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Results for the Category
intrinsic apoptotic signaling pathway in response to DNA damage
(GO:0008630)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
ERCC6 4 -1.310 2.800 5.118 1.227 2.135
ERCC6 4 0.480 0.030 5.118 1.227 2.135
ERCC6 4 -1.310 2.800 0.074 0.258
ERCC6 4 0.480 0.030 0.074 0.258
PRKDC 3 1.430 -1.280 -0.994 -0.672 -0.244 0.307 0.443
BRCA1 2 0.200 -0.140 0.433 0.018 0.146
MSH6 2 -0.410 0.140 -0.115 0.232 0.645 0.407 0.101
EI24 2 0.040 -0.170 1.100 0.629
CHEK2 2 0.530 0.100
BAK1 1 0.710 0.160 -0.419 2.039
MSH2 1 -0.130 0.010 0.224 0.457 0.838 0.840 0.366
SOD2 1 -0.340 0.140 2.161 -0.330
PML 1 -0.420 0.350 -0.244 0.322
LYN 1 -1.790 3.770
LYN 1 -1.790 3.770
BAD 0 -0.660 1.190
TNFRSF1A 0 -0.590 0.470
MLH1 0 -0.460 0.110 -0.360 1.227 1.219
BAX 0 1.590 -1.170 0.811 0.359
SIRT1 0 0.910 -0.910
ABL1 0 0.670 -0.070
HMOX1 0 0.330 0.220 -1.817 -1.289
NFATC4 0 0.060 0.210
CASP2 0 0.980 -1.120
UACA 0 -0.200 -0.170 0.298 0.359
PMAIP1 0 0.570 -0.670
EPHA2 0 1.330 -0.460 0.221
MCL1 0 1.740 -0.780 -0.419
IKBKE 0
TBK1 0
PIK3R1 0 1.910 -1.220 -0.441 0.147
ATM 0 0.398 0.474
BCL2L1 0
BCL2 0 0.910 -0.740
SFN 0 0.890 0.120 -4.300
TOPORS 0 0.090 -0.190

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ABL1 Phosphorylation S1083 -1.131 -0.857 _GQGESDPLDHEPAVS(ph)PLLPR_
ABL1 Phosphorylation S1134 0.293 _SSS(ph)FREMDGQPER_
ABL1 Phosphorylation S1232 0.821 0.183 _SCS(ph)ASCVPHGAK_
ATM Ubiquitylation K307 -0.196 _GAYESTK(gl)WR_
ATM Ubiquitylation K331 -0.126 _GK(gl)YSSGFR_
ATM Ubiquitylation K385 -0.669 _ESSDYSVPCK(gl)R_
ATM Ubiquitylation K1101 -0.548 _LFQDTK(gl)GDSSR_
ATM Ubiquitylation K1109 -1.666 _LLK(gl)ALPLK_
ATM Ubiquitylation K1698 -1.026 _DASYTK(gl)ALK_
ATM Ubiquitylation K1738 -0.137 _SAAVTCLK(gl)NILATK_
ATM Ubiquitylation K2025 -1.497 _SIGEPDSLYGCGGGK(gl)MLQPITR_
BAD Phosphorylation S74 -0.904 -0.452 _HS(ph)SYPAGTEDDEGM(ox)GEEPSPFR_
BAD Phosphorylation S75 -0.914 -0.660 _HSS(ph)YPAGTEDDEGMGEEPSPFR_
BAD Phosphorylation S97 0.056 _S(ph)RSAPPNLWAAQR_
BAD Phosphorylation S99 -0.299 0.161 _S(ph)APPNLWAAQR_
BAD Phosphorylation S118 1.277 1.089 _RM(ox)S(ph)DEFVDSFKK_
BAX Ubiquitylation K57 -1.174 _MGGEAPELALDPVPQDASTK(gl)K_
BAX Ubiquitylation K58 -1.718 -1.174 _MGGEAPELALDPVPQDASTKK(gl)_
BAX Ubiquitylation K64 0.708 1.306 _LSECLK(gl)R_
BCL2 Ubiquitylation K22 1.480 _YIHYK(gl)LSQR_
BCL2L1 Ubiquitylation K87 0.026 _EVIPMAAVK(gl)QALR_
BRCA1 Phosphorylation S123 0.465 0.445 _KENNSPEHLKDEVS(ph)IIQSM(ox)GYR_
BRCA1 Phosphorylation S753 2.662 4.077 _VSNNAEDPKDLMLS(ph)GER_
BRCA1 Phosphorylation S1009 0.733 1.028 _KNLLEENFEEHSM(ox)S(ph)PER_
BRCA1 Phosphorylation S1546 1.821 2.105 _NYPS(ph)QEELIK_
BRCA1 Phosphorylation S1564 3.065 _VVDVEEQQLEES(ph)GPHDLTETSYLPR_
BRCA1 Phosphorylation S1664 1.120 _EKPELTAS(ph)TER_
CASP2 Phosphorylation S340 -0.347 -1.529 _NHAGS(ph)PGCEESDAGKEK_
CHEK2 Phosphorylation S260 3.670 3.632 _KFAIGS(ph)AR_
CHEK2 Ubiquitylation K437 -0.826 _TQVSLK(gl)DQITSGK_
EI24 Phosphorylation S46 1.497 0.314 _RAS(ph)SVLAQR_
EI24 Phosphorylation S330 3.730 2.164 _FPSPHPS(ph)PAK_
EPHA2 Ubiquitylation K578 -0.752 -0.618 _QSPEDVYFSK(gl)SEQLKPLK_
EPHA2 Ubiquitylation K583 0.445 0.124 _SEQLK(gl)PLK_
EPHA2 Ubiquitylation K617 0.339 _QK(gl)VIGAGEFGEVYK_
EPHA2 Ubiquitylation K649 -1.219 _TLK(gl)AGYTEK_
EPHA2 Phosphorylation S897 0.000 _LPS(ph)TSGSEGVPFR_
EPHA2 Phosphorylation T898 -0.329 0.424 _LPST(ph)SGSEGVPFR_
ERCC6 Phosphorylation S158 0.039 0.466 _IIEQLS(ph)PQAATSR_
ERCC6 Phosphorylation S212 -0.295 _IELDHAS(ph)LEEDAEPGPSSLGSMLMPVQETAWEELIR_
ERCC6 Ubiquitylation K255 0.184 -1.007 _TGQMTPFGTQIPQK(gl)QEK_
ERCC6 Ubiquitylation K258 0.830 -1.007 _TGQMTPFGTQIPQKQEK(gl)_
ERCC6 Phosphorylation T303 -1.105 _KAPAPVT(ph)PPAPVQNK_
ERCC6 Ubiquitylation K345 0.454 -0.211 _ALQFQGK(gl)VGLPK_
ERCC6 Ubiquitylation K606 0.305 _VAILHETGSYTHK(gl)K_
ERCC6 Ubiquitylation K607 0.278 _VAILHETGSYTHKK(gl)_
ERCC6 Ubiquitylation K663 -0.597 0.145 _NPNAAVTLACK(gl)QFR_
ERCC6 Ubiquitylation K729 1.490 0.510 _TAYK(gl)CACVLR_
ERCC6 Ubiquitylation K759 -0.019 _MSLSLPDK(gl)NEQVLFCR_
ERCC6 Ubiquitylation K774 0.041 1.536 _LTDEQHK(gl)VYQNFVDSK_
ERCC6 Ubiquitylation K783 0.262 -0.019 _VYQNFVDSK(gl)EVYR_
ERCC6 Ubiquitylation K955 -0.048 -0.623 _K(gl)QVTVYR_
ERCC6 Phosphorylation S1068 0.742 0.512 _KFPASNISVNDATS(ph)SEEKSEAK_
ERCC6 Phosphorylation S1142 0.830 0.891 _TSMPS(ph)GDESIDEK_
ERCC6 Phosphorylation S1146 1.367 0.961 _TSMPSGDES(ph)IDEK_
ERCC6 Ubiquitylation K1156 0.818 -0.034 _LGLSYK(gl)R_
ERCC6 Ubiquitylation K1295 0.149 0.443 _VAQDALK(gl)ALR_
ERCC6 Ubiquitylation K1327 -0.793 0.156 _GISGAPAGK(gl)K_
ERCC6 Ubiquitylation K1328 -0.793 0.232 _GISGAPAGKK(gl)_
ERCC6 Phosphorylation S1345 0.486 0.469 _NSNFSVQHPS(ph)STSPTEK_
ERCC6 Phosphorylation S1346 0.052 0.548 _NSNFSVQHPSS(ph)TSPTEK_
ERCC6 Phosphorylation T1347 0.180 0.745 _NSNFSVQHPSST(ph)SPTEK_
ERCC6 Phosphorylation S1348 0.238 0.374 _NSNFSVQHPSSTS(ph)PTEK_
ERCC6 Ubiquitylation K1352 -1.415 _NSNFSVQHPSSTSPTEK(gl)CQDGIMK_
ERCC6 Ubiquitylation K1359 0.923 _CQDGIMK(gl)K_
ERCC6 Ubiquitylation K1360 2.898 _CQDGIMKK(gl)_
ERCC6 Ubiquitylation K1363 -0.116 -0.707 _EGK(gl)DNVPEHFSGR_
ERCC6 Phosphorylation S1379 0.589 0.418 _AEDADS(ph)SSGPLASSSLLAK_
ERCC6 Ubiquitylation K1392 -0.822 -0.293 _AEDADSSSGPLASSSLLAK(gl)MR_
ERCC6 Ubiquitylation K1457 0.602 1.210 _EILQEFESK(gl)LSASQSCVFR_
ERCC6 Ubiquitylation K1487 -0.363 -0.266 _TSGGEGIWK(gl)LKPEYC_
HMOX1 Ubiquitylation K243 -0.972 _ASNK(gl)VQDSAPVETPR_
HMOX1 Ubiquitylation K256 -1.769 _GK(gl)PPLNTR_
IKBKE Ubiquitylation K137 -0.689 _DIK(gl)PGNIMR_
LYN Ubiquitylation K20 -0.592 _GKDSLSDDGVDLK(gl)TQPVR_
LYN Ubiquitylation K40 0.100 _DPTSNK(gl)QQRPVPESQLLPGQR_
LYN Phosphorylation S104 0.944 0.841 _DSLS(ph)DDGVDLK_
LYN Ubiquitylation K213 0.441 _HYQK(gl)QADGLCR_
LYN Ubiquitylation K477 -0.191 _VENCPDELYDIMK(gl)MCWK_
MCL1 Ubiquitylation K40 -0.321 _LLATEK(gl)EASAR_
MCL1 Phosphorylation T163 -1.997 -1.027 _RPAVLPLLELVGESGNNTSTDGSLPST(ph)PPPAEEEEDELYR_
MCL1 Ubiquitylation K194 -1.646 -1.025 _EQATGAK(gl)DTK(gl)PMGR_
MCL1 Ubiquitylation K197 -1.782 -1.165 _EQATGAK(gl)DTK(gl)PMGR_
MCL1 Ubiquitylation K308 -0.687 0.011 _DWLVK(gl)QR_
MSH2 Ubiquitylation K212 -0.233 _ECVLPGGETAGDMGK(gl)LR_
MSH2 Ubiquitylation K249 0.461 _K(gl)GEQMNSAVLPEMENQVAVSSLSAVIK_
MSH2 Ubiquitylation K347 2.867 _LVNQWIK(gl)QPLMDK_
MSH2 Ubiquitylation K531 1.040 _VTCKEEK(gl)VLR_
MSH2 Ubiquitylation K555 0.164 _FTNSK(gl)LTSLNEEYTK_
MSH2 Ubiquitylation K635 -0.376 _IILK(gl)ASR_
MSH6 Phosphorylation S41 -0.708 -0.948 _AAAAPGAS(ph)PSPGGDAAWSEAGPGPRPLAR_
MSH6 Phosphorylation S43 0.319 -0.234 _AAAAPGASPS(ph)PGGDAAWSEAGPGPR_
MSH6 Phosphorylation S137 0.203 0.359 _VHVQFFDDS(ph)PTR_
MSH6 Phosphorylation T139 0.209 _VHVQFFDDSPT(ph)R_
MSH6 Phosphorylation S227 -0.199 -0.192 _SEEDNEIES(ph)EEEVQPK_
MSH6 Ubiquitylation K334 0.193 _QATSISSETK(gl)NTLR_
MSH6 Ubiquitylation K476 1.536 0.184 _YSDSLVQK(gl)GYK_
MSH6 Ubiquitylation K519 2.264 0.186 _IITK(gl)GTQTYSVLEGDPSENYSK_
MSH6 Ubiquitylation K728 0.082 -0.280 _SGAIFTK(gl)AYQR_
MSH6 Ubiquitylation K771 -0.582 -1.069 _VDTCHTPFGK(gl)R_
MSH6 Phosphorylation S830 0.130 1.666 _IHNVGS(ph)PLK_
MSH6 Ubiquitylation K852 -0.044 _AIMYEETTYSK(gl)K_
MSH6 Ubiquitylation K853 -0.044 _AIMYEETTYSK(gl)K_
MSH6 Ubiquitylation K896 -0.342 _QVISLQTK(gl)NPEGR_
MSH6 Ubiquitylation K997 -0.863 _NLPEEYELK(gl)STK_
MSH6 Ubiquitylation K1009 -0.817 _YWTK(gl)TIEK_
MSH6 Ubiquitylation K1030 0.394 -0.156 _DVSLK(gl)DCMR_
MSH6 Ubiquitylation K1240 -0.672 _ELAETIK(gl)CR_
MSH6 Ubiquitylation K1291 0.633 _FIK(gl)GACPK_
MSH6 Ubiquitylation K1296 -1.142 _GACPK(gl)SYGFNAAR_
MSH6 Ubiquitylation K1315 -1.738 _LANLPEEVIQK(gl)GHR_
MSH6 Ubiquitylation K1325 -0.190 _EFEK(gl)MNQSLR_
NFATC4 Phosphorylation S289 -1.594 -0.700 _RGS(ph)LGEEGSEPPPPPPLPLAR_
NFATC4 Phosphorylation S311 0.305 _DPGS(ph)PGPFDYVGAPPAESIPQK_
NFATC4 Phosphorylation S334 0.917 0.074 _RTS(ph)SEQAVALPR_
PMAIP1 Ubiquitylation K35 -1.475 0.286 _RFGDK(gl)LNFR_
PMAIP1 Ubiquitylation K41 -1.597 0.340 _QK(gl)LLNLISK_
PMAIP1 Ubiquitylation K48 -2.007 -0.586 _LLNLISK(gl)_
PML Ubiquitylation K394 0.515 0.360 _LQDLSSCITQGK(gl)DAAVSKK_
PML Phosphorylation S403 3.141 _KAS(ph)PEAASTPRDPIDVDLPEEAER_
PML Ubiquitylation K476 -0.403 -0.735 _GPSYGEDVSNTTTAQK(gl)R_
PML Phosphorylation S504 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Phosphorylation S505 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Phosphorylation S518 -1.632 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_
PML Phosphorylation S527 -1.392 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_
PML Phosphorylation S530 0.466 0.093 _S(ph)PVIGSEVFLPNSNHVASGAGEAEER_
PML Ubiquitylation K623 -0.784 _IDNETQK(gl)ISQLAAVNR_
PRKDC Ubiquitylation K108 0.568 -0.049 _IAPYSVEIK(gl)NTCTSVYTK_
PRKDC Ubiquitylation K117 0.540 0.376 _NTCTSVYTK(gl)DR_
PRKDC Ubiquitylation K163 0.679 _FYGELALK(gl)K_
PRKDC Ubiquitylation K164 -0.371 _FYGELALKK(gl)_
PRKDC Ubiquitylation K263 0.272 -0.659 _AIRPQIDLK(gl)R_
PRKDC Ubiquitylation K357 1.479 _NVDSNNK(gl)ELSIAIR_
PRKDC Ubiquitylation K374 -0.342 _GYGLFAGPCK(gl)VINAK_
PRKDC Ubiquitylation K493 -0.582 _ICSK(gl)PVVLPK_
PRKDC Ubiquitylation K689 -0.187 _YFEGVSPK(gl)SLK_
PRKDC Ubiquitylation K810 0.561 0.360 _TSALSDETK(gl)NNWEVSALSR_
PRKDC Ubiquitylation K828 0.723 -0.203 _GFNK(gl)VVLK_
PRKDC Ubiquitylation K832 1.611 -0.278 _VVLK(gl)HLK_
PRKDC Ubiquitylation K838 1.939 1.087 _TK(gl)NLSSNEAISLEEIR_
PRKDC Ubiquitylation K963 -1.201 _ATQMPEGGQGAPPMYQLYK(gl)R_
PRKDC Ubiquitylation K1038 0.646 _EFLK(gl)WSIK_
PRKDC Ubiquitylation K1042 -0.070 -0.432 _WSIK(gl)QITPQQQEK_
PRKDC Ubiquitylation K1051 -1.153 _QITPQQQEK(gl)SPVNTK_
PRKDC Ubiquitylation K1057 -0.693 _SPVNTK(gl)SLFK_
PRKDC Ubiquitylation K1334 0.108 _YNYSK(gl)CTVVVR_
PRKDC Ubiquitylation K1407 -0.971 _ALK(gl)MSPYK_
PRKDC Ubiquitylation K1456 0.657 -0.495 _LAAVVSACK(gl)QLHR_
PRKDC Ubiquitylation K1744 -0.269 _FNNYVDCMK(gl)K_
PRKDC Ubiquitylation K1857 -0.152 _FTK(gl)LNESTFDTQITK_
PRKDC Ubiquitylation K1869 0.803 _LNESTFDTQITK(gl)K_
PRKDC Ubiquitylation K1870 0.843 -0.566 _LNESTFDTQITKK(gl)_
PRKDC Ubiquitylation K1892 -1.132 -1.666 _LPKDDVHAK(gl)ESK_
PRKDC Ubiquitylation K2418 -0.499 _SK(gl)DFVQVMR_
PRKDC Ubiquitylation K2447 -0.500 -1.069 _LK(gl)PVELR_
PRKDC Phosphorylation S2612 -0.226 1.740 _STVLTPMFVETQAS(ph)QGTLQTR_
PRKDC Phosphorylation T2671 -0.097 _SSFDWLTGSSTDPLVDHT(ph)SPSSDSLLFAHK_
PRKDC Phosphorylation S2672 0.083 _SSFDWLTGSSTDPLVDHTS(ph)PSSDSLLFAHK_
PRKDC Phosphorylation S2675 -0.193 _SSFDWLTGSSTDPLVDHTSPSS(ph)DSLLFAHK_
PRKDC Phosphorylation S2677 0.284 -0.009 _SSFDWLTGSSTDPLVDHTSPSSDS(ph)LLFAHK_
PRKDC Ubiquitylation K2694 -1.865 _APLK(gl)SVGPDFGKK_
PRKDC Ubiquitylation K2703 0.600 _SVGPDFGKK(gl)_
PRKDC Ubiquitylation K2715 0.258 -1.356 _LGLPGDEVDNK(gl)VK_
PRKDC Ubiquitylation K2717 -1.795 _LGLPGDEVDNKVK(gl)GAAGR_
PRKDC Ubiquitylation K2738 -0.251 -0.421 _DQEK(gl)LSLMYAR_
PRKDC Ubiquitylation K2758 -0.370 _EKEIK(gl)SELK_
PRKDC Ubiquitylation K2764 0.293 -0.445 _MK(gl)QDAQVVLYR_
PRKDC Ubiquitylation K2829 -1.122 _TLSEK(gl)NNITQK_
PRKDC Ubiquitylation K2908 -0.765 -1.790 _LLPAELPAK(gl)R_
PRKDC Ubiquitylation K2928 0.416 -0.319 _WVELAK(gl)LYR_
PRKDC Ubiquitylation K3158 0.005 -1.352 _QGNLSSQVPLK(gl)R_
PRKDC Ubiquitylation K3192 -0.192 _CFFLSK(gl)IEEK_
PRKDC Phosphorylation S3205 2.096 1.572 _LTPLPEDNS(ph)M(ox)NVDQDGDPSDR_
PRKDC Ubiquitylation K3235 0.810 0.153 _SCK(gl)FSMK_
PRKDC Ubiquitylation K3241 0.107 -0.523 _MK(gl)MIDSAR_
PRKDC Ubiquitylation K3248 0.977 -0.289 _K(gl)QNNFSLAMK_
PRKDC Ubiquitylation K3260 0.018 -1.258 _LLK(gl)ELHK_
PRKDC Ubiquitylation K3455 0.488 -0.615 _ALK(gl)LNSNEAR_
PRKDC Ubiquitylation K3552 1.164 0.277 _NK(gl)EFVAR_
PRKDC Ubiquitylation K3608 1.045 1.399 _NIEK(gl)MYER_
PRKDC Ubiquitylation K3631 -1.002 _K(gl)FIQTFGK_
PRKDC Ubiquitylation K3650 0.475 -0.515 _GGSK(gl)LLR_
PRKDC Ubiquitylation K3710 0.119 -0.965 _GK(gl)PLPEYHVR_
PRKDC Ubiquitylation K3877 0.018 -2.000 _ESK(gl)VPADLLKR_
PRKDC Ubiquitylation K3884 -0.255 -1.203 _VPADLLK(gl)R_
PRKDC Ubiquitylation K4019 -0.937 _NFEQK(gl)MLK_
PRKDC Ubiquitylation K4023 -0.481 _K(gl)GGSWIQEINVAEK_
SFN Ubiquitylation K11 0.561 0.388 _AK(gl)LAEQAER_
SFN Ubiquitylation K49 -0.093 0.337 _NLLSVAYK(gl)_
SIRT1 Phosphorylation S14 -0.369 -0.246 _(ac)ADEAALALQPGGS(ph)PSAAGADR_
SIRT1 Phosphorylation S16 -0.306 -1.665 _(ac)ADEAALALQPGGS(ph)PS(ph)AAGADREAASSPAGEPLR_
SIRT1 Phosphorylation S26 -1.047 -0.245 _EAAS(ph)SPAGEPLR_
SIRT1 Phosphorylation S27 0.351 -0.363 _EAASS(ph)PAGEPLR_
SIRT1 Phosphorylation S47 -0.574 -0.607 _S(ph)PGEPGGAAPER_
SIRT1 Ubiquitylation K238 -1.641 _RK(gl)DINTIEDAVK_
SIRT1 Ubiquitylation K499 -2.138 -0.204 _LGGEYAK(gl)LCCNPVK_
SIRT1 Ubiquitylation K578 -2.782 _GCMEEK(gl)PQEVQTSR_
SIRT1 Ubiquitylation K601 -3.051 _NVESIAEQMENPDLK(gl)NVGSSTGEK_
TBK1 Ubiquitylation K137 -0.689 _DIK(gl)PGNIMR_
TNFRSF1A Ubiquitylation K242 -0.111 _SK(gl)LYSIVCGK_
TOPORS Ubiquitylation K73 -2.412 _ELAASAPARPAPASSEIMASAAK(gl)EFK_
TOPORS Ubiquitylation K76 -2.551 _EFK(gl)MDNFSPK_
TOPORS Ubiquitylation K83 -0.537 -0.928 _MDNFSPK(gl)AGTSK_
TOPORS Phosphorylation S98 -0.529 -0.409 _LQQTVPADAS(ph)PDSK_
TOPORS Ubiquitylation K249 -0.396 0.347 _K(gl)IQEQDIINFRR_
TOPORS Phosphorylation S585 0.204 0.058 _VYS(ph)PYNHR_


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