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PID_CERAMIDE_PATHWAY
(Pathway_734)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
CASP8 1 1.120 -1.090
TRAF2 1 -0.570 0.540
TRAF2 1 -0.570 0.540
RAF1 1 2.020 -1.230
EIF2A 1 -0.180 -0.460 -0.199 -1.243 -0.618
AIFM1 1 1.570 0.130 0.210 0.652 -1.014 0.280 0.386
MAP2K1 1 -1.590 2.780
PAWR 1 -0.550 -0.030 0.396 2.290
PDGFA 1 0.190 -0.340 -2.109 1.885
BAD 0 -0.660 1.190
EIF2AK2 0 -1.060 1.180 -0.657 -0.502 0.213 -0.027
MAP2K4 0 -0.300 0.320
TNFRSF1A 0 -0.590 0.470
PRKCZ 0 -0.290 0.310
MAP4K4 0 -0.500 0.030 0.038 0.092 0.062
MAP4K4 0 -0.500 0.030
BAX 0 1.590 -1.170 0.811 0.359
MAP3K1 0 0.750 -1.270
MAPK3 0
ASAH1 0 -0.300 0.340
NFKB1 0 0.720 -0.810
MADD 0 0.620 -1.050
CTSD 0 0.580 -0.790 -0.768 -2.790 -0.655 -1.981
MAP2K2 0 -0.610 0.080
MAP2K2 0 -0.610 0.080
MYC 0 0.170 0.550 -2.443 -0.949 -0.454 -1.290
RIPK1 0 -0.190 0.440
RB1 0 1.180 -1.070 0.429 0.755
RB1 0 1.180 -1.070
KSR1 0 0.100 0.600
AKT1 0 -0.050 0.700
AKT1 0 0.860 -0.040
PRKCD 0 0.250 0.070 0.578 0.427
BCL2 0 0.910 -0.740
CYCS 0 -0.020 -0.350 0.711 0.320
RELA 0 -1.130 1.600 0.793
PRKRA 0 -1.380 2.380 0.767 0.127

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AIFM1 Ubiquitylation K111 1.676 _ISGLGLTPEQKQK(gl)_
AIFM1 Ubiquitylation K518 -0.545 -0.262 _ATAQDNPK(gl)SATEQSGTGIR_
AKT1 Phosphorylation S124 0.252 0.311 _SGS(ph)PSDNSGAEEMEVSLAKPK_
AKT1 Phosphorylation S126 -0.241 _SGSPS(ph)DNSGAEEM(ox)EVSLAK_
AKT1 Ubiquitylation K301 0.988 _EGIK(gl)DGATMK_
ASAH1 Ubiquitylation K461 0.139 _ESLDVYELDAK(gl)QGR_
BAD Phosphorylation S74 -0.904 -0.452 _HS(ph)SYPAGTEDDEGM(ox)GEEPSPFR_
BAD Phosphorylation S75 -0.914 -0.660 _HSS(ph)YPAGTEDDEGMGEEPSPFR_
BAD Phosphorylation S97 0.056 _S(ph)RSAPPNLWAAQR_
BAD Phosphorylation S99 -0.299 0.161 _S(ph)APPNLWAAQR_
BAD Phosphorylation S118 1.277 1.089 _RM(ox)S(ph)DEFVDSFKK_
BAX Ubiquitylation K57 -1.174 _MGGEAPELALDPVPQDASTK(gl)K_
BAX Ubiquitylation K58 -1.718 -1.174 _MGGEAPELALDPVPQDASTKK(gl)_
BAX Ubiquitylation K64 0.708 1.306 _LSECLK(gl)R_
BCL2 Ubiquitylation K22 1.480 _YIHYK(gl)LSQR_
CASP8 Ubiquitylation K183 1.917 _IINDYEEFSK(gl)ER_
CASP8 Ubiquitylation K461 -2.031 _NMGK(gl)QMPQPTFTLR_
CYCS Ubiquitylation K40 -2.265 _K(gl)TGQAPGYSYTAANK(gl)NK_
CYCS Ubiquitylation K54 -0.872 -1.922 _K(gl)TGQAPGYSYTAANK(gl)NK_
CYCS Ubiquitylation K56 -0.872 -1.922 _TGQAPGYSYTAANKNK(gl)_
CYCS Ubiquitylation K101 -1.859 _ADLIAYLKK(gl)_
EIF2A Ubiquitylation K40 7.150 _NCK(gl)VCIFSK_
EIF2A Phosphorylation S503 -0.843 -0.645 _S(ph)DKSPDLAPTPAPQSTPR_
EIF2A Phosphorylation S506 -0.882 -0.939 _SDKS(ph)PDLAPTPAPQSTPR_
EIF2AK2 Phosphorylation S83 0.256 _KAVS(ph)PLLLTTTNSSEGLSMGNYIGLINR_
KSR1 Phosphorylation S334 0.052 _FDLSHGS(ph)PQMVR_
KSR1 Phosphorylation S406 -0.052 -0.067 _RTES(ph)VPSDINNPVDR_
KSR1 Phosphorylation S569 -0.413 -0.383 _ADVLEAHEAEAEEPEAGKS(ph)EAEDDEDEVDDLPSSR_
MADD Phosphorylation S1059 0.390 0.618 _KRS(ph)PTESVNTPVGK_
MADD Phosphorylation T1061 0.390 0.682 _KRS(ph)PTESVNTPVGK_
MADD Phosphorylation T1237 -0.523 -0.591 _GT(ph)LSDSEIETNSATSTIFGK_
MADD Phosphorylation S1239 0.070 -0.211 _GTLS(ph)DSEIETNSATSTIFGK_
MAP2K1 Ubiquitylation K192 -0.205 -0.241 _DVK(gl)PSNILVNSR_
MAP2K1 Phosphorylation S385 0.066 _RSDAEEVDFAGWLCSTIGLNQPS(ph)TPTHAAGV_
MAP2K1 Phosphorylation T386 0.377 _RSDAEEVDFAGWLCSTIGLNQPST(ph)PTHAAGV_
MAP2K2 Phosphorylation S23 0.873 0.258 _RKPVLPALTINPTIAEGPS(ph)PTSEGASEANLVDLQK_
MAP2K2 Phosphorylation T25 0.439 _RKPVLPALTINPTIAEGPSPT(ph)SEGASEANLVDLQK_
MAP2K2 Ubiquitylation K192 -0.205 -0.241 _DVK(gl)PSNILVNSR_
MAP2K2 Phosphorylation S293 -0.361 _ELEAIFGRPVVDGEEGEPHS(ph)ISPR_
MAP2K2 Phosphorylation S295 -0.234 0.026 _ELEAIFGRPVVDGEEGEPHSIS(ph)PR_
MAP2K2 Phosphorylation T394 0.570 0.158 _LNQPGT(ph)PTR_
MAP2K4 Phosphorylation S80 0.441 _LRTHS(ph)IESSGK_
MAP3K1 Phosphorylation S292 0.209 _RAPS(ph)PDGFSPYSPEETNR_
MAP3K1 Phosphorylation S506 1.427 _SHDFYSHELS(ph)SPVDSPSSLR_
MAP3K1 Phosphorylation S507 1.436 _SHDFYSHELSS(ph)PVDSPSSLR_
MAP3K1 Phosphorylation S923 0.127 -0.120 _LSAS(ph)SEDISER_
MAP4K4 Phosphorylation T704 0.480 0.190 _T(ph)TSRSPVLSR_
MAP4K4 Phosphorylation S706 0.353 0.381 _TTS(ph)RSPVLSR_
MAP4K4 Phosphorylation S708 0.247 0.386 _TTSRS(ph)PVLSR_
MAP4K4 Phosphorylation S716 0.989 -0.508 _RDS(ph)PLQGSGQQNSQAGQR_
MAP4K4 Phosphorylation S981 -0.167 -1.787 _KGS(ph)VVNVNPTNTRPQSDTPEIR_
MAPK3 Phosphorylation Y204 -0.807 -2.487 _IADPEHDHTGFLTEY(ph)VATR_
MAPK3 Ubiquitylation K289 -0.608 _NYLQSLPSKTK(gl)_
MYC Phosphorylation S20 -1.444 -1.145 _PLNVS(ph)FTNR_
MYC Phosphorylation T72 -1.699 -1.813 _FELLPT(ph)PPLS(ph)PSRR_
MYC Phosphorylation S76 -1.777 -1.435 _FELLPTPPLS(ph)PSR_
MYC Phosphorylation S81 0.459 _S(ph)GLCSPSYVAVTPFSLR_
MYC Phosphorylation S85 0.199 0.073 _SGLCS(ph)PSYVAVTPFSLR_
MYC Ubiquitylation K162 -2.475 -1.259 _LVSEK(gl)LASYQAAR_
MYC Phosphorylation S295 -0.903 _SESGS(ph)PSAGGHSKPPHSPLVLK_
MYC Phosphorylation S307 -1.486 _SES(ph)GSPSAGGHSKPPHS(ph)PLVLK_
MYC Ubiquitylation K340 -2.449 _VK(gl)LDSVR_
MYC Ubiquitylation K403 -3.432 _DQIPELENNEK(gl)APK_
NFKB1 Phosphorylation S907 -0.025 0.113 _TTSQAHSLPLS(ph)PASTR_
PAWR Ubiquitylation K227 0.632 _YK(gl)STTSVSEEDVSSR_
PAWR Phosphorylation T230 0.494 _STT(ph)SVSEEDVSSR_
PAWR Phosphorylation S231 0.126 _STTS(ph)VSEEDVSSR_
PAWR Phosphorylation S233 0.241 _STTSVS(ph)EEDVSSR_
PRKCD Ubiquitylation K138 -0.141 _SEDEAK(gl)FPTMNR_
PRKCD Ubiquitylation K222 0.185 0.658 _DTIFQK(gl)ER_
PRKCD Phosphorylation S302 -0.240 -0.222 _S(ph)DSASSEPVGIYQGFEK_
PRKCD Phosphorylation S304 0.378 0.289 _RSDS(ph)ASSEPVGIYQGFEK_
PRKCD Phosphorylation S506 -0.213 0.200 _AS(ph)TFCGTPDYIAPEILQGLK_
PRKCD Phosphorylation T507 -0.149 0.240 _AS(ph)TFCGTPDYIAPEILQGLK_
PRKCD Ubiquitylation K641 -2.000 _DYSNFDQEFLNEK(gl)AR_
PRKCD Phosphorylation S645 0.577 0.832 _ARLS(ph)YSDK_
PRKCD Phosphorylation S647 0.886 0.853 _ARLSYS(ph)DK_
PRKCZ Phosphorylation T560 -0.884 -1.578 _KQALPPFQPQITDDYGLDNFDTQFTSEPVQLT(ph)PDDEDAIKR_
PRKRA Phosphorylation S18 0.646 0.502 _EDS(ph)GTFSLGK_
PRKRA Phosphorylation T20 0.658 0.710 _EDSGT(ph)FSLGK_
RAF1 Phosphorylation S29 0.028 -0.571 _DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1 Phosphorylation T31 0.028 -0.669 _DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1 Phosphorylation S244 0.053 _YSTPHAFTFNTSS(ph)PSSEGSLSQR_
RAF1 Phosphorylation S259 -0.069 0.054 _STS(ph)TPNVHM(ox)VSTTLPVDSR_
RAF1 Phosphorylation S301 -0.651 _SHSESASPSALSSSPNNLS(ph)PTGWSQPK_
RAF1 Phosphorylation T303 -0.664 _SHSESASPSALSSSPNNLSPT(ph)GWSQPK_
RAF1 Phosphorylation S497 -0.449 _SRWS(ph)GSQQVEQPTGSVLWMAPEVIR_
RAF1 Phosphorylation S621 0.212 0.271 _SAS(ph)EPSLHR_
RAF1 Phosphorylation S642 -0.197 0.463 _AAHTEDINACTLTTS(ph)PR_
RB1 Phosphorylation S69 -3.602 -3.397 _TAATAAAAAAEPPAPPPPPPPEEDPEQDS(ph)GPEDLPLVR_
RB1 Ubiquitylation K97 -0.546 _LK(gl)IPDHVR_
RB1 Phosphorylation T388 0.005 0.116 _TLQTDSIDSFETQRT(ph)PR_
RB1 Phosphorylation T405 -0.851 -0.901 _KSNLDEEVNVIPPHT(ph)PVR_
RB1 Phosphorylation S820 -0.019 _S(ph)PYKFPSSPLR_
RB1 Ubiquitylation K823 -2.214 _SPYK(gl)FPSSPLR_
RB1 Phosphorylation S827 0.824 0.111 _FPSS(ph)PLR_
RB1 Phosphorylation S839 -0.701 -1.045 _IPGGNIYIS(ph)PLKS(ph)PYK_
RB1 Ubiquitylation K842 -0.751 _IPGGNIYISPLK(gl)SPYK_
RB1 Phosphorylation S843 -0.701 -0.022 _IPGGNIYIS(ph)PLKS(ph)PYK_
RB1 Ubiquitylation K846 -2.084 _SPYK(gl)ISEGLPTPTK_
RB1 Phosphorylation T853 0.039 -0.555 _ISEGLPT(ph)PTKM(ox)T(ph)PR_
RB1 Ubiquitylation K856 -1.350 _ISEGLPTPTK(gl)MTPR_
RB1 Phosphorylation T858 -0.782 0.564 _ISEGLPT(ph)PTKMT(ph)PR_
RB1 Ubiquitylation K879 -0.187 _FQK(gl)INQMVCNSDR_
RIPK1 Ubiquitylation K642 -0.431 _EGIK(gl)GATVGK_
TNFRSF1A Ubiquitylation K242 -0.111 _SK(gl)LYSIVCGK_
TRAF2 Phosphorylation T7 -0.822 -1.190 _(ac)AAASVT(ph)PPGSLELLQPGFSK_
TRAF2 Ubiquitylation K27 -0.253 2.194 _TLLGTK(gl)LEAK_
TRAF2 Ubiquitylation K119 0.519 _GTLK(gl)EYESCHEGR_
TRAF2 Ubiquitylation K176 -1.233 1.022 _APCCGADVK(gl)AHHEVCPK_
TRAF2 Ubiquitylation K207 0.147 0.918 _FQDHVK(gl)TCGK_
TRAF2 Ubiquitylation K481 -0.507 0.417 _MEAK(gl)NSYVR_


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