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REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION
(Pathway_954)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
HMGB1 2 -1.590 3.400 2.856 -1.899 0.030 -0.792
TRIM25 1 -0.120 -0.240 0.224 -1.159
TRAF2 1 -0.570 0.540
TRAF2 1 -0.570 0.540
NFKB2 0 1.750 -0.820
MAVS 0 1.610 -0.380 -1.056 -0.630
MAP3K1 0 0.750 -1.270
IKBKB 0 0.400 0.610
IFIH1 0 1.630 -0.790
APP 0 0.100 -0.260 0.285
RELA 0 -1.130 1.600 0.793
CHUK 0 -0.480

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
APP Ubiquitylation K751 -1.778 -1.280 _HLSK(gl)M(ox)QQNGYENPTYK_
CHUK Ubiquitylation K296 -1.637 _GGPVDLTLK(gl)QPR_
HMGB1 Ubiquitylation K50 0.651 _WK(gl)TMSAK_
HMGB1 Ubiquitylation K59 1.001 0.009 _GK(gl)FEDMAK_
HMGB1 Ubiquitylation K114 0.314 _IK(gl)GEHPGLSIGDVAK_
HMGB1 Ubiquitylation K127 0.018 _IKGEHPGLSIGDVAK(gl)K_
HMGB1 Ubiquitylation K128 -0.407 _K(gl)LGEMWNNTAADDKQPYEK_
HMGB1 Ubiquitylation K157 0.850 _YEK(gl)DIAAYR_
IFIH1 Phosphorylation S301 -1.067 _AS(ph)PEPELQLRPYQMEVAQPALEGK_
IKBKB Ubiquitylation K106 0.253 _K(gl)YLNQFENCCGLR_
IKBKB Phosphorylation S672 0.670 0.244 _GPVSGS(ph)PDSMNASR_
MAP3K1 Phosphorylation S292 0.209 _RAPS(ph)PDGFSPYSPEETNR_
MAP3K1 Phosphorylation S506 1.427 _SHDFYSHELS(ph)SPVDSPSSLR_
MAP3K1 Phosphorylation S507 1.436 _SHDFYSHELSS(ph)PVDSPSSLR_
MAP3K1 Phosphorylation S923 0.127 -0.120 _LSAS(ph)SEDISER_
MAVS Phosphorylation S152 0.146 -0.466 _EKEPSYPMPVQETQAPES(ph)PGENSEQALQTLSPR_
MAVS Phosphorylation S165 -0.888 _EKEPSYPMPVQETQAPESPGENSEQALQTLS(ph)PR_
MAVS Phosphorylation S222 1.349 1.006 _GPVS(ph)PSVSFQPLAR_
MAVS Ubiquitylation K362 0.082 _AGMVPSK(gl)VPTSMVLTK_
NFKB2 Ubiquitylation K741 -2.393 _GHTPLDLTCSTK(gl)VK_
NFKB2 Ubiquitylation K743 -0.624 _GHTPLDLTCSTKVK(gl)_
TRAF2 Phosphorylation T7 -0.822 -1.190 _(ac)AAASVT(ph)PPGSLELLQPGFSK_
TRAF2 Ubiquitylation K27 -0.253 2.194 _TLLGTK(gl)LEAK_
TRAF2 Ubiquitylation K119 0.519 _GTLK(gl)EYESCHEGR_
TRAF2 Ubiquitylation K176 -1.233 1.022 _APCCGADVK(gl)AHHEVCPK_
TRAF2 Ubiquitylation K207 0.147 0.918 _FQDHVK(gl)TCGK_
TRAF2 Ubiquitylation K481 -0.507 0.417 _MEAK(gl)NSYVR_
TRIM25 Phosphorylation S114 -0.310 -0.309 _ASAPS(ph)PNAQVACDHCLK_
TRIM25 Ubiquitylation K453 1.749 _AK(gl)VLETFLAK_


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