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Query: PDGFA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PDGFA 1 -0.224 0.190 -0.340 -2.109 1.885

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for PDGFA:


Pubmed-PDGFA »
Uniprot-PDGFA »
Biogrid-PDGFA »
ProteomicsDB-PDGFA »

Tumorportal-PDGFA »
COSMIC-PDGFA »
GenomeRNAi-PDGFA »
Genecards-PDGFA


Protein-protein Interactions for PDGFA
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in PDGFA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cystine-knot_cytokine IPR029034 0.52
Category members PDGF_N IPR006782 0.08
Category members PDGF/VEGF_dom IPR000072 0.06


Protein complexes (CORUM database) featuring PDGFA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PDGFA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0008083 growth factor activity Database 2.34
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0032956 regulation of actin cytoskeleton organization Database 0.33
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0005902 microvillus Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members GO Category GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway Database 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0010512 negative regulation of phosphatidylinositol biosynthetic process Database 0.08
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members Pathway Pathway_630 BIOCARTA_PDGF_PATHWAY 0 0.03
Category members GO Category GO:0005518 collagen binding Database 0.02
Category members Pathway Pathway_216 BIOCARTA_EDG1_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_895 BIOCARTA_INFLAM_PATHWAY 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001775 cell activation Database 0
Category members GO Category GO:0001942 hair follicle development Database 0
Category members GO Category GO:0002053 positive regulation of mesenchymal cell proliferation Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0005161 platelet-derived growth factor receptor binding Database 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009611 response to wounding Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010035 response to inorganic substance Database 0
Category members GO Category GO:0010544 negative regulation of platelet activation Database 0
Category members GO Category GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0014910 regulation of smooth muscle cell migration Database 0
Category members GO Category GO:0030031 cell projection assembly Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0031093 platelet alpha granule lumen Database 0
Category members GO Category GO:0031954 positive regulation of protein autophosphorylation Database 0
Category members GO Category GO:0032355 response to estradiol Database 0
Category members GO Category GO:0032526 response to retinoic acid Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0045740 positive regulation of DNA replication Database 0
Category members GO Category GO:0048008 platelet-derived growth factor receptor signaling pathway Database 0
Category members GO Category GO:0048286 lung alveolus development Database 0
Category members GO Category GO:0048407 platelet-derived growth factor binding Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0050730 regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0050919 negative chemotaxis Database 0
Category members GO Category GO:0051781 positive regulation of cell division Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0


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