0.215
POLH 0
HRAS 0 1.470 -0.520
ERCC4 0 1.257
PTPN11 0 -0.210 -0.400 0.644 1.053 0.451
ARID2 0 0.220 -0.610 0.713 -0.130 0.978 0.294 0.323
NF1 0 1.000 -0.500 0.444 -0.190

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ARID1A Phosphorylation S363 0.211 0.022 _SHHAPM(ox)S(ph)PGSSGGGGQPLAR_
ARID1A Phosphorylation S367 -0.142 _SHHAPMSPGSS(ph)GGGGQPLAR_
ARID1A Phosphorylation S381 0.335 _TPQPS(ph)SPMDQMGK_
ARID1A Phosphorylation S382 1.506 0.780 _TPQPSS(ph)PMDQMGK_
ARID1A Phosphorylation S696 -0.934 -0.737 _GPS(ph)PSPVGSPASVAQSR_
ARID1A Phosphorylation S702 0.267 -0.175 _GPS(ph)PSPVGS(ph)PASVAQSR_
ARID1A Phosphorylation S705 0.157 _GPS(ph)PSPVGSPAS(ph)VAQSR_
ARID1A Phosphorylation S772 -0.112 -0.485 _NPQMPQYSSPQPGSALS(ph)PR_
ARID1A Phosphorylation S1182 1.584 1.063 _S(ph)NSVGIQDAFNDGSDSTFQK_
ARID1A Phosphorylation S1184 1.732 1.114 _SNS(ph)VGIQDAFNDGSDSTFQK_
ARID1A Phosphorylation S1754 0.131 -0.654 _VS(ph)SPAPM(ox)EGGEEEEELLGPK_
ARID1A Phosphorylation S1755 -0.409 -0.587 _VSS(ph)PAPMEGGEEEEELLGPK_
ARID1A Phosphorylation S1944 -0.489 _FPFGIS(ph)PAQSHR_
ARID1B Phosphorylation S1555 -0.906 _MS(ph)PSKSPFLPSMK_
ARID2 Ubiquitylation K7 0.027 _(ac)ANSTGK(gl)APPDER_
ARID2 Ubiquitylation K581 0.093 _TVFPNHTVK(gl)R_
ARID2 Phosphorylation S689 -0.677 -1.105 _IPQNPS(ph)PHTHQQQNAPVTVIQSK_
ARID2 Ubiquitylation K1241 0.826 _GDK(gl)IICQK_
BAP1 Phosphorylation S292 0.575 _SASNKS(ph)PLVLEANR_
BAP1 Phosphorylation S325 -0.806 -0.868 _APAASEGNHTDGAEEAAGSCAQAPS(ph)HSPPNKPK_
BAP1 Phosphorylation S327 -1.164 _APAASEGNHTDGAEEAAGSCAQAPSHS(ph)PPNKPK_
BAP1 Phosphorylation T517 -0.361 _SANPT(ph)RPSSPVTSHISK_
BAP1 Phosphorylation S520 0.193 _SANPTRPS(ph)SPVTSHISK_
BAP1 Phosphorylation S521 -0.315 -0.535 _SANPTRPSS(ph)PVTSHISK_
BRAF Phosphorylation S151 -0.685 -0.629 _SNPKS(ph)PQKPIVR_
BRAF Phosphorylation S363 -0.023 -0.241 _S(ph)SSAPNVHINTIEPVNIDDLIR_
BRAF Phosphorylation S365 -0.286 0.012 _SSS(ph)APNVHINTIEPVNIDDLIR_
BRAF Phosphorylation S399 -0.890 -0.527 _GDGGSTTGLS(ph)ATPPASLPGSLTNVK_
BRAF Phosphorylation T401 -0.525 _GDGGSTTGLSAT(ph)PPASLPGSLTNVK_
BRAF Phosphorylation S446 0.246 0.349 _RDS(ph)SDDWEIPDGQITVGQR_
BRAF Phosphorylation S447 0.579 0.623 _RDSS(ph)DDWEIPDGQITVGQR_
BRAF Phosphorylation S729 0.208 0.219 _SAS(ph)EPSLNR_
CDK4 Ubiquitylation K142 -0.552 _DLK(gl)PENILVTSGGTVK_
CDK4 Ubiquitylation K211 -0.101 _K(gl)PLFCGNSEADQLGK_
CDK4 Phosphorylation S236 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK4 Phosphorylation S249 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK4 Ubiquitylation K297 0.247 0.052 _ALQHSYLHK(gl)DEGNPE_
CDK4 Phosphorylation S385 0.649 _HSSIS(ph)PVRLPLNSSLGAELSR_
CDK4 Phosphorylation S420 0.004 -0.202 _ES(ph)KGSPVFLPR_
CDK4 Phosphorylation S423 -0.155 -0.297 _GS(ph)PVFLPR_
CDK4 Phosphorylation T514 0.364 0.570 _DSKPIALKEEIVT(ph)PK_
CDK4 Phosphorylation S681 -2.532 -2.051 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK4 Phosphorylation S685 -2.729 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK4 Phosphorylation T692 -0.765 -1.849 _AIT(ph)PPQQPYK_
CDK4 Phosphorylation S1082 -1.661 -0.980 _KETTSGTSTEPVKNS(ph)SPAPPQPAPGK_
CDK4 Phosphorylation S1083 -1.093 -1.330 _NSS(ph)PAPPQPAPGK_
CDK4 Phosphorylation T1244 -0.956 _RT(ph)PTMPQEEAAACPPHILPPEK_
CTNNB1 Ubiquitylation K158 -1.265 _AIPELTK(gl)LLNDEDQVVVNK_
CTNNB1 Ubiquitylation K180 -0.546 -0.636 _AAVM(ox)VHQLSK(gl)K_
CTNNB1 Ubiquitylation K181 -0.717 -0.729 _AAVMVHQLSKK(gl)_
CTNNB1 Phosphorylation S191 -0.024 0.129 _S(ph)PQMVSAIVR_
CTNNB1 Ubiquitylation K435 -0.350 _NK(gl)MM(ox)VCQVGGIEALVR_
CTNNB1 Ubiquitylation K496 -1.262 _LHYGLPVVVK(gl)_
CTNNB1 Phosphorylation S552 1.233 1.224 _RTS(ph)MGGTQQQFVEGVR_
CTNNB1 Phosphorylation T556 1.275 0.995 _RTSM(ox)GGT(ph)QQQFVEGVR_
CTNNB1 Ubiquitylation K671 -0.941 -0.934 _MSEDKPQDYK(gl)K_
DDB1 Ubiquitylation K150 -0.646 _VIPLDRDNK(gl)ELK_
DDB1 Ubiquitylation K191 0.416 _HVK(gl)TYEVSLR_
DDB1 Ubiquitylation K204 1.756 _EFNK(gl)GPWK_
DDB1 Ubiquitylation K383 0.577 0.094 _QGQGQLVTCSGAFK(gl)EGSLR_
DDB1 Ubiquitylation K484 -0.381 _LVSQEPK(gl)ALVSEWKEPQAK_
DDB1 Ubiquitylation K857 0.452 -0.214 _IVVFQYSDGK(gl)LQTVAEK_
DDB1 Ubiquitylation K1121 -0.339 1.343 _M(ox)QEVVANLQYDDGSGM(ox)K(gl)R_
ERCC2 Ubiquitylation K268 5.973 1.957 _CQGNLETLQK(gl)TVLR_
ERCC2 Ubiquitylation K507 -2.034 _GNDQVAISSK(gl)FETR_
ERCC5 Phosphorylation S766 -0.289 -0.748 _LKTEKEPDATPPS(ph)PR_
ERCC5 Phosphorylation S809 -0.115 0.693 _NAPAAVDEGSIS(ph)PR_
ERCC5 Ubiquitylation K858 0.818 1.193 _INSSTENSDEGLK(gl)VR_
ERCC5 Phosphorylation S951 -0.018 -0.048 _ELTPAS(ph)PTCTNSVSK_
ERCC5 Phosphorylation S988 0.598 1.186 _FDSSLLSS(ph)DDETK_
EZH2 Ubiquitylation K61 0.548 _TEILNQEWK(gl)QR_
EZH2 Phosphorylation S363 0.010 -0.733 _GRLPNNSS(ph)RPSTPTINVLESK_
EZH2 Phosphorylation S366 -0.266 -0.699 _GRLPNNSSRPS(ph)TPTINVLESK_
EZH2 Phosphorylation T367 0.320 -0.372 _LPNNSSRPST(ph)PTINVLESK_
EZH2 Phosphorylation T369 -0.911 _GRLPNNSSRPSTPT(ph)INVLESK_
EZH2 Phosphorylation T487 -0.501 -0.532 _VKESSIIAPAPAEDVDT(ph)PPR_
EZH2 Ubiquitylation K569 -0.974 _AQCNTK(gl)QCPCYLAVR_
EZH2 Ubiquitylation K713 -0.461 _IGIFAK(gl)R_
EZH2 Ubiquitylation K735 0.038 _YSQADALK(gl)YVGIER_
GNA11 Ubiquitylation K16 0.347 _(ac)TLESMMACCLSDEVK(gl)ESKR_
GNA11 Ubiquitylation K27 0.292 1.135 _RINAEIEK(gl)QLR_
GNA11 Ubiquitylation K102 0.502 0.512 _ILYK(gl)YEQNK_
GNAQ Ubiquitylation K16 0.245 _TLESIMACCLSEEAK(gl)EAR_
GNAQ Ubiquitylation K102 -0.299 _IPYK(gl)YEHNK_
HRAS Ubiquitylation K170 -1.005 _K(gl)LNPPDESGPGCMSCK_
NF1 Ubiquitylation K471 0.218 _MAPSLTFKEK(gl)_
NF1 Phosphorylation S864 -0.458 _SNSGLATYS(ph)PPMGPVSER_
NF1 Phosphorylation T2514 0.076 _GSEGYLAATYPTVGQT(ph)SPR_
NF1 Phosphorylation S2515 0.071 0.316 _GSEGYLAATYPTVGQTS(ph)PR_
NF1 Phosphorylation S2543 0.698 0.655 _S(ph)FDHLISDTK_
NRAS Ubiquitylation K128 1.528 1.433 _TVDTK(gl)QAHELAK_
POLH Ubiquitylation K70 -0.166 _SMWADDAKK(gl)_
POLH Ubiquitylation K91 -0.322 _ANLTK(gl)YR_
POLH Ubiquitylation K328 -0.315 _NFPGK(gl)TALATR_
POLH Ubiquitylation K682 -1.530 -1.226 _SFLQPHSSNPQVVSAVSHQGK(gl)R_
PPP6C Ubiquitylation K25 -0.474 _YLPENDLK(gl)R_
PRKAR1A Ubiquitylation K63 -1.895 _LEKEEAK(gl)QIQNLQK_
PRKAR1A Ubiquitylation K70 -0.869 0.073 _QIQNLQK(gl)AGTR_
PRKAR1A Phosphorylation S83 -0.969 -0.776 _EDEIS(ph)PPPPNPVVK_
PRKAR1A Ubiquitylation K92 -3.269 -2.395 _TDSREDEISPPPPNPVVK(gl)GR_
PRKAR1A Ubiquitylation K222 0.412 0.536 _TNVK(gl)LWGIDR_
PRKAR1A Ubiquitylation K244 -0.384 3.721 _K(gl)MYEEFLSK_
PRKAR1A Ubiquitylation K261 -0.886 _VSILESLDK(gl)WER_
PRKAR1A Ubiquitylation K346 0.329 _GPLK(gl)CVK_
PRKAR1A Ubiquitylation K349 -0.425 -0.103 _CVK(gl)LDRPR_
PRKAR1A Ubiquitylation K367 -0.939 0.044 _VLGPCSDILK(gl)R_
PTPN11 Ubiquitylation K124 0.562 _EAEK(gl)LLTEK_
RAC1 Ubiquitylation K115 -1.745 -0.215 _AK(gl)WYPEVR_
RAC1 Ubiquitylation K142 0.492 _LDLRDDK(gl)DTIEK_
RAC1 Ubiquitylation K152 0.099 -0.292 _K(gl)LTPITYPQGLAMAK_
RAC1 Ubiquitylation K166 -0.981 -0.655 _LTPITYPQGLAMAK(gl)EIGAVK_
RAC1 Ubiquitylation K172 1.026 0.412 _EIGAVK(gl)YLECSALTQR_
RAC1 Ubiquitylation K185 -0.113 0.578 _GLK(gl)TVFDEAIR_
RAC1 Ubiquitylation K202 -1.379 -1.447 _AVLCPPPVK(gl)KR_
RAC1 Ubiquitylation K203 -1.708 -1.447 _AVLCPPPVKK(gl)_
SF3B1 Phosphorylation S129 -0.787 -0.713 _TMIIS(ph)PERLDPFADGGK_
SF3B1 Phosphorylation T142 -0.892 -2.157 _TMIIS(ph)PERLDPFADGGKT(ph)PDPK_
SF3B1 Phosphorylation T207 -1.127 -1.868 _WDQTADQT(ph)PGAT(ph)PK_
SF3B1 Phosphorylation T211 -0.765 -1.099 _WDQTADQT(ph)PGAT(ph)PK_
SF3B1 Phosphorylation T223 -0.989 -1.111 _LSSWDQAET(ph)PGHTPSLR_
SF3B1 Phosphorylation T227 -1.216 -0.904 _LSSWDQAETPGHT(ph)PSLR_
SF3B1 Phosphorylation T235 -1.156 _WDET(ph)PGR_
SF3B1 Phosphorylation T273 -0.351 -0.627 _GDT(ph)PGHATPGHGGATSSAR_
SF3B1 Phosphorylation T278 -0.033 -0.482 _GDTPGHAT(ph)PGHGGATSSAR_
SF3B1 Phosphorylation T303 -1.006 _TERDT(ph)PGHGSGWAETPR_
SF3B1 Phosphorylation S308 -0.512 -0.240 _DTPGHGS(ph)GWAETPRTDR_
SF3B1 Phosphorylation T313 -0.638 -0.898 _DTPGHGSGWAET(ph)PR_
SF3B1 Phosphorylation T326 -1.194 -0.893 _GGDSIGET(ph)PT(ph)PGASK_
SF3B1 Phosphorylation T328 -1.194 -1.428 _GGDSIGET(ph)PT(ph)PGASK_
SF3B1 Ubiquitylation K333 -1.360 _GGDSIGETPTPGASK(gl)R_
SF3B1 Phosphorylation S349 -0.947 _SRWDETPASQMGGS(ph)TPVLTPGK_
SF3B1 Phosphorylation T350 -0.911 -0.979 _SRWDETPASQMGGST(ph)PVLTPGK_
SF3B1 Phosphorylation T432 -1.068 -1.330 _KLT(ph)ATPTPLGGM(ox)TGFHM(ox)QTEDR_
SF3B1 Phosphorylation T434 -0.601 -1.311 _LTAT(ph)PTPLGGMTGFHMQTEDR_
SF3B1 Phosphorylation S488 0.467 -0.012 _LLVDVDESTLS(ph)PEEQKER_
SF3B1 Ubiquitylation K793 0.904 0.908 _VVK(gl)QCCGTDGVEANYIK_
SF3B1 Ubiquitylation K963 1.062 0.292 _TAVVMK(gl)TCQEEK_
SF3B1 Ubiquitylation K1014 -0.389 _MTPPIK(gl)DLLPR_
SF3B1 Ubiquitylation K1025 0.848 _LTPILK(gl)NR_
SF3B1 Ubiquitylation K1292 0.731 _IYNDDK(gl)NTYIR_
SMARCA4 Ubiquitylation K357 -0.934 _ITPIQK(gl)PR_
SMARCA4 Ubiquitylation K405 0.109 1.148 _ATIELK(gl)ALR_
SMARCA4 Ubiquitylation K437 -0.317 _DTALETALNAK(gl)AYKR_
SMARCA4 Ubiquitylation K455 0.225 _ITEK(gl)LEK_
SMARCA4 Ubiquitylation K496 0.923 _SVTGK(gl)IQK_
SMARCA4 Phosphorylation S677 -0.880 -0.324 _KAENAEGQTPAIGPDGEPLDETSQMS(ph)DLPVK_
SMARCA4 Ubiquitylation K1283 0.125 _ILAAAK(gl)YK_
SMARCA4 Phosphorylation S1413 -0.265 0.515 _EVDYSDS(ph)LTEK_
SMARCA4 Phosphorylation S1486 -0.713 -0.935 _LS(ph)PNPPNLTK_
STK11 Phosphorylation S31 0.437 0.073 _IDS(ph)TEVIYQPR_
STK11 Phosphorylation T32 1.256 0.248 _IDS(ph)TEVIYQPR_
TP53 Ubiquitylation K120 -0.188 _LGFLHSGTAK(gl)SVTCTYSPALNK_
TP53 Ubiquitylation K164 0.157 -1.260 _AMAIYK(gl)QSQHMTEVVR_
TP53 Phosphorylation S314 -0.695 -1.000 _ALPNNTSS(ph)SPQPK_
TP53 Phosphorylation S315 -0.762 -0.959 _RALPNNTSSS(ph)PQPK_
TP53 Ubiquitylation K320 -0.978 _ALPNNTSSSPQPKK(gl)_
TP53 Ubiquitylation K357 -0.231 -0.823 _ELNEALELKDAQAGK(gl)EPGGSR_
WRN Ubiquitylation K134 0.717 _MLLENKAVK(gl)_
WRN Phosphorylation S1133 0.363 0.023 _SIMVQS(ph)PEK_
XPC Ubiquitylation K81 1.419 0.366 _VTVK(gl)SENLK_
XPC Ubiquitylation K161 1.308 _SLLPVK(gl)PVEIEIETPEQAK_
XPC Ubiquitylation K174 2.462 _SLLPVKPVEIEIETPEQAK(gl)TR_
XPC Ubiquitylation K364 4.366 _TSK(gl)GTKQEETFAK_
XPC Ubiquitylation K367 2.553 2.125 _GTK(gl)QEETFAK_
XPC Ubiquitylation K374 6.783 _QEETFAK(gl)GTCRPSAK_
XPC Ubiquitylation K508 2.971 0.687 _KDPSLPAASSSSSSSK(gl)R_
XPC Ubiquitylation K619 1.753 1.740 _EK(gl)KEDLEFQAK_
XPC Ubiquitylation K650 2.788 -0.207 _NHPLYALK(gl)R_
XPC Ubiquitylation K708 4.328 _MVK(gl)GFSNR_


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