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Query: VRK3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VRK3 0 3.658 -0.220 1.020
VRK3 0 3.658 -0.220 1.020 0.343 1.144

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VRK3 Phosphorylation S83 0.463 0.688 _LSLFSDGDSS(ph)ESEDTLSSSER_
VRK3 Phosphorylation T58 0.081 _RGLNSSFET(ph)SPKK_
VRK3 Phosphorylation S59 -0.048 0.049 _RGLNSSFETS(ph)PK_

Background Information for VRK3:


Pubmed-VRK3 »
Uniprot-VRK3 »
Biogrid-VRK3 »
ProteomicsDB-VRK3 »

Tumorportal-VRK3 »
COSMIC-VRK3 »
GenomeRNAi-VRK3 »
Genecards-VRK3


Protein-protein Interactions for VRK3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NR2E1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNDC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF524 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VRK3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0


Protein complexes (CORUM database) featuring VRK3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring VRK3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0070373 negative regulation of ERK1 and ERK2 cascade Database 0.1
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0032516 positive regulation of phosphoprotein phosphatase activity Database 0


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