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Query: PIN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PIN1 0 -2.197 -0.060 -0.440 -1.204 -0.594

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PIN1 Ubiquitylation K13 -0.216 -0.516 _(ac)ADEEKLPPGWEK(gl)R_
PIN1 Ubiquitylation K117 0.117 _SGEEDFESLASQFSDCSSAK(gl)AR_

Background Information for PIN1:


Pubmed-PIN1 »
Uniprot-PIN1 »
Biogrid-PIN1 »
ProteomicsDB-PIN1 »

Tumorportal-PIN1 »
COSMIC-PIN1 »
GenomeRNAi-PIN1 »
Genecards-PIN1


Protein-protein Interactions for PIN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PIN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WW_dom IPR001202 1.15
Category members PPIase_PpiC IPR000297 0


Protein complexes (CORUM database) featuring PIN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1306 PIN1-AUF1 complex Database 0
Category members Corum 5211 RAF1-PPP2-PIN1 complex Database 0


Categories featuring PIN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members GO Category GO:0003755 peptidyl-prolyl cis-trans isomerase activity Database 1.31
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members Pathway Pathway_840 ST_WNT_BETA_CATENIN_PATHWAY 0 0.6
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0016853 isomerase activity Database 0.37
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0000413 protein peptidyl-prolyl isomerization Database 0.25
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_858 PID_MYC_PATHWAY 0 0.17
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0070373 negative regulation of ERK1 and ERK2 cascade Database 0.1
Category members GO Category GO:0050816 phosphothreonine binding Database 0.08
Category members GO Category GO:0007088 regulation of mitosis Database 0.07
Category members Pathway Pathway_236 BIOCARTA_MPR_PATHWAY 0 0.06
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0032465 regulation of cytokinesis Database 0.05
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_785 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING 0 0
Category members GO Category GO:0031434 mitogen-activated protein kinase kinase binding Database 0
Category members GO Category GO:0032321 positive regulation of Rho GTPase activity Database 0
Category members GO Category GO:0032480 negative regulation of type I interferon production Database 0
Category members GO Category GO:0032794 GTPase activating protein binding Database 0
Category members GO Category GO:0050815 phosphoserine binding Database 0
Category members GO Category GO:0051443 positive regulation of ubiquitin-protein ligase activity Database 0
Category members GO Category GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation Database 0


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