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Results for the Category
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS
(Pathway_484)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
RPS27A 4 -1.330 2.560 -0.309 0.131 -0.009
UBA52 3 -1.260 2.180 -0.309 0.131 -0.009
UBA52 3 -1.260 2.180
HMGB1 2 -1.590 3.400 2.856 -1.899 0.030 -0.792
CASP8 1 1.120 -1.090
TRIM25 1 -0.120 -0.240 0.224 -1.159
TRAF2 1 -0.570 0.540
TRAF2 1 -0.570 0.540
TANK 1 0.110 0.120
CREBBP 0 0.840 -0.950 -3.889 -1.071
NFKB2 0 1.750 -0.820
UBE2K 0 -0.480 0.600
CYLD 0 -1.250 2.010
MAVS 0 1.610 -0.380 -1.056 -0.630
MAP3K1 0 0.750 -1.270
EP300 0 -1.210 1.320 -1.089 -1.694 -0.723
RNF125 0 0.020 0.450
IKBKB 0 0.400 0.610
UBE2D3 0 -1.120 1.910 -0.582 -0.725 -0.315
IFIH1 0 1.630 -0.790
TNFAIP3 0 0.760 -0.500
IRF3 0 -0.190 -0.050
PIN1 0 -0.060 -0.440 -1.204 -0.594
TRAF3 0 -1.050 1.040
UBE2D2 0 -0.010 1.100 -0.582 -0.725 -0.315
UBE2D2 0 -0.010 1.100
RIPK1 0 -0.190 0.440
HERC5 0 -0.330 1.710
APP 0 0.100 -0.260 0.285
ATG12 0 -0.150 1.370
TKFC 0 -1.080 1.190
NLRX1 0 -0.720 0.810 -0.012
RELA 0 -1.130 1.600 0.793
PCBP2 0 -0.130 -0.320
PCBP2 0 -0.130 -0.320
PCBP2 0 -0.130 -0.320 -0.835 -0.602 -0.993 -0.725 -0.337
CHUK 0 -0.480

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
APP Ubiquitylation K751 -1.778 -1.280 _HLSK(gl)M(ox)QQNGYENPTYK_
ATG12 Ubiquitylation K116 0.431 _AVGDTPIMK(gl)TK_
ATG12 Ubiquitylation K118 0.431 _AVGDTPIMK(gl)TK_
CASP8 Ubiquitylation K183 1.917 _IINDYEEFSK(gl)ER_
CASP8 Ubiquitylation K461 -2.031 _NMGK(gl)QMPQPTFTLR_
CHUK Ubiquitylation K296 -1.637 _GGPVDLTLK(gl)QPR_
CREBBP Phosphorylation S2093 0.037 0.097 _SIS(ph)PSALQDLLR_
CYLD Ubiquitylation K114 -1.068 0.927 _FSLFK(gl)NR_
EP300 Phosphorylation S1038 -0.672 -0.349 _TEIKEEEDQPSTSATQSS(ph)PAPGQSK_
EP300 Phosphorylation S1726 0.994 0.627 _LGLGLDDESNNQQAAATQS(ph)PGDSRR_
EP300 Phosphorylation S2328 -1.092 0.725 _PQSQPPHSSPS(ph)PR_
HERC5 Ubiquitylation K397 -3.968 _TIPTLNEGTVK(gl)R_
HERC5 Ubiquitylation K406 -1.155 _WIADVETK(gl)R_
HMGB1 Ubiquitylation K50 0.651 _WK(gl)TMSAK_
HMGB1 Ubiquitylation K59 1.001 0.009 _GK(gl)FEDMAK_
HMGB1 Ubiquitylation K114 0.314 _IK(gl)GEHPGLSIGDVAK_
HMGB1 Ubiquitylation K127 0.018 _IKGEHPGLSIGDVAK(gl)K_
HMGB1 Ubiquitylation K128 -0.407 _K(gl)LGEMWNNTAADDKQPYEK_
HMGB1 Ubiquitylation K157 0.850 _YEK(gl)DIAAYR_
IFIH1 Phosphorylation S301 -1.067 _AS(ph)PEPELQLRPYQMEVAQPALEGK_
IKBKB Ubiquitylation K106 0.253 _K(gl)YLNQFENCCGLR_
IKBKB Phosphorylation S672 0.670 0.244 _GPVSGS(ph)PDSMNASR_
IRF3 Phosphorylation S173 -0.663 -1.111 _S(ph)PSLDNPTPFPNLGPSENPLK_
IRF3 Phosphorylation S175 -0.663 -0.661 _S(ph)PSLDNPTPFPNLGPSENPLKR_
IRF3 Ubiquitylation K193 -3.309 -3.157 _SPSLDNPTPFPNLGPSENPLK(gl)R_
MAP3K1 Phosphorylation S292 0.209 _RAPS(ph)PDGFSPYSPEETNR_
MAP3K1 Phosphorylation S506 1.427 _SHDFYSHELS(ph)SPVDSPSSLR_
MAP3K1 Phosphorylation S507 1.436 _SHDFYSHELSS(ph)PVDSPSSLR_
MAP3K1 Phosphorylation S923 0.127 -0.120 _LSAS(ph)SEDISER_
MAVS Phosphorylation S152 0.146 -0.466 _EKEPSYPMPVQETQAPES(ph)PGENSEQALQTLSPR_
MAVS Phosphorylation S165 -0.888 _EKEPSYPMPVQETQAPESPGENSEQALQTLS(ph)PR_
MAVS Phosphorylation S222 1.349 1.006 _GPVS(ph)PSVSFQPLAR_
MAVS Ubiquitylation K362 0.082 _AGMVPSK(gl)VPTSMVLTK_
NFKB2 Ubiquitylation K741 -2.393 _GHTPLDLTCSTK(gl)VK_
NFKB2 Ubiquitylation K743 -0.624 _GHTPLDLTCSTKVK(gl)_
PCBP2 Ubiquitylation K35 0.116 _LLMHGK(gl)EVGSIIGK_
PCBP2 Ubiquitylation K43 -0.219 _EVGSIIGK(gl)KGESVK_
PCBP2 Ubiquitylation K44 0.838 0.772 _EVGSIIGKK(gl)_
PCBP2 Ubiquitylation K127 -0.025 -0.311 _LVVPASQCGSLIGK(gl)GGCK_
PCBP2 Phosphorylation Y182 -0.851 _GVTIPY(ph)RPKPSSSPVIFAGGQDR_
PCBP2 Phosphorylation S187 -1.067 -0.515 _PS(ph)SSPVIFAGGQDR_
PCBP2 Phosphorylation S188 -0.453 -0.085 _PSS(ph)SPVIFAGGQDR_
PCBP2 Phosphorylation S189 -0.396 _PSSS(ph)PVIFAGGQLTK_
PCBP2 Phosphorylation S189 -0.991 -0.649 _PKPSSS(ph)PVIFAGGQDR_
PCBP2 Phosphorylation S272 -0.207 -0.267 _LHQLAM(ox)QQSHFPM(ox)THGNTGFSGIESSS(ph)PEVK_
PCBP2 Ubiquitylation K317 0.274 0.191 _QGAK(gl)INEIR_
PCBP2 Ubiquitylation K330 -0.123 0.488 _QM(ox)SGAQIK(gl)IANPVEGSTDR_
PIN1 Ubiquitylation K13 -0.216 -0.516 _(ac)ADEEKLPPGWEK(gl)R_
PIN1 Ubiquitylation K117 0.117 _SGEEDFESLASQFSDCSSAK(gl)AR_
RIPK1 Ubiquitylation K642 -0.431 _EGIK(gl)GATVGK_
RNF125 Ubiquitylation K66 -0.518 _SCIATSLK(gl)NNK_
RNF125 Ubiquitylation K69 -0.518 _SCIATSLK(gl)NNK_
RNF125 Ubiquitylation K91 -0.097 _AYLPSEGVPATDVAK(gl)R_
RPS27A Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
RPS27A Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
RPS27A Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
RPS27A Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
RPS27A Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
RPS27A Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
RPS27A Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
RPS27A Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
RPS27A Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
RPS27A Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
RPS27A Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
RPS27A Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
RPS27A Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
RPS27A Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_
TANK Ubiquitylation K195 -2.273 0.787 _QEALFK(gl)PQAK_
TANK Ubiquitylation K199 -1.047 _TDKQEALFKPQAK(gl)DDINR_
TANK Ubiquitylation K231 -0.635 1.969 _GLCRDEEDTSFESLSK(gl)FNVK_
TANK Ubiquitylation K308 -0.969 _TTDK(gl)TKPSNLVNTCIR_
TANK Ubiquitylation K310 -0.969 _TTDK(gl)TKPSNLVNTCIR_
TKFC Ubiquitylation K46 -0.703 _SDLDSLK(gl)GR_
TKFC Ubiquitylation K372 -1.810 -1.307 _VAPAEPQEAPDSTAAGGSASK(gl)R_
TNFAIP3 Ubiquitylation K722 0.496 0.176 _ASCK(gl)NILACR_
TRAF2 Phosphorylation T7 -0.822 -1.190 _(ac)AAASVT(ph)PPGSLELLQPGFSK_
TRAF2 Ubiquitylation K27 -0.253 2.194 _TLLGTK(gl)LEAK_
TRAF2 Ubiquitylation K119 0.519 _GTLK(gl)EYESCHEGR_
TRAF2 Ubiquitylation K176 -1.233 1.022 _APCCGADVK(gl)AHHEVCPK_
TRAF2 Ubiquitylation K207 0.147 0.918 _FQDHVK(gl)TCGK_
TRAF2 Ubiquitylation K481 -0.507 0.417 _MEAK(gl)NSYVR_
TRAF3 Ubiquitylation K369 -1.061 -2.137 _VTELESVDK(gl)SAGQVAR_
TRIM25 Phosphorylation S114 -0.310 -0.309 _ASAPS(ph)PNAQVACDHCLK_
TRIM25 Ubiquitylation K453 1.749 _AK(gl)VLETFLAK_
UBA52 Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
UBA52 Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
UBA52 Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
UBA52 Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
UBA52 Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
UBA52 Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
UBA52 Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
UBA52 Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
UBA52 Ubiquitylation K93 0.181 2.418 _YNCDK(gl)MICR_
UBA52 Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
UBA52 Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
UBA52 Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
UBA52 Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
UBA52 Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
UBA52 Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_
UBE2D2 Ubiquitylation K8 0.326 _INK(gl)ELSDLAR_
UBE2D2 Ubiquitylation K8 0.526 _IHK(gl)ELNDLAR_
UBE2D2 Ubiquitylation K101 -0.229 _SQWSPALTISK(gl)_
UBE2D2 Ubiquitylation K128 0.754 _IYK(gl)TDRDK(gl)YNR_
UBE2D2 Ubiquitylation K128 0.918 _IYK(gl)TDREK_
UBE2D2 Ubiquitylation K133 0.005 _IYK(gl)TDRDK(gl)YNR_
UBE2D2 Ubiquitylation K144 0.212 0.074 _EWTQK(gl)YAM_
UBE2D3 Ubiquitylation K8 0.326 _INK(gl)ELSDLAR_
UBE2D3 Ubiquitylation K101 -0.229 _SQWSPALTISK(gl)_
UBE2D3 Ubiquitylation K128 0.754 _IYK(gl)TDRDK(gl)YNR_
UBE2D3 Ubiquitylation K133 0.005 _IYK(gl)TDRDK(gl)YNR_
UBE2D3 Ubiquitylation K144 0.212 0.074 _EWTQK(gl)YAM_
UBE2K Ubiquitylation K14 0.555 _EFK(gl)EVLKSEETSK_
UBE2K Ubiquitylation K72 -0.864 _IPETYPFNPPK(gl)VR_
UBE2K Ubiquitylation K142 -0.490 0.206 _QNPEMFK(gl)QTAR_
UBE2K Phosphorylation S158 -0.740 _LWAHVYAGAPVS(ph)SPEYTK_
UBE2K Ubiquitylation K164 -0.343 _LWAHVYAGAPVSSPEYTK(gl)K_
UBE2K Ubiquitylation K165 0.840 0.850 _K(gl)IENLCAMGFDR_


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