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Query: RELA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RELA 0 2.393 -1.130 1.600 0.793

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for RELA:


Pubmed-RELA »
Uniprot-RELA »
Biogrid-RELA »
ProteomicsDB-RELA »

Tumorportal-RELA »
COSMIC-RELA »
GenomeRNAi-RELA »
Genecards-RELA


Protein-protein Interactions for RELA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NFKBIA Cat. description Hein, Mann, Cell 2015
Category members IP bait BTRC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C4orf6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXW11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFKBIA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFKBIB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NOV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUFIP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait REL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RELB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RELA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members IPT IPR002909 0.11
Category members NF_Rel_Dor IPR000451 0
Category members p53-like_TF_DNA-bd IPR008967 0
Category members RHD IPR011539 0
Category members Ig_E-set IPR014756 0


Protein complexes (CORUM database) featuring RELA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5196 TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) Database 1.67
Category members Corum 5220 CHUK-IQGAP2-AKAP8L-RELA-TNIP2 complex Database 0.4
Category members Corum 5233 TNF-alpha/NF-kappa B signaling complex 5 Database 0.29
Category members Corum 5461 p50-p65 NF(kappa)B-SRC1 complex Database 0.09
Category members Corum 5232 TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) Database 0.09
Category members Corum 3045 hs4 enhancer complex (faster migrating complex) Database 0.06
Category members Corum 5466 IKB(beta)-RELA-cREL complex Database 0.04
Category members Corum 5193 TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) Database 0.03
Category members Corum 1054 ESR1-RELA-BCL3-NCOA3 complex Database 0
Category members Corum 2084 NFKB1-NFKB2-REL-RELA-RELB complex Database 0
Category members Corum 2086 NFKB1-NFKB2-RELA-RELB complex Database 0
Category members Corum 2105 IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) Database 0
Category members Corum 5194 TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) Database 0
Category members Corum 5228 REL-MAP3K8-RELA-TNIP2-PAPOLA complex Database 0
Category members Corum 5230 CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex Database 0
Category members Corum 5464 I(kappa)B(alpha)-NF(kappa)Bp50-NF(kappa)Bp65 complex Database 0
Category members Corum 5465 IKB(epsilon)-RELA-cREL complex Database 0
Category members Corum 5467 IKB(alpha)-RELA-cREL complex Database 0
Category members Corum 5475 MURR1-NF(kappa)Bp65-IKBA complex Database 0
Category members Corum 5492 IKBA-NF(kappa)Bp65-NF(kappa)Bp50 complex Database 0


Categories featuring RELA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members Pathway Pathway_804 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 0 0.86
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_651 BIOCARTA_RAS_PATHWAY 0 0.61
Category members Pathway Pathway_628 BIOCARTA_GSK3_PATHWAY 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members Pathway Pathway_542 BIOCARTA_AKT_PATHWAY 0 0.45
Category members GO Category GO:0010224 response to UV-B Database 0.44
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0006952 defense response Database 0.32
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members GO Category GO:0051059 NF-kappaB binding Database 0.25
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members GO Category GO:0009612 response to mechanical stimulus Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members GO Category GO:0033590 response to cobalamin Database 0.21
Category members Pathway Pathway_1050 BIOCARTA_RNA_PATHWAY 0 0.21
Category members Pathway Pathway_1145 BIOCARTA_EPONFKB_PATHWAY 0 0.2
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members Pathway Pathway_566 BIOCARTA_HCMV_PATHWAY 0 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_427 PID_IL23_PATHWAY 0 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members Pathway Pathway_525 BIOCARTA_CXCR4_PATHWAY 0 0.11
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0032570 response to progesterone Database 0.1
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0042301 phosphate ion binding Database 0.07
Category members GO Category GO:0032495 response to muramyl dipeptide Database 0.06
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members Pathway Pathway_953 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI 0 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members Pathway Pathway_1159 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR 0 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members GO Category GO:0014040 positive regulation of Schwann cell differentiation Database 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members GO Category GO:0071356 cellular response to tumor necrosis factor Database 0.03
Category members GO Category GO:0070555 response to interleukin-1 Database 0.02
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members Pathway Pathway_1047 BIOCARTA_RELA_PATHWAY 0 0.01
Category members GO Category GO:0070301 cellular response to hydrogen peroxide Database 0
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_1044 BIOCARTA_NTHI_PATHWAY 0 0
Category members Pathway Pathway_1045 BIOCARTA_TNFR2_PATHWAY 0 0
Category members Pathway Pathway_1046 BIOCARTA_STRESS_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1049 BIOCARTA_TALL1_PATHWAY 0 0
Category members Pathway Pathway_1051 PID_NFKAPPAB_CANONICAL_PATHWAY 0 0
Category members Pathway Pathway_1054 BIOCARTA_IL1R_PATHWAY 0 0
Category members Pathway Pathway_1055 BIOCARTA_CD40_PATHWAY 0 0
Category members Pathway Pathway_1057 BIOCARTA_NFKB_PATHWAY 0 0
Category members Pathway Pathway_1096 BIOCARTA_RANKL_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_354 KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 0 0
Category members Pathway Pathway_384 BIOCARTA_FREE_PATHWAY 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_423 PID_IL12_2PATHWAY 0 0
Category members Pathway Pathway_424 KEGG_LEISHMANIA_INFECTION 0 0
Category members Pathway Pathway_439 BIOCARTA_GCR_PATHWAY 0 0
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_524 BIOCARTA_FMLP_PATHWAY 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Pathway Pathway_564 PID_AVB3_OPN_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_610 PID_NFKAPPAB_ATYPICAL_PATHWAY 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_618 REACTOME_DOWNSTREAM_TCR_SIGNALING 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_682 BIOCARTA_CDMAC_PATHWAY 0 0
Category members Pathway Pathway_691 BIOCARTA_CARDIACEGF_PATHWAY 0 0
Category members Pathway Pathway_702 BIOCARTA_VIP_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_737 BIOCARTA_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_803 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL 0 0
Category members Pathway Pathway_806 REACTOME_P75NTR_SIGNALS_VIA_NFKB 0 0
Category members Pathway Pathway_882 BIOCARTA_TID_PATHWAY 0 0
Category members Pathway Pathway_902 BIOCARTA_41BB_PATHWAY 0 0
Category members Pathway Pathway_937 BIOCARTA_TOLL_PATHWAY 0 0
Category members Pathway Pathway_954 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 0 0
Category members Pathway Pathway_958 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 0 0
Category members Pathway Pathway_986 PID_CD40_PATHWAY 0 0
Category members GO Category GO:0001942 hair follicle development Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006968 cellular defense response Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009617 response to bacterium Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010035 response to inorganic substance Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0031293 membrane protein intracellular domain proteolysis Database 0
Category members GO Category GO:0032332 positive regulation of chondrocyte differentiation Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0033613 activating transcription factor binding Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0042177 negative regulation of protein catabolic process Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0043200 response to amino acid Database 0
Category members GO Category GO:0043278 response to morphine Database 0
Category members GO Category GO:0045084 positive regulation of interleukin-12 biosynthetic process Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0
Category members GO Category GO:0050727 regulation of inflammatory response Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051591 response to cAMP Database 0
Category members GO Category GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0
Category members GO Category GO:0071222 cellular response to lipopolysaccharide Database 0
Category members GO Category GO:0071347 cellular response to interleukin-1 Database 0


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