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Query: TNFRSF1A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TNFRSF1A 0 0.359 -0.590 0.470

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TNFRSF1A Ubiquitylation K242 -0.111 _SK(gl)LYSIVCGK_

Background Information for TNFRSF1A:


Pubmed-TNFRSF1A »
Uniprot-TNFRSF1A »
Biogrid-TNFRSF1A »
ProteomicsDB-TNFRSF1A »

Tumorportal-TNFRSF1A »
COSMIC-TNFRSF1A »
GenomeRNAi-TNFRSF1A »
Genecards-TNFRSF1A


Protein-protein Interactions for TNFRSF1A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HNRNPD Cat. description Hein, Mann, Cell 2015
Category members IP bait PHAX Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait VWA9 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNFRSF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TNFRSF1A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DEATH-like_dom IPR011029 1.15
Category members Death_domain IPR000488 0.08
Category members TNFR/NGFR_Cys_rich_reg IPR001368 0


Protein complexes (CORUM database) featuring TNFRSF1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5531 Tumor necrosis factor receptor 1 signaling complex Database 0


Categories featuring TNFRSF1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members GO Category GO:0006952 defense response Database 0.32
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_1082 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0.16
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members GO Category GO:0050729 positive regulation of inflammatory response Database 0.08
Category members GO Category GO:0042742 defense response to bacterium Database 0.06
Category members Pathway Pathway_1062 BIOCARTA_PML_PATHWAY 0 0.06
Category members GO Category GO:0006693 prostaglandin metabolic process Database 0.06
Category members GO Category GO:0033160 positive regulation of protein import into nucleus, translocation Database 0.04
Category members Pathway Pathway_1162 BIOCARTA_SODD_PATHWAY 0 0.04
Category members GO Category GO:0032715 negative regulation of interleukin-6 production Database 0.03
Category members Pathway Pathway_1047 BIOCARTA_RELA_PATHWAY 0 0.01
Category members Pathway Pathway_1021 ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0 0
Category members Pathway Pathway_1046 BIOCARTA_STRESS_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1051 PID_NFKAPPAB_CANONICAL_PATHWAY 0 0
Category members Pathway Pathway_1057 BIOCARTA_NFKB_PATHWAY 0 0
Category members Pathway Pathway_1127 SA_MMP_CYTOKINE_CONNECTION 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_737 BIOCARTA_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_882 BIOCARTA_TID_PATHWAY 0 0
Category members Disease phenotype Intermittent_hydrarthrosis Intermittent hydrarthrosis Database 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0005031 tumor necrosis factor-activated receptor activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0009611 response to wounding Database 0
Category members GO Category GO:0009812 flavonoid metabolic process Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0016101 diterpenoid metabolic process Database 0
Category members GO Category GO:0032760 positive regulation of tumor necrosis factor production Database 0
Category members GO Category GO:0033209 tumor necrosis factor-mediated signaling pathway Database 0
Category members GO Category GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein Database 0
Category members GO Category GO:0043120 tumor necrosis factor binding Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0043200 response to amino acid Database 0
Category members GO Category GO:0043279 response to alkaloid Database 0
Category members GO Category GO:0050728 negative regulation of inflammatory response Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0
Category members GO Category GO:0071392 cellular response to estradiol stimulus Database 0


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