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Query: DUSP3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DUSP3 0 -0.586 0.360 -0.500

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DUSP3 Ubiquitylation K116 -0.586 _AADFIDQALAQK(gl)NGR_

Background Information for DUSP3:


Pubmed-DUSP3 »
Uniprot-DUSP3 »
Biogrid-DUSP3 »
ProteomicsDB-DUSP3 »

Tumorportal-DUSP3 »
COSMIC-DUSP3 »
GenomeRNAi-DUSP3 »
Genecards-DUSP3


Protein-protein Interactions for DUSP3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARL6IP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf71 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ERLIN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DUSP3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Atypical_DUSP IPR020417 0.23
Category members Atypical_DUSP_famA IPR020405 0.13
Category members Tyr_Pase_rcpt/non-rcpt IPR000242 0
Category members Dual-sp_phosphatase_cat-dom IPR000340 0
Category members Tyr/Dual-sp_Pase IPR000387 0
Category members Dual-sp_phosphatase_subgr_cat IPR020422 0
Category members Prot-tyrosine_phosphatase-like IPR029021 0


Protein complexes (CORUM database) featuring DUSP3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DUSP3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0043409 negative regulation of MAPK cascade Database 0.87
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members Pathway Pathway_1001 REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 0 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0033549 MAP kinase phosphatase activity Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0070373 negative regulation of ERK1 and ERK2 cascade Database 0.1
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members Pathway Pathway_1063 REACTOME_ERK_MAPK_TARGETS 0 0
Category members Pathway Pathway_1064 REACTOME_ERKS_ARE_INACTIVATED 0 0
Category members Pathway Pathway_1065 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0000188 inactivation of MAPK activity Database 0
Category members GO Category GO:0001772 immunological synapse Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0004725 protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0008138 protein tyrosine/serine/threonine phosphatase activity Database 0
Category members GO Category GO:0016311 dephosphorylation Database 0
Category members GO Category GO:0016791 phosphatase activity Database 0
Category members GO Category GO:0035335 peptidyl-tyrosine dephosphorylation Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0046329 negative regulation of JNK cascade Database 0
Category members GO Category GO:0050860 negative regulation of T cell receptor signaling pathway Database 0
Category members GO Category GO:0050868 negative regulation of T cell activation Database 0
Category members GO Category GO:0051403 stress-activated MAPK cascade Database 0


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