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negative regulation of ERK1 and ERK2 cascade
(GO:0070373)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
ANKRD26 1 1.060 -0.760
LYN 1 -1.790 3.770
LYN 1 -1.790 3.770
RPS6KA6 0 -1.250 1.770
GSTP1 0 -1.460 2.360 0.731 -2.952
CSK 0 1.200 -0.960 -1.211
CSK 0 1.200 -0.960
VRK3 0 -0.220 1.020
VRK3 0 -0.220 1.020 0.343 1.144
DUSP3 0 0.360 -0.500
SLC9A3R1 0 0.240 -0.810
PIN1 0 -0.060 -0.440 -1.204 -0.594
ARRB1 0 0.960 -0.620
TNIP1 0 1.510 -0.910
TNIP1 0 1.510 -0.910
CNKSR3 0
FLCN 0 1.070 -0.810
WNK2 0 -0.660 0.130
NDRG2 0 -0.250 0.880
PTPN2 0 1.210 -0.730

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ANKRD26 Phosphorylation S647 0.103 0.567 _ESVNS(ph)PVFGK_
ANKRD26 Ubiquitylation K1607 1.938 _LLVEK(gl)QQSR_
ANKRD26 Ubiquitylation K1674 2.185 _MQQELEK(gl)NITR_
ANKRD26 Ubiquitylation K1722 1.886 _EYVQVLKK(gl)_
ARRB1 Phosphorylation S412 0.138 0.253 _GMKDDKEEEEDGTGS(ph)PQLNNR_
CNKSR3 Phosphorylation S383 0.427 0.709 _GSES(ph)PNSFLDQESR_
CSK Ubiquitylation K196 -0.133 _SGWALNMKELK(gl)_
DUSP3 Ubiquitylation K116 -0.586 _AADFIDQALAQK(gl)NGR_
FLCN Phosphorylation S62 -0.873 -0.905 _AHS(ph)PAEGASVESSSPGPK_
LYN Ubiquitylation K20 -0.592 _GKDSLSDDGVDLK(gl)TQPVR_
LYN Ubiquitylation K40 0.100 _DPTSNK(gl)QQRPVPESQLLPGQR_
LYN Phosphorylation S104 0.944 0.841 _DSLS(ph)DDGVDLK_
LYN Ubiquitylation K213 0.441 _HYQK(gl)QADGLCR_
LYN Ubiquitylation K477 -0.191 _VENCPDELYDIMK(gl)MCWK_
NDRG2 Phosphorylation S328 0.778 -0.121 _S(ph)RTASLTSAASVDGNR_
NDRG2 Phosphorylation S332 0.366 0.448 _TAS(ph)LTSAASVDGNR_
NDRG2 Phosphorylation S338 0.765 -0.768 _TASLTSAAS(ph)VDGNR_
PIN1 Ubiquitylation K13 -0.216 -0.516 _(ac)ADEEKLPPGWEK(gl)R_
PIN1 Ubiquitylation K117 0.117 _SGEEDFESLASQFSDCSSAK(gl)AR_
PTPN2 Phosphorylation S304 -0.873 -0.641 _ELSKEDLSPAFDHS(ph)PNK_
RPS6KA6 Phosphorylation S227 0.363 0.496 _AYS(ph)FCGTVEYM(ox)APEVVNR_
RPS6KA6 Phosphorylation T231 0.315 _KAYSFCGT(ph)VEYMAPEVVNR_
RPS6KA6 Ubiquitylation K566 -0.152 _ICDFGFAK(gl)QLR_
SLC9A3R1 Ubiquitylation K50 -1.732 _LVEPGSPAEK(gl)AGLLAGDR_
SLC9A3R1 Ubiquitylation K101 -2.049 _LLVVDPETDEQLQK(gl)LGVQVR_
SLC9A3R1 Phosphorylation S280 -0.611 -0.277 _EALAEAALES(ph)PRPALVR_
SLC9A3R1 Phosphorylation S290 -0.404 -0.401 _SAS(ph)SDTSEELNSQDSPPK_
TNIP1 Phosphorylation S77 -0.684 _DNELLPPPS(ph)PSLGSFDPLAELTGK_
TNIP1 Ubiquitylation K371 -0.625 _LLLAK(gl)SK_
TNIP1 Ubiquitylation K373 -0.353 _LLLAKSK(gl)_
TNIP1 Phosphorylation S403 0.455 0.424 _YLQDQLS(ph)PLTR_
VRK3 Phosphorylation T58 0.081 _RGLNSSFET(ph)SPKK_
VRK3 Phosphorylation S59 -0.048 0.049 _RGLNSSFETS(ph)PK_
VRK3 Phosphorylation S83 0.463 0.688 _LSLFSDGDSS(ph)ESEDTLSSSER_
WNK2 Phosphorylation S1776 -1.152 _KRPEQQDVS(ph)SPAK_
WNK2 Phosphorylation S1777 -0.593 _KRPEQQDVSS(ph)PAK_


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