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Query: CSK

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CSK 0 -1.344 1.200 -0.960
CSK 0 -1.344 1.200 -0.960 -1.211

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CSK Ubiquitylation K196 -0.133 _SGWALNMKELK(gl)_

Background Information for CSK:


Pubmed-CSK »
Uniprot-CSK »
Biogrid-CSK »
ProteomicsDB-CSK »

Tumorportal-CSK »
COSMIC-CSK »
GenomeRNAi-CSK »
Genecards-CSK


Protein-protein Interactions for CSK
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CSK Cat. description Hein, Mann, Cell 2015


Protein Domains in CSK
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH2 IPR000980 0.05
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members SH3_domain IPR001452 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CSK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CSK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_549 REACTOME_GAB1_SIGNALOSOME 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0070373 negative regulation of ERK1 and ERK2 cascade Database 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1178 BIOCARTA_CELL2CELL_PATHWAY 0 0.08
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members Pathway Pathway_1029 BIOCARTA_SRCRPTP_PATHWAY 0 0.08
Category members GO Category GO:0033673 negative regulation of kinase activity Database 0.07
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0032715 negative regulation of interleukin-6 production Database 0.03
Category members Pathway Pathway_932 REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 0 0.01
Category members GO Category GO:0070064 proline-rich region binding Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1233 REACTOME_PD1_SIGNALING 0 0
Category members Pathway Pathway_1234 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS 0 0
Category members Pathway Pathway_241 BIOCARTA_CSK_PATHWAY 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_515 ST_B_CELL_ANTIGEN_RECEPTOR 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members Pathway Pathway_931 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 0 0
Category members GO Category GO:0004715 non-membrane spanning protein tyrosine kinase activity Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0010989 negative regulation of low-density lipoprotein particle clearance Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0031295 T cell costimulation Database 0
Category members GO Category GO:0034332 adherens junction organization Database 0
Category members GO Category GO:0042997 negative regulation of Golgi to plasma membrane protein transport Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0045779 negative regulation of bone resorption Database 0
Category members GO Category GO:0048709 oligodendrocyte differentiation Database 0
Category members GO Category GO:0050765 negative regulation of phagocytosis Database 0
Category members GO Category GO:0071375 cellular response to peptide hormone stimulus Database 0


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