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negative regulation of MAPK cascade
(GO:0043409)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
PSMD10 2 -1.900 3.850 0.390 2.518
IGF1R 1 -0.490 0.750 1.476 0.714
GSTP1 0 -1.460 2.360 0.731 -2.952
CAV1 0 1.150 -0.150
CAV1 0 1.150 -0.150
CAV1 0 1.150 -0.150
DUSP3 0 0.360 -0.500
PPEF2 0
LEMD2 0 0.610 -0.740 0.258 0.433
DAG1 0 0.210 -0.400
NF2 0 -1.080 1.470 0.218 -0.073
NF2 0 -1.080 1.470
NF1 0 1.000 -0.500 0.444 -0.190

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CAV1 Ubiquitylation K5 0.591 0.963 _(ac)SGGK(gl)YVDSEGHLYTVPIR_
CAV1 Phosphorylation S6 0.836 0.688 _(ac)ADELS(ph)EKQVYDAHTK_
CAV1 Ubiquitylation K8 0.244 0.734 _(ac)ADELSEK(gl)QVYDAHTK_
CAV1 Ubiquitylation K26 0.724 0.894 _EQGNIYK(gl)PNNK_
CAV1 Ubiquitylation K30 -0.008 0.317 _EQGNIYKPNNK(gl)AMADELSEK_
CAV1 Ubiquitylation K39 0.690 1.170 _AMADELSEK(gl)QVYDAHTK_
CAV1 Phosphorylation S76 0.607 0.527 _AMADELS(ph)EK_
CAV1 Ubiquitylation K176 -0.259 _INLQK(gl)EI_
DAG1 Ubiquitylation K793 0.843 _LTLEDQATFIK(gl)K_
DAG1 Ubiquitylation K794 0.899 _LTLEDQATFIKK(gl)_
DAG1 Ubiquitylation K881 -0.342 _GSRPK(gl)NMTPYR_
DUSP3 Ubiquitylation K116 -0.586 _AADFIDQALAQK(gl)NGR_
IGF1R Ubiquitylation K47 1.146 _NDYQQLK(gl)R_
IGF1R Ubiquitylation K1033 5.779 _VAIK(gl)TVNEAASMR_
IGF1R Ubiquitylation K1168 0.191 _K(gl)GGKGLLPVR_
IGF1R Ubiquitylation K1171 0.232 _GGK(gl)GLLPVR_
LEMD2 Ubiquitylation K264 0.191 _KTDEFCQAK(gl)QK_
LEMD2 Phosphorylation S497 0.821 _WTKPSS(ph)FSDSER_
LEMD2 Phosphorylation S499 0.833 0.393 _WTKPSSFS(ph)DSER_
LEMD2 Phosphorylation S501 0.450 0.658 _WTKPSSFSDS(ph)ER_
NF1 Ubiquitylation K471 0.218 _MAPSLTFKEK(gl)_
NF1 Phosphorylation S864 -0.458 _SNSGLATYS(ph)PPMGPVSER_
NF1 Phosphorylation T2514 0.076 _GSEGYLAATYPTVGQT(ph)SPR_
NF1 Phosphorylation S2515 0.071 0.316 _GSEGYLAATYPTVGQTS(ph)PR_
NF1 Phosphorylation S2543 0.698 0.655 _S(ph)FDHLISDTK_
NF2 Phosphorylation S13 0.833 0.924 _MSFSS(ph)LKR_
NF2 Phosphorylation S493 1.436 1.115 _RLS(ph)MEIEK_
NF2 Ubiquitylation K586 0.399 -0.041 _LTLQSAK(gl)SR_
PPEF2 Phosphorylation Y466 1.425 _GGGCY(ph)FGPDVTQQLLQKYNMQFLIRS(ph)HECK_
PPEF2 Phosphorylation S487 1.425 _GGGCY(ph)FGPDVTQQLLQKYNMQFLIRS(ph)HECK_
PSMD10 Ubiquitylation K30 0.195 0.473 _LEELKESILADK(gl)SLATR_
PSMD10 Ubiquitylation K221 0.332 _GGLGLILK(gl)R_


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