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Query: ARRB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARRB1 0 0.391 0.960 -0.620

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARRB1 Phosphorylation S412 0.138 0.253 _GMKDDKEEEEDGTGS(ph)PQLNNR_

Background Information for ARRB1:


Pubmed-ARRB1 »
Uniprot-ARRB1 »
Biogrid-ARRB1 »
ProteomicsDB-ARRB1 »

Tumorportal-ARRB1 »
COSMIC-ARRB1 »
GenomeRNAi-ARRB1 »
Genecards-ARRB1


Protein-protein Interactions for ARRB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARRB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARRB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ARRB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Arrestin IPR000698 0
Category members Arrestin-like_N IPR011021 0
Category members Arrestin_C-like IPR011022 0
Category members Ig_E-set IPR014756 0


Protein complexes (CORUM database) featuring ARRB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ARRB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0006892 post-Golgi vesicle-mediated transport Database 0.74
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members GO Category GO:0030659 cytoplasmic vesicle membrane Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0031143 pseudopodium Database 0.46
Category members Pathway Pathway_992 PID_ARF6_PATHWAY 0 0.46
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0051219 phosphoprotein binding Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0006309 apoptotic DNA fragmentation Database 0.26
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members Pathway Pathway_428 PID_THROMBIN_PAR1_PATHWAY 0 0.18
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_473 REACTOME_LYSOSOME_VESICLE_BIOGENESIS 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0070373 negative regulation of ERK1 and ERK2 cascade Database 0.1
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0001933 negative regulation of protein phosphorylation Database 0.04
Category members GO Category GO:0032088 negative regulation of NF-kappaB transcription factor activity Database 0.04
Category members GO Category GO:0032717 negative regulation of interleukin-8 production Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members GO Category GO:0032715 negative regulation of interleukin-6 production Database 0.03
Category members Pathway Pathway_663 PID_IL8_CXCR1_PATHWAY 0 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_217 BIOCARTA_BARRESTIN_PATHWAY 0 0
Category members Pathway Pathway_231 BIOCARTA_BARRESTIN_SRC_PATHWAY 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_264 BIOCARTA_BARR_MAPK_PATHWAY 0 0
Category members Pathway Pathway_655 PID_CXCR3_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_993 BIOCARTA_AGPCR_PATHWAY 0 0
Category members Pathway Pathway_994 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0002031 G-protein coupled receptor internalization Database 0
Category members GO Category GO:0002092 positive regulation of receptor internalization Database 0
Category members GO Category GO:0004857 enzyme inhibitor activity Database 0
Category members GO Category GO:0005159 insulin-like growth factor receptor binding Database 0
Category members GO Category GO:0005834 heterotrimeric G-protein complex Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007602 phototransduction Database 0
Category members GO Category GO:0008277 regulation of G-protein coupled receptor protein signaling pathway Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0030331 estrogen receptor binding Database 0
Category members GO Category GO:0031397 negative regulation of protein ubiquitination Database 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0031434 mitogen-activated protein kinase kinase binding Database 0
Category members GO Category GO:0031691 alpha-1A adrenergic receptor binding Database 0
Category members GO Category GO:0031692 alpha-1B adrenergic receptor binding Database 0
Category members GO Category GO:0031701 angiotensin receptor binding Database 0
Category members GO Category GO:0031762 follicle-stimulating hormone receptor binding Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0034260 negative regulation of GTPase activity Database 0
Category members GO Category GO:0034393 positive regulation of smooth muscle cell apoptotic process Database 0
Category members GO Category GO:0035025 positive regulation of Rho protein signal transduction Database 0
Category members GO Category GO:0035066 positive regulation of histone acetylation Database 0
Category members GO Category GO:0035612 AP-2 adaptor complex binding Database 0
Category members GO Category GO:0035615 clathrin adaptor activity Database 0
Category members GO Category GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus Database 0
Category members GO Category GO:0042699 follicle-stimulating hormone signaling pathway Database 0
Category members GO Category GO:0043149 stress fiber assembly Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0045309 protein phosphorylated amino acid binding Database 0


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