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ST_TUMOR_NECROSIS_FACTOR_PATHWAY
(Pathway_1021)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
JUN 3 -0.930 0.930 -0.126
RALBP1 1 -1.890 3.240
CASP8 1 1.120 -1.090
TRAF2 1 -0.570 0.540
TRAF2 1 -0.570 0.540
TONSL 1 -1.900 3.540 -0.261 -3.160 0.665 1.051
AGFG1 1 -1.660 2.550
NR2C2 1 -2.470 4.780
MAP2K4 0 -0.300 0.320
TNFRSF1A 0 -0.590 0.470
NFKB2 0 1.750 -0.820
NFKB1 0 0.720 -0.810
BIRC2 0 -0.730 0.440
BIRC2 0 -0.730 0.440
TNFAIP3 0 0.760 -0.500
MAP3K7 0 -1.120 1.140 -1.048
RIPK1 0 -0.190 0.440
NFKBIE 0 1.270 -0.670
CASP3 0 0.570 -0.390
MAP3K3 0 0.830 -0.050

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AGFG1 Phosphorylation S179 -0.502 _GTPS(ph)QSPVVGR_
AGFG1 Phosphorylation S181 -0.503 -0.338 _GTPSQS(ph)PVVGR_
BIRC2 Ubiquitylation K15 -0.259 0.307 _(ac)MEDSTILSDWTNSNK(gl)QK_
BIRC2 Ubiquitylation K17 -0.259 0.307 _(ac)MEDSTILSDWTNSNK(gl)QK_
BIRC2 Ubiquitylation K38 -0.069 _SIMEDSTILSDWTNSNKQK(gl)_
BIRC2 Ubiquitylation K102 -1.755 _LGDSPIQK(gl)HK_
BIRC2 Ubiquitylation K233 -0.511 _LSNWEPK(gl)DDAMSEHR_
BIRC2 Ubiquitylation K410 0.878 _DLVK(gl)QTVQSK_
BIRC2 Ubiquitylation K490 0.305 0.534 _ANVINK(gl)QEHDIIK_
BIRC2 Ubiquitylation K497 -1.934 _ANVINKQEHDIIK(gl)QK_
CASP3 Ubiquitylation K11 -0.053 -0.687 _(ac)MENTENSVDSK(gl)SIK_
CASP3 Ubiquitylation K14 -0.455 -0.687 _SIK(gl)NLEPK_
CASP3 Ubiquitylation K57 -0.304 -1.817 _NFHK(gl)STGMTSR_
CASP3 Ubiquitylation K82 -0.268 -0.605 _NLK(gl)YEVR_
CASP8 Ubiquitylation K183 1.917 _IINDYEEFSK(gl)ER_
CASP8 Ubiquitylation K461 -2.031 _NMGK(gl)QMPQPTFTLR_
JUN Phosphorylation S58 -0.167 -1.247 _AKNS(ph)DLLTSPDVGLLK_
JUN Phosphorylation T62 2.545 1.674 _NSDLLT(ph)SPDVGLLK_
JUN Phosphorylation S63 2.030 1.458 _NSDLLTS(ph)PDVGLLK_
JUN Ubiquitylation K70 9.213 _NSDLLTSPDVGLLK(gl)_
JUN Phosphorylation S73 1.499 0.845 _LAS(ph)PELER_
JUN Phosphorylation S243 -0.642 -1.399 _LQALKEEPQTVPEMPGETPPLS(ph)PIDMESQER_
JUN Ubiquitylation K309 1.034 0.155 _EQVAQLK(gl)QK_
MAP2K4 Phosphorylation S80 0.441 _LRTHS(ph)IESSGK_
MAP3K3 Phosphorylation S166 -0.325 _HLS(ph)VSSQNPGR_
MAP3K3 Phosphorylation S175 0.120 -0.091 _S(ph)SPPPGYVPER_
MAP3K3 Phosphorylation S176 0.120 -0.091 _S(ph)SPPPGYVPER_
MAP3K3 Phosphorylation S250 -0.070 _AQS(ph)FPDNR_
MAP3K7 Phosphorylation S374 0.149 -0.337 _GS(ph)SVESLPPTSEGK_
MAP3K7 Phosphorylation S375 0.171 -0.087 _GSS(ph)VESLPPTSEGK_
MAP3K7 Phosphorylation S389 1.072 1.445 _RMS(ph)ADMSEIEAR_
MAP3K7 Phosphorylation S439 0.246 0.198 _S(ph)IQDLTVTGTEPGQVSSR_
MAP3K7 Ubiquitylation K474 -0.385 -0.242 _MITTSGPTSEK(gl)PTR_
MAP3K7 Ubiquitylation K589 -0.104 _SLSTYYQQCK(gl)K_
MAP3K7 Ubiquitylation K590 -0.551 0.560 _K(gl)QLEVIR_
NFKB1 Phosphorylation S907 -0.025 0.113 _TTSQAHSLPLS(ph)PASTR_
NFKB2 Ubiquitylation K741 -2.393 _GHTPLDLTCSTK(gl)VK_
NFKB2 Ubiquitylation K743 -0.624 _GHTPLDLTCSTKVK(gl)_
NFKBIE Ubiquitylation K316 -0.248 _ALVLK(gl)GASR_
NR2C2 Ubiquitylation K250 -0.596 _SPLIATPTFVADK(gl)DGAR_
NR2C2 Phosphorylation S370 -0.170 _DQS(ph)TPIIEVEGPLLSDTHVTFK_
NR2C2 Phosphorylation T371 0.442 -0.117 _DQST(ph)PIIEVEGPLLSDTHVTFK_
RALBP1 Phosphorylation S10 -0.478 _(ac)TECFLPPTS(ph)SPSEHR_
RALBP1 Phosphorylation S11 -0.587 -0.381 _(ac)TECFLPPTSS(ph)PSEHRR_
RALBP1 Phosphorylation S13 -0.465 _(ac)TECFLPPTSSPS(ph)EHR_
RALBP1 Phosphorylation S29 -0.625 -1.152 _TPS(ph)SEEISPTK_
RALBP1 Phosphorylation S30 -1.015 _TPSS(ph)EEISPTKFPGLYR_
RALBP1 Phosphorylation S645 -0.718 -0.600 _AGKEPAKPS(ph)PSR_
RIPK1 Ubiquitylation K642 -0.431 _EGIK(gl)GATVGK_
TNFAIP3 Ubiquitylation K722 0.496 0.176 _ASCK(gl)NILACR_
TNFRSF1A Ubiquitylation K242 -0.111 _SK(gl)LYSIVCGK_
TONSL Ubiquitylation K336 -1.432 _AAEAYQK(gl)QLR_
TONSL Phosphorylation S719 -0.359 -0.212 _VS(ph)PGQAAPAMARPR_
TRAF2 Phosphorylation T7 -0.822 -1.190 _(ac)AAASVT(ph)PPGSLELLQPGFSK_
TRAF2 Ubiquitylation K27 -0.253 2.194 _TLLGTK(gl)LEAK_
TRAF2 Ubiquitylation K119 0.519 _GTLK(gl)EYESCHEGR_
TRAF2 Ubiquitylation K176 -1.233 1.022 _APCCGADVK(gl)AHHEVCPK_
TRAF2 Ubiquitylation K207 0.147 0.918 _FQDHVK(gl)TCGK_
TRAF2 Ubiquitylation K481 -0.507 0.417 _MEAK(gl)NSYVR_


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